Discovery of an orally-active nonsteroidal androgen receptor pure antagonist and the structure-activity relationships of its derivatives

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 11, 2008, Pages 1555-1561

  Tachibana, Kazutaka ^a   Imaoka, Ikuhiro ^a   Shiraishi, Takuya ^a   Yoshino, Hitoshi ^a   Nakamura, Mitsuaki ^a   Ohta, Masateru ^a   Kawata, Hiromitsu ^a   Taniguchi, Kenji ^a   Ishikura, Nobuyuki ^a   Tsunenari, Toshiaki ^a   Saito, Hidemi ^a   Nagamuta, Masahiro ^a   Nakagawa, Toshito ^a   Takanashi, Kenji ^a   Onuma, Etsuro ^a   Sato, Haruhiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Androgen receptor; Prostate cancer; Pure antagonist

Indexed keywords

4 [3 (4 CYANO 3 TRIFLUOROMETHYLPHENYL) 5,5 DIMETHYL 4 OXO 2 THIOXOIMIDAZOLIDIN 1 YL]BUTYRIC ACID; ANDROGEN RECEPTOR; ANTIANDROGEN; RU 56187; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANDROGEN ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; GENES, REPORTER; HELA CELLS; HUMANS; INDICATORS AND REAGENTS; MALE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; MODELS, MOLECULAR; RECEPTORS, ANDROGEN; SEMINAL VESICLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOHYDANTOINS;

EID: 55749096019     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.1555     Document Type: Article

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