Discovery of 7α-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure-activity relationships

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 1, 2007, Pages 174-185

  Tachibana, Kazutaka ^a   Imaoka, Ikuhiro ^a   Yoshino, Hitoshi ^a   Emura, Takashi ^a   Kodama, Hirohumi ^a   Furuta, Yoshiyuki ^a   Kato, Nobuaki ^a   Nakamura, Mitsuaki ^a   Ohta, Masateru ^a   Taniguchi, Kenji ^a   Ishikura, Nobuyuki ^a   Nagamuta, Masahiro ^a   Onuma, Etsuro ^a   Sato, Haruhiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Androgen receptor; Dihydrotestosterone; Prostate cancer; Pure antagonist

Indexed keywords

AMIDE; ESTER DERIVATIVE; N,N DIMETHYL 8 (17B HYDROXY 5ALPHA ANDROSTAN 3 ONE 7ALPHA YL)OCTANAMIDE; UNCLASSIFIED DRUG; ANDROGEN RECEPTOR; ANDROSTANOLONE; DRUG DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG SYNTHESIS; EVALUATION; IC 50; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; HAMSTER; HELA CELL; HUMAN; STEREOISOMERISM;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; DIHYDROTESTOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, ANDROGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750952292     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.072     Document Type: Article

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