Effect of peroxisome proliferator-activated receptor-gamma on airway smooth muscle thickening in a murine model of chronic asthma

International Archives of Allergy and Immunology

Volumn 148, Issue 4, 2009, Pages 289-296

  Rhee, Chin Kook ^a   Lee, Sook Young ^a   Kang, Ji Young ^a   Kim, Seung Joon ^a   Kwon, Soon Suk ^a   Kim, Young Kyoon ^a   Park, Sung Hak ^a,b  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Asthma; Peroxisome proliferator activated receptor ; Smooth muscle; Transforming growth factor 1; Vascular endothelial growth factor

Indexed keywords

CIGLITAZONE; CYTOKINE; METHACHOLINE; OVALBUMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL; FEMALE; INFLAMMATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; SMOOTH MUSCLE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHI; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH; OVALBUMIN; PPAR GAMMA; RESPIRATORY HYPERSENSITIVITY; THIAZOLIDINEDIONES; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 55549145446     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000170382     Document Type: Article

References (48)

1. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC: A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992;145:1251-1258.
2. Lazaar AL, Panettieri RA Jr: Biology of airway smooth muscle cells; in Adkinson NF Jr, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simons FER (eds): Middleton's Allergy Principles and Practice. Philadelphia, Mosby, 2003, p 399.
3. Ebina M, Takahashi T, Chiba T, Motomiya M: Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 1993;148:720-726.
4. James AL, Pare PD, Hogg JC: The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989;139:242-246.
5. Elias JA, Zhu Z, Chupp G, Homer RJ: Airway remodeling in asthma. J Clin Invest 1999;104:1001-1006.
6. Hoshino M, Nakamura Y, Sim JJ: Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 1998;53:21-27.
7. Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999;20:649-688.
8. Tontonoz P, Hu E, Spiegelman BM: Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994;79:1147-1156.
9. Serhan CN: Inflammation. Signalling the fat controller. Nature 1996;384:23-24.
10. Gelman L, Fruchart JC, Auwerx J: An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer. Cell Mol Life Sci 1999;55:932-943.
11. Benayoun L, Letuve S, Druilhe A, Boczkowski J, Dombret MC, Mechighel P, Megret J, Leseche G, Aubier M, Pretolani M: Regulation of peroxisome proliferator-activated receptor gamma expression in human asthmatic airways: relationship with proliferation, apoptosis, and airway remodeling. Am J Respir Crit Care Med 2001;164:1487-1494.
12. Solway J, Irvin CG: Airway smooth muscle as a target for asthma therapy. N Engl J Med 2007;356:1367-1369.
13. Panettieri RA Jr: Airway smooth muscle: immunomodulatory cells? Allergy Asthma Proc 2004;25:381-386.
14. Usmani OS, Ito K, Maneechotesuwan K, Ito M, Johnson M, Barnes PJ, Adcock IM: Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med 2005;172:704-712.
15. Stewart AG, Fernandes D, Tomlinson PR: The effect of glucocorticoids on proliferation of human cultured airway smooth muscle. Br J Pharmacol 1995;116:3219-3226.
16. Chen YE, Fu M, Zhang J, Zhu X, Lin Y, Akinbami MA, Song Q: Peroxisome proliferator-activated receptors and the cardiovascular system. Vitam Horm 2003;66:157-188.
17. Zingarelli B, Cook JA: Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and inflammation. Shock 2005;23:393-399.
18. Hinz B, Brune K, Pahl A: 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPARgamma-independent mechanism. Biochem Biophys Res Commun 2003;302:415-420.
19. Wang AC, Dai X, Luu B, Conrad DJ: Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. Am J Respir Cell Mol Biol 2001;24:688-693.
20. Pang L, Nie M, Corbett L, Knox AJ: Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. J Immunol 2003;170:1043-1051.
21. Nie M, Corbett L, Knox AJ, Pang L: Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. J Biol Chem 2005;280:2550-2561.
22. Patel HJ, Belvisi MG, Bishop-Bailey D, Yacoub MH, Mitchell JA: Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J Immunol 2003;170:2663-2669.
23. Ueki S, Kato H, Kobayashi Y, Ito W, Adachi T, Nagase H, Ohta K, Kayaba H, Chihara J: Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2 (15d-PGJ2) on human eosinophil functions. Int Arch Allergy Immunol 2007;143:15-22.
24. Woerly G, Honda K, Loyens M, Papin JP, Auwerx J, Staels B, Capron M, Dombrowicz D: Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J Exp Med 2003;198:411-421.
25. Mueller C, Weaver V, Vanden Heuvel JP, August A, Cantorna MT: Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys 2003;418:186-196.
26. Hammad H, de Heer HJ, Soullié T, Angeli V, Trottein F, Hoogsteden HC, Lambrecht BN: Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma. Am J Pathol 2004;164:263-271.
27. Honda K, Marquillies P, Capron M, Dombrowicz D: Peroxisome proliferator-activated receptor gamma is expressed in airways and inhibits features of airway remodeling in a mouse asthma model. J Allergy Clin Immunol 2004;113:882-888.
28. Johnson PR, Roth M, Tamm M, Hughes M, Ge Q, King G, Burgess JK, Black JL: Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 2001;164:474-477.
29. Burgess JK, Johnson PR, Ge Q, Au WW, Poniris MH, McParland BE, King G, Roth M, Black JL: Expression of connective tissue growth factor in asthmatic airway smooth muscle cells. Am J Respir Crit Care Med 2003;167:71-77.
30. Nagai A, Inano H, Takizawa T: Morphologic changes in the airways induced by recurrent exposure of acetylcholine in the guinea pig. Am Rev Respir Dis 1990;142:172-176.
31. Panettieri RA Jr: Cellular and molecular mechanisms regulating airway smooth muscle proliferation and cell adhesion molecule expression. Am J Respir Crit Care Med 1998;158:S133-S140.
32. Zhou L, Li J, Goldsmith AM, Newcomb DC, Giannola DM, Vosk RG, Eves EM, Rosner MR, Solway J, Hershenson MB: Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma. Am J Respir Crit Care Med 2004;169:703-711.
33. Yang B, Lin P, Carrick KM, McNulty JA, Clifton LG, Winegar DA, Strum JC, Stimpson SA, Pahel GL: PPARgamma agonists diminish serum VEGF elevation in diet-induced insulin resistant SD rats and ZDF rats. Biochem Biophys Res Commun 2005;334:176-182.
34. Lee SY, Kim JS, Lee JM, Kwon SS, Kim KH, Moon HS, Song JS, Park SH, Kim YK: Inhaled corticosteroid prevents the thickening of airway smooth muscle in murine model of chronic asthma. Pulm Pharmacol Ther 2006;21:14-19.
35. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-1745.
36. Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL: Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000;105:193-204.
37. Law RE, Meehan WP, Xi XP, Graf K, Wuthrich DA, Coats W, Faxon D, Hsueh WA: Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia. J Clin Invest 1996;98:1897-1905.
38. Bishop-Bailey D, Hla T: Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-12,14- prostaglandin J2. J Biol Chem 1999;274:17042-17048.
39. Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ: The nuclear receptor PPAR and immunoregulation: PPAR mediates inhibition of helper T cell responses. J Immunol 2000;164:1364-1371.
40. Harris SG, Phipps RP: The nuclear receptor PPAR is expressed by mouse T lymphocytes and PPAR agonists induce apoptosis. Eur J Immunol 2001;31:1098-1105.
41. Chinetti G, Griglio S, Antonucci M, Torra IP, Delerive P, Majd Z, Fruchart JC, Chapman J, Najib J, Staels B: Activation of proliferator-activated receptors and induces apoptosis of human monocyte-derived macrophages. J Biol Chem 1998;273:25573-25580.
42. Ward JE, Gould H, Harris T, Bonacci JV, Stewart AG: PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. Br J Pharmacol 2004;141:517-525.
43. Hocevar BA, Brown TL, Howe PH: TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 1999;18:1345-1356.
44. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 1995;270:2008-2011.
45. Delerive P, Fruchart JC, Staels B: Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001;169:453-459.
46. Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, Auwerx J: Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med 2001;193:827-838.
47. Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X, Chen YE: Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem 2001;276:45888-45894.
48. Sander TL, Noll L, Klinkner DB, Weihrauch D, He BJ, Kaul S, Zangwill SD, Tweddell JS, Pritchard KA Jr, Oldham KT: Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. Endothelium 2006;13:181-190.