메뉴 건너뛰기




Volumn 97, Issue 10, 2008, Pages 4319-4335

Preparation and characterisation of natamycin: γ-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations

Author keywords

Bioadhesion; Candida spp.; Carbopol 934P; Hydroxypropyl methyl cellulose; Inclusion complex; Natamycin; Vaginal drug delivery; Xanthan gum; cyclodextrin

Indexed keywords

ANTIFUNGAL AGENT; CARBOMER; GAMMA CYCLODEXTRIN; GAMMA CYCLODEXTRIN NATAMYCIN; NATAMYCIN; UNCLASSIFIED DRUG; XANTHAN;

EID: 55749092785     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21312     Document Type: Article
Times cited : (50)

References (61)
  • 1
    • 0037124497 scopus 로고    scopus 로고
    • Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole
    • Cast EK, Valenta C, Leopold M, Bernkop-Schnürch A. 2002. Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole. J Control Release 81:347-354.
    • (2002) J Control Release , vol.81 , pp. 347-354
    • Cast, E.K.1    Valenta, C.2    Leopold, M.3    Bernkop-Schnürch, A.4
  • 2
    • 85031379229 scopus 로고    scopus 로고
    • Safety evaluation of certain food additives and contaminants natamycin (pimaricin)
    • Mattia A, Cerniglia C, Baines J. Safety evaluation of certain food additives and contaminants natamycin (pimaricin), Who Food Additives Series: 48.
    • Who Food Additives Series , vol.48
    • Mattia, A.1    Cerniglia, C.2    Baines, J.3
  • 3
    • 85031373562 scopus 로고    scopus 로고
    • Committee for veterinary medicinal products, natamycin. The European agency for the evaluation of medicinal products veterinary medicines evaluation units. EMEA/MRL/342/98-FINAL, February 1998.
    • Committee for veterinary medicinal products, natamycin. The European agency for the evaluation of medicinal products veterinary medicines evaluation units. EMEA/MRL/342/98-FINAL, February 1998.
  • 4
    • 0038780050 scopus 로고    scopus 로고
    • A case-control teratological study of vaginal natamycin treatment during pregnancy
    • Czeizel AE, Kazy Z, Vargha P. 2003. A case-control teratological study of vaginal natamycin treatment during pregnancy. Reprod Toxicol 17:387-391.
    • (2003) Reprod Toxicol , vol.17 , pp. 387-391
    • Czeizel, A.E.1    Kazy, Z.2    Vargha, P.3
  • 5
    • 46049094302 scopus 로고
    • Some pharmacological properties of pimaricin and possible clinical applications of this antifungal antibiotic
    • Korteweg GC, Szabo KL, Rutten AM, Hoogerheide C. 1963. Some pharmacological properties of pimaricin and possible clinical applications of this antifungal antibiotic. Antibiot Chemother 11:261-272.
    • (1963) Antibiot Chemother , vol.11 , pp. 261-272
    • Korteweg, G.C.1    Szabo, K.L.2    Rutten, A.M.3    Hoogerheide, C.4
  • 7
    • 0242691754 scopus 로고    scopus 로고
    • Formation of Natamycin: Cyclodextrin inclusion complexes and their characterization
    • Koontz JL, Marcy JE. 2003. Formation of Natamycin: Cyclodextrin inclusion complexes and their characterization. J Agric Food Chem 51:7106-7110.
    • (2003) J Agric Food Chem , vol.51 , pp. 7106-7110
    • Koontz, J.L.1    Marcy, J.E.2
  • 8
    • 0029819323 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins, I: Drug solubilization and stabilization
    • Loftsson T, Brewster ME. 1996. Pharmaceutical applications of cyclodextrins, I: Drug solubilization and stabilization. J Pharm Sci 85:1017-1025.
    • (1996) J Pharm Sci , vol.85 , pp. 1017-1025
    • Loftsson, T.1    Brewster, M.E.2
  • 9
    • 0031042310 scopus 로고    scopus 로고
    • Cyclodextrins-enabling excipients: Their present and future use in pharmaceuticals
    • Thompson DO. 1997. Cyclodextrins-enabling excipients: Their present and future use in pharmaceuticals. Crit Rev Ther Drug Carrier Syst 14:1-104.
    • (1997) Crit Rev Ther Drug Carrier Syst , vol.14 , pp. 1-104
    • Thompson, D.O.1
  • 10
    • 84869298534 scopus 로고    scopus 로고
    • Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: Beta-cyclodextrin complex
    • Bilensoy E, Rouf MA, Vural I, Sen M, Hincal AA. 2006. Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: beta-cyclodextrin complex. AAPS Pharm Sci Tech 7:E38.
    • (2006) AAPS Pharm Sci Tech , vol.7
    • Bilensoy, E.1    Rouf, M.A.2    Vural, I.3    Sen, M.4    Hincal, A.A.5
  • 11
    • 0346461917 scopus 로고    scopus 로고
    • Introduction and general overview of cyclodextrin chemistry
    • Szejtli J. 1998. Introduction and general overview of cyclodextrin chemistry. Chem Rev 98:1743-1753.
    • (1998) Chem Rev , vol.98 , pp. 1743-1753
    • Szejtli, J.1
  • 12
    • 1942470488 scopus 로고    scopus 로고
    • Cyclodextrins and their uses: A review
    • Martin Del Valle EM. 2004. Cyclodextrins and their uses: A review. Process Biochem 39:1033-1046.
    • (2004) Process Biochem , vol.39 , pp. 1033-1046
    • Martin Del Valle, E.M.1
  • 14
    • 0021967577 scopus 로고
    • Effect of cyclodextrins on sparingly soluble salts
    • Hirsch W, Fries V, Altman L. 1985. Effect of cyclodextrins on sparingly soluble salts. J Pharm Sci 74:1123-1125.
    • (1985) J Pharm Sci , vol.74 , pp. 1123-1125
    • Hirsch, W.1    Fries, V.2    Altman, L.3
  • 16
    • 0742287066 scopus 로고    scopus 로고
    • Influence of hydroxypropyl-b-cyclodextrin complexation on piroxicam release from bucoadhesive tablets
    • Lug M, Laćan MB. 2004. Influence of hydroxypropyl-b-cyclodextrin complexation on piroxicam release from bucoadhesive tablets. Eur J Pharm Sci 21:251-260.
    • (2004) Eur J Pharm Sci , vol.21 , pp. 251-260
    • Lug, M.1    Laćan, M.B.2
  • 17
    • 0037130164 scopus 로고    scopus 로고
    • Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis
    • Chang JY, Oh YK, Kong HS, Kim EJ, Jang DD, Nam KT, Kim CK. 2002. Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J Control Release 82:39-50.
    • (2002) J Control Release , vol.82 , pp. 39-50
    • Chang, J.Y.1    Oh, Y.K.2    Kong, H.S.3    Kim, E.J.4    Jang, D.D.5    Nam, K.T.6    Kim, C.K.7
  • 18
    • 0034306493 scopus 로고    scopus 로고
    • The scope and potential of vaginal drug delivery
    • Vermani K, Garg S. 2000. The scope and potential of vaginal drug delivery. Pharm Sci Technol Today 3:359-364.
    • (2000) Pharm Sci Technol Today , vol.3 , pp. 359-364
    • Vermani, K.1    Garg, S.2
  • 19
    • 0026671198 scopus 로고
    • Principle and investigations of the bioadhesion mechanism of solid dosage forms
    • Duchene D, Ponchel G. 1992. Principle and investigations of the bioadhesion mechanism of solid dosage forms. Biomaterials 13:709-714.
    • (1992) Biomaterials , vol.13 , pp. 709-714
    • Duchene, D.1    Ponchel, G.2
  • 20
    • 22044457597 scopus 로고    scopus 로고
    • Mucoadhesive microspheres for controlled drug delivery
    • Chowdary KPR, Rao YS. 2004. Mucoadhesive microspheres for controlled drug delivery. Biol Pharm Bull 27:1717-1734.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1717-1734
    • Chowdary, K.P.R.1    Rao, Y.S.2
  • 21
    • 26844560127 scopus 로고    scopus 로고
    • The use of mucoadhesive polymers in vaginal drug delivery
    • Valenta C. 2005. The use of mucoadhesive polymers in vaginal drug delivery. Adv Drug Del Rev 57:1692-1712.
    • (2005) Adv Drug Del Rev , vol.57 , pp. 1692-1712
    • Valenta, C.1
  • 22
    • 0027670707 scopus 로고
    • Drug delivery using buccal-adhesive systems
    • Smart JD. 1993. Drug delivery using buccal-adhesive systems. Adv Drug Del Rev 11:253-270.
    • (1993) Adv Drug Del Rev , vol.11 , pp. 253-270
    • Smart, J.D.1
  • 23
    • 1842557581 scopus 로고    scopus 로고
    • Matrix tablets based on thiolated poly(acrylic acid): PH-dependent variation in disintegration and mucoadhesion
    • Guggi D, Marschütz MK, Bernkop-Schnürch A. 2004. Matrix tablets based on thiolated poly(acrylic acid): pH-dependent variation in disintegration and mucoadhesion. Int J Pharm 274:97-105.
    • (2004) Int J Pharm , vol.274 , pp. 97-105
    • Guggi, D.1    Marschütz, M.K.2    Bernkop-Schnürch, A.3
  • 25
    • 0742287066 scopus 로고    scopus 로고
    • Influence of hydroxypropyl-bcyclodextrin complaxation piroxicam release from buccoadhesive tablets
    • Jug M, Bećirević-Laćan M. 2004. Influence of hydroxypropyl-bcyclodextrin complaxation piroxicam release from buccoadhesive tablets. Eur J Pharm Sci 21:251-260.
    • (2004) Eur J Pharm Sci , vol.21 , pp. 251-260
    • Jug, M.1    Bećirević-Laćan, M.2
  • 27
    • 0242439413 scopus 로고    scopus 로고
    • Stability of Natamycin and its cyclodextrin inclusion complexes in aqueous solution
    • Koontz JL, Marcy JE, Barbeau WE, Duncan SE. 2003. Stability of Natamycin and its cyclodextrin inclusion complexes in aqueous solution. J Agric Food Chem 51:7111-7114.
    • (2003) J Agric Food Chem , vol.51 , pp. 7111-7114
    • Koontz, J.L.1    Marcy, J.E.2    Barbeau, W.E.3    Duncan, S.E.4
  • 28
    • 0343359244 scopus 로고
    • Investigation of exchange processes by two-dimensional NMR spectroscopy
    • Jeener J, Meier BH, Ernst BP, Ernst RR. 1979. Investigation of exchange processes by two-dimensional NMR spectroscopy. J Chem Phys 71:4546-4553.
    • (1979) J Chem Phys , vol.71 , pp. 4546-4553
    • Jeener, J.1    Meier, B.H.2    Ernst, B.P.3    Ernst, R.R.4
  • 30
    • 0002522655 scopus 로고
    • Continuum solution model: Classical and quantum mechanical implementations
    • Lipkowitz KB, Boyd DB, editors, New York: VCH
    • Cramer CJ, Truhlar DG. Continuum solution model: classical and quantum mechanical implementations. In: Lipkowitz KB, Boyd DB, editors. Reviews in computational chemistry. Vol. 6. New York: VCH. 1995. pp. 1-72.
    • (1995) Reviews in computational chemistry , vol.6 , pp. 1-72
    • Cramer, C.J.1    Truhlar, D.G.2
  • 31
    • 0344778061 scopus 로고
    • Semianalytical treatment of solvation for molecular mechanics and dynamics
    • Still WC, Tempczyk A, Hawley RC, Hendrickson T. 1990. Semianalytical treatment of solvation for molecular mechanics and dynamics. J Am Chem Soc 112:6127-6129.
    • (1990) J Am Chem Soc , vol.112 , pp. 6127-6129
    • Still, W.C.1    Tempczyk, A.2    Hawley, R.C.3    Hendrickson, T.4
  • 32
    • 84986532529 scopus 로고
    • Cluster analysis of molecular conformations
    • Shenkin PS, McDonald DQ. 1994. Cluster analysis of molecular conformations. J Comput Chem 15:899-916.
    • (1994) J Comput Chem , vol.15 , pp. 899-916
    • Shenkin, P.S.1    McDonald, D.Q.2
  • 33
    • 85031373176 scopus 로고    scopus 로고
    • Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved Standard
    • National Committee for Clinical Laboratory Standards, National Committee for Clinical Laboratory Standards, Wayne, PA
    • National Committee for Clinical Laboratory Standards. 1997. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved Standard. Document M27-A. National Committee for Clinical Laboratory Standards, Wayne, PA.
    • (1997) Document M27-A
  • 34
    • 85031389639 scopus 로고    scopus 로고
    • USP28/NF23. 2005. United States Pharmacopeia 28/National Formulary. 23. Pharmaceutical Convention Inc. Rockwell, MD, USA.
    • USP28/NF23. 2005. United States Pharmacopeia 28/National Formulary. 23. Pharmaceutical Convention Inc. Rockwell, MD, USA.
  • 35
    • 0020617063 scopus 로고
    • Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: Effect of entrapped air
    • Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. 1983. Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: Effect of entrapped air. J Pharm Sci 72:1189-1191.
    • (1983) J Pharm Sci , vol.72 , pp. 1189-1191
    • Korsmeyer, R.W.1    Gurny, R.2    Doelker, E.3    Buri, P.4    Peppas, N.A.5
  • 36
    • 0021904208 scopus 로고
    • Analysis of Fickian and non-Fickian drug release from polymers
    • Peppas NA. 1985. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv 60:110-111.
    • (1985) Pharm Acta Helv , vol.60 , pp. 110-111
    • Peppas, N.A.1
  • 37
    • 0023196815 scopus 로고
    • A simple equation for descriction of solute release. II Fickian and anomalous release from swellable devices
    • Ritger PL, Peppas NA. 1987. A simple equation for descriction of solute release. II Fickian and anomalous release from swellable devices. J Control Release 5:37-42.
    • (1987) J Control Release , vol.5 , pp. 37-42
    • Ritger, P.L.1    Peppas, N.A.2
  • 38
    • 0032581790 scopus 로고    scopus 로고
    • Effect of cyclodextrins on the physicochemical properties and antimycotic properties of clotrimazole
    • Ahmed MO, El-Gibaly I, Ahmed SM. 1998. Effect of cyclodextrins on the physicochemical properties and antimycotic properties of clotrimazole. Int J Pharm 171:111-121.
    • (1998) Int J Pharm , vol.171 , pp. 111-121
    • Ahmed, M.O.1    El-Gibaly, I.2    Ahmed, S.M.3
  • 41
    • 0842330581 scopus 로고    scopus 로고
    • Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis
    • Pralhad T, Rajendrakumar K. 2004. Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis. J Pharm Biomed Anal 34:333-339.
    • (2004) J Pharm Biomed Anal , vol.34 , pp. 333-339
    • Pralhad, T.1    Rajendrakumar, K.2
  • 42
    • 0347651904 scopus 로고    scopus 로고
    • The physicochemical characteristics and bioavailability of indomethacin from beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, and hydroxypropyl-beta-cyclodextrin complexes
    • Jambhekar S, Casella R, Maher T. 2004. The physicochemical characteristics and bioavailability of indomethacin from beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, and hydroxypropyl-beta-cyclodextrin complexes. Int J Pharm 270:149-166.
    • (2004) Int J Pharm , vol.270 , pp. 149-166
    • Jambhekar, S.1    Casella, R.2    Maher, T.3
  • 43
    • 34248661543 scopus 로고    scopus 로고
    • Beta-cyclodextrin complexes of celecoxib: Molecular-modeling, characterization, and dissolution studies
    • Reddy MN, Rehana T, Ramakrishna S, Chowdhary KPR, Diwan PV. 2004. Beta-cyclodextrin complexes of celecoxib: Molecular-modeling, characterization, and dissolution studies. AAPS Pharm Sci Tech 5-6:E7.
    • (2004) AAPS Pharm Sci Tech , vol.5-6
    • Reddy, M.N.1    Rehana, T.2    Ramakrishna, S.3    Chowdhary, K.P.R.4    Diwan, P.V.5
  • 45
    • 0017080115 scopus 로고
    • New high-molecular decomposition products of natamycin (pimaricin) with intact lactone-ring
    • Brik H. 1976. New high-molecular decomposition products of natamycin (pimaricin) with intact lactone-ring. J Antibiot 29:632-637.
    • (1976) J Antibiot , vol.29 , pp. 632-637
    • Brik, H.1
  • 46
    • 33846454390 scopus 로고    scopus 로고
    • Efficacy of intravenous itraconazole against invasive pulmonary aspergillosis in neutropenic mice
    • Tansho S, Abe S, Ishibashi H, Torii S, Otani H, Ono Y, Yamaguchi H. 2006. Efficacy of intravenous itraconazole against invasive pulmonary aspergillosis in neutropenic mice. J Infect Chemother 12:355-362.
    • (2006) J Infect Chemother , vol.12 , pp. 355-362
    • Tansho, S.1    Abe, S.2    Ishibashi, H.3    Torii, S.4    Otani, H.5    Ono, Y.6    Yamaguchi, H.7
  • 47
    • 33751247035 scopus 로고    scopus 로고
    • Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins
    • Hamada H, Ishihara K, Masuoka N, Mikuni K, Nakajima N. 2006. Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins. J Biosci Bioeng 102:369-371.
    • (2006) J Biosci Bioeng , vol.102 , pp. 369-371
    • Hamada, H.1    Ishihara, K.2    Masuoka, N.3    Mikuni, K.4    Nakajima, N.5
  • 48
    • 0032509831 scopus 로고    scopus 로고
    • Evaluation of possible mechanism(s) of bioadhesion
    • Tur KM, Ching HS. 1998. Evaluation of possible mechanism(s) of bioadhesion. Int J Pharm 160:61-74.
    • (1998) Int J Pharm , vol.160 , pp. 61-74
    • Tur, K.M.1    Ching, H.S.2
  • 49
    • 0029153321 scopus 로고
    • In-vitro studies on bucoadhesive tablet formulations of hydrocortisone hemisuccinate
    • Fabregas JL, Garcia N. 1995. In-vitro studies on bucoadhesive tablet formulations of hydrocortisone hemisuccinate. Drug Dev Ind Pharm 21:1689-1696.
    • (1995) Drug Dev Ind Pharm , vol.21 , pp. 1689-1696
    • Fabregas, J.L.1    Garcia, N.2
  • 50
    • 0022402037 scopus 로고
    • Surface interfacial and molecular aspects of polymer bioadhesion on soft tissues
    • Peppas NA, Bury PA. 1985. Surface interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 2:257-275.
    • (1985) J Control Release , vol.2 , pp. 257-275
    • Peppas, N.A.1    Bury, P.A.2
  • 51
    • 0344519699 scopus 로고    scopus 로고
    • An in vitro investigation for vaginal bioadhesive formulations: Bioadhesive properties and swelling states of polymer mixtures
    • Baloglu E, Ozyazici M, Hizarcioglu SY, Karavana HA. 2003. An in vitro investigation for vaginal bioadhesive formulations: Bioadhesive properties and swelling states of polymer mixtures. Farmaco 58:391-396.
    • (2003) Farmaco , vol.58 , pp. 391-396
    • Baloglu, E.1    Ozyazici, M.2    Hizarcioglu, S.Y.3    Karavana, H.A.4
  • 52
    • 7544224447 scopus 로고    scopus 로고
    • Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation
    • Nafee NA, Ismail FA, Boraie NA, Mortada LM. 2004. Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation. Drug Dev Ind Pharm 30:985-993.
    • (2004) Drug Dev Ind Pharm , vol.30 , pp. 985-993
    • Nafee, N.A.1    Ismail, F.A.2    Boraie, N.A.3    Mortada, L.M.4
  • 53
    • 33748853479 scopus 로고    scopus 로고
    • Once daily bioadhesive vaginal clotrimazole tablet: Design and evaluation
    • Sharma G, Jain S, Tiwary AK, Kaur G. 2006. Once daily bioadhesive vaginal clotrimazole tablet: Design and evaluation. Acta Pharm 56:337-345.
    • (2006) Acta Pharm , vol.56 , pp. 337-345
    • Sharma, G.1    Jain, S.2    Tiwary, A.K.3    Kaur, G.4
  • 54
    • 85011783871 scopus 로고    scopus 로고
    • Noveon Pharmaceutical Bulletin 16:, Noveon Inc, Cleveland, Ohio
    • Noveon Pharmaceutical Bulletin 16: Bioadhesion, Noveon Inc., Cleveland, Ohio.
    • Bioadhesion
  • 55
    • 55749104964 scopus 로고
    • Factors influencing gel strengthening at the mucoadhesive-mucus interface
    • Mortazavi SA, Smart JD. 1994. Factors influencing gel strengthening at the mucoadhesive-mucus interface. J Pharm Pharmacol 48:285-287.
    • (1994) J Pharm Pharmacol , vol.48 , pp. 285-287
    • Mortazavi, S.A.1    Smart, J.D.2
  • 56
    • 0024352077 scopus 로고
    • A novel in situ method to test polymers and coated microparticles for bioadhesion
    • Ranga Rao KV, Buri P. 1989. A novel in situ method to test polymers and coated microparticles for bioadhesion. Int J Pharm 52:265-270.
    • (1989) Int J Pharm , vol.52 , pp. 265-270
    • Ranga Rao, K.V.1    Buri, P.2
  • 57
    • 38149103499 scopus 로고    scopus 로고
    • Evaluation of mechanical and mucoadhesive properties of clomiphene citrate gel formulations containing carbomers and their thiolated derivatives
    • Cevher E, Taha MAM, Orlu M, Araman A. 2008. Evaluation of mechanical and mucoadhesive properties of clomiphene citrate gel formulations containing carbomers and their thiolated derivatives. Drug Deliv 15:57-67.
    • (2008) Drug Deliv , vol.15 , pp. 57-67
    • Cevher, E.1    Taha, M.A.M.2    Orlu, M.3    Araman, A.4
  • 59
    • 33750863935 scopus 로고    scopus 로고
    • Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets
    • Khamanga SM, Walker RB. 2006. Evaluation of rate of swelling and erosion of verapamil (VRP) sustained-release matrix tablets. Drug Dev Ind Pharm 32:1139-1148.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 1139-1148
    • Khamanga, S.M.1    Walker, R.B.2
  • 60
    • 0027436487 scopus 로고
    • Multiple layer, direct compresiion controlled release systems: In vitro and in vivo evaluation
    • Fassihi RA, Ritschel WA. 1993. Multiple layer, direct compresiion controlled release systems: In vitro and in vivo evaluation. J Pharm Sci 82:750-754.
    • (1993) J Pharm Sci , vol.82 , pp. 750-754
    • Fassihi, R.A.1    Ritschel, W.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.