Discovery and structure-activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 20, 2007, Pages 5573-5576

  Tachibana, Kazutaka ^a   Imaoka, Ikuhiro ^a   Yoshino, Hitoshi ^a   Kato, Nobuaki ^a   Nakamura, Mitsuaki ^a   Ohta, Masateru ^a   Kawata, Hiromitsu ^a   Taniguchi, Kenji ^a   Ishikura, Nobuyuki ^a   Nagamuta, Masahiro ^a   Onuma, Etsuro ^a   Sato, Haruhiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Androgen receptor; Prostate cancer; Pure antagonist

Indexed keywords

ANDROSTANOLONE; ANTIANDROGEN; BICALUTAMIDE; CARBOXYLIC ACID; CH 4892280; HYDROXYFLUTAMIDE; LEAD; METHYLTESTOSTERONE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG BINDING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; REPORTER GENE; STRUCTURE ACTIVITY RELATION;

ANIMALS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, ANDROGEN; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548586872     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.090     Document Type: Article

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