메뉴 건너뛰기




Volumn 36, Issue 12, 2008, Pages 1616-1624

Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLPHOSPHATIDYLINOSITOL; LACTATE DEHYDROGENASE; PLASMIN; UROKINASE; UROKINASE RECEPTOR;

EID: 55549137683     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.06.016     Document Type: Article
Times cited : (49)

References (38)
  • 1
    • 26844504636 scopus 로고    scopus 로고
    • Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment
    • Young N.S. Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment. Curr Hematol Rep 4 (2005) 103-109
    • (2005) Curr Hematol Rep , vol.4 , pp. 103-109
    • Young, N.S.1
  • 2
    • 28444483571 scopus 로고    scopus 로고
    • Diagnosis and management of paroxysmal nocturnal hemoglobinuria
    • Parker C., Omine M., Richards S., et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 106 (2005) 3699-3709
    • (2005) Blood , vol.106 , pp. 3699-3709
    • Parker, C.1    Omine, M.2    Richards, S.3
  • 3
    • 33646527709 scopus 로고    scopus 로고
    • The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)
    • Araten D.J., and Luzzatto L. The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood 108 (2006) 734-736
    • (2006) Blood , vol.108 , pp. 734-736
    • Araten, D.J.1    Luzzatto, L.2
  • 4
    • 2442532784 scopus 로고    scopus 로고
    • Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan
    • Nishimura J., Kanakura Y., Ware R.E., et al. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) 83 (2004) 193-207
    • (2004) Medicine (Baltimore) , vol.83 , pp. 193-207
    • Nishimura, J.1    Kanakura, Y.2    Ware, R.E.3
  • 5
    • 0036236122 scopus 로고    scopus 로고
    • Transfer of prostasomal CD59 to CD59-deficient red blood cells results in protection against complement-mediated hemolysis
    • Babiker A.A., Ronquist G., Nilsson U.R., and Nilsson B. Transfer of prostasomal CD59 to CD59-deficient red blood cells results in protection against complement-mediated hemolysis. Am J Reprod Immunol 47 (2002) 183-192
    • (2002) Am J Reprod Immunol , vol.47 , pp. 183-192
    • Babiker, A.A.1    Ronquist, G.2    Nilsson, U.R.3    Nilsson, B.4
  • 6
    • 0026474486 scopus 로고
    • Relative roles of decay-accelerating factor membrane cofactor protein and CD59 in the protection of human endothelial cells against complement-mediated lysis
    • Brooimans R.A., van Wieringen P.A.M., Van Es L.A., and Daha M.R. Relative roles of decay-accelerating factor membrane cofactor protein and CD59 in the protection of human endothelial cells against complement-mediated lysis. Eur J Immunol 22 (1992) 3135-3140
    • (1992) Eur J Immunol , vol.22 , pp. 3135-3140
    • Brooimans, R.A.1    van Wieringen, P.A.M.2    Van Es, L.A.3    Daha, M.R.4
  • 7
    • 0025179976 scopus 로고
    • Human protectin (CD59), an 18,000-2000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers
    • Meri S., Morgan B.P., Davies A., Daniels R.H., Olavesen M.G., Waldmann H., and Lachmann P.J. Human protectin (CD59), an 18,000-2000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology 71 (1990) 1-9
    • (1990) Immunology , vol.71 , pp. 1-9
    • Meri, S.1    Morgan, B.P.2    Davies, A.3    Daniels, R.H.4    Olavesen, M.G.5    Waldmann, H.6    Lachmann, P.J.7
  • 8
    • 0008840960 scopus 로고    scopus 로고
    • Thrombotic Complications in PNH
    • Young N.S., and Moss J. (Eds), Academic Press, San Diego, CA
    • Sloand E.M., and Young N.S. Thrombotic Complications in PNH. In: Young N.S., and Moss J. (Eds). PNH and the GPI-Linked Proteins (2000), Academic Press, San Diego, CA 101-112
    • (2000) PNH and the GPI-Linked Proteins , pp. 101-112
    • Sloand, E.M.1    Young, N.S.2
  • 9
    • 0015789610 scopus 로고
    • Activation of the alternate complement pathway by autologous red cel stroma
    • Poskitt T.R., Fortwengler Jr. H.P., and Lunskis B.J. Activation of the alternate complement pathway by autologous red cel stroma. J Exp Med 138 (1973) 715-722
    • (1973) J Exp Med , vol.138 , pp. 715-722
    • Poskitt, T.R.1    Fortwengler Jr., H.P.2    Lunskis, B.J.3
  • 10
    • 3042693914 scopus 로고    scopus 로고
    • Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria
    • Simak J., Holada K., Risitano A.M., Zivny J.H., Young N.S., and Vstal J.G. Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria. Br J Haematol 125 (2004) 804-813
    • (2004) Br J Haematol , vol.125 , pp. 804-813
    • Simak, J.1    Holada, K.2    Risitano, A.M.3    Zivny, J.H.4    Young, N.S.5    Vstal, J.G.6
  • 11
    • 0033562372 scopus 로고    scopus 로고
    • Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia
    • Hugel B., Socie G., Vu T., et al. Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia. Blood 93 (1999) 3451-3456
    • (1999) Blood , vol.93 , pp. 3451-3456
    • Hugel, B.1    Socie, G.2    Vu, T.3
  • 12
    • 18244426909 scopus 로고    scopus 로고
    • Plasmatic coagulation and fibrinolytic system alterations in PNH: relation to clone size
    • Grunewald M., Siegemund A., Grunewald A., et al. Plasmatic coagulation and fibrinolytic system alterations in PNH: relation to clone size. Blood Coagul Fibrinolysis 14 (2003) 685-695
    • (2003) Blood Coagul Fibrinolysis , vol.14 , pp. 685-695
    • Grunewald, M.1    Siegemund, A.2    Grunewald, A.3
  • 13
    • 0030782196 scopus 로고    scopus 로고
    • Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR
    • Plesner T., Behrendt N., and Ploug M. Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR. Stem Cells 15 (1997) 398-408
    • (1997) Stem Cells , vol.15 , pp. 398-408
    • Plesner, T.1    Behrendt, N.2    Ploug, M.3
  • 14
    • 0026674918 scopus 로고
    • A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria
    • Ploug M., Eriksen J., Plesner T., Hansen N.E., and Dano K. A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria. Eur J Biochem 208 (1992) 397-404
    • (1992) Eur J Biochem , vol.208 , pp. 397-404
    • Ploug, M.1    Eriksen, J.2    Plesner, T.3    Hansen, N.E.4    Dano, K.5
  • 15
    • 0028031885 scopus 로고
    • The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils
    • Plesner T., Ploug M., Ellis V., et al. The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils. Blood 83 (1994) 808-815
    • (1994) Blood , vol.83 , pp. 808-815
    • Plesner, T.1    Ploug, M.2    Ellis, V.3
  • 16
    • 0027394284 scopus 로고
    • Structure and function of the urokinase receptor. Blood Coagul
    • Moller L.B. Structure and function of the urokinase receptor. Blood Coagul. Fibrinolysis 4 (1993) 293-303
    • (1993) Fibrinolysis , vol.4 , pp. 293-303
    • Moller, L.B.1
  • 17
    • 0028953704 scopus 로고
    • The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuria
    • Ronne E., Pappot H., Grondahl-Hansen J., et al. The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol 89 (1995) 576-581
    • (1995) Br J Haematol , vol.89 , pp. 576-581
    • Ronne, E.1    Pappot, H.2    Grondahl-Hansen, J.3
  • 18
    • 0031127996 scopus 로고    scopus 로고
    • Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity
    • Ninomiya H., Hasegawa Y., Nagasawa T., and Abe T. Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity. Int J Hematol 65 (1997) 285-291
    • (1997) Int J Hematol , vol.65 , pp. 285-291
    • Ninomiya, H.1    Hasegawa, Y.2    Nagasawa, T.3    Abe, T.4
  • 19
    • 0344875558 scopus 로고    scopus 로고
    • Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling
    • Jo M., Thomas K.S., Wu L., and Gonias S.L. Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling. J Biol Chem 278 (2003) 46692-46698
    • (2003) J Biol Chem , vol.278 , pp. 46692-46698
    • Jo, M.1    Thomas, K.S.2    Wu, L.3    Gonias, S.L.4
  • 20
    • 0029952542 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator
    • Bugge T.H., Flick M.J., Danton M.J., et al. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc Natl Acad Sci U S A 93 (1996) 5899-5904
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5899-5904
    • Bugge, T.H.1    Flick, M.J.2    Danton, M.J.3
  • 21
    • 0032530889 scopus 로고    scopus 로고
    • Lysis of plasma clots by urokinase-soluble urokinase receptor complexes
    • Higazi A.A., Bdeir K., Hiss E., et al. Lysis of plasma clots by urokinase-soluble urokinase receptor complexes. Blood 92 (1998) 2075-2083
    • (1998) Blood , vol.92 , pp. 2075-2083
    • Higazi, A.A.1    Bdeir, K.2    Hiss, E.3
  • 22
    • 0346433810 scopus 로고    scopus 로고
    • Thrombosis in patients with paroxysmal noctural hemoglobinuria is associated with markedly elevated plasma levels of leukocyte-derived tissue factor
    • Liebman H.A., and Feinstein D.I. Thrombosis in patients with paroxysmal noctural hemoglobinuria is associated with markedly elevated plasma levels of leukocyte-derived tissue factor. Thromb Res. 111 (2003) 235-238
    • (2003) Thromb Res. , vol.111 , pp. 235-238
    • Liebman, H.A.1    Feinstein, D.I.2
  • 23
    • 0029886219 scopus 로고    scopus 로고
    • Functional analysis of the cellular receptor for urokinase in plasminogen activation. Receptor binding has no influence on the zymogenic nature of pro-urokinase
    • Ellis V. Functional analysis of the cellular receptor for urokinase in plasminogen activation. Receptor binding has no influence on the zymogenic nature of pro-urokinase. J Biol Chem 271 (1996) 14779-14784
    • (1996) J Biol Chem , vol.271 , pp. 14779-14784
    • Ellis, V.1
  • 24
    • 0024508318 scopus 로고    scopus 로고
    • Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes
    • Ellis V., Scully M.F., and Kakkar V.V. Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. J Biol Chem 264 (1999) 2185-2188
    • (1999) J Biol Chem , vol.264 , pp. 2185-2188
    • Ellis, V.1    Scully, M.F.2    Kakkar, V.V.3
  • 25
    • 0035673563 scopus 로고    scopus 로고
    • Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones
    • Maciejewski J.P., Rivera C., Kook H., Dunn D., and Young N.S. Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones. Br J Haematol 115 (2001) 1015-1022
    • (2001) Br J Haematol , vol.115 , pp. 1015-1022
    • Maciejewski, J.P.1    Rivera, C.2    Kook, H.3    Dunn, D.4    Young, N.S.5
  • 26
    • 20144382507 scopus 로고    scopus 로고
    • Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization
    • Selleri C., Montuori N., Ricci P., et al. Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood 105 (2005) 2198-2205
    • (2005) Blood , vol.105 , pp. 2198-2205
    • Selleri, C.1    Montuori, N.2    Ricci, P.3
  • 27
    • 0034661197 scopus 로고    scopus 로고
    • Comparison of the effect of histidine-rich glycoprotein and 6-aminohexanoic acid on plasmin production and fibrinolysis in vitro
    • Horne III M.K., Goad J.L., Merryman P.K., and Cullinane A.M. Comparison of the effect of histidine-rich glycoprotein and 6-aminohexanoic acid on plasmin production and fibrinolysis in vitro. Thromb Res 99 (2000) 179-186
    • (2000) Thromb Res , vol.99 , pp. 179-186
    • Horne III, M.K.1    Goad, J.L.2    Merryman, P.K.3    Cullinane, A.M.4
  • 28
    • 0030859776 scopus 로고    scopus 로고
    • Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients
    • Sloand E.M., Young N.S., Sato T., Kumar P., Kim S., Weichold F.F., and Maciejewski J.P. Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients. AIDS 11 (1997) 1547-1553
    • (1997) AIDS , vol.11 , pp. 1547-1553
    • Sloand, E.M.1    Young, N.S.2    Sato, T.3    Kumar, P.4    Kim, S.5    Weichold, F.F.6    Maciejewski, J.P.7
  • 29
    • 0031596167 scopus 로고    scopus 로고
    • Inhibition of interleukin-1β-converting enzyme in human hematopoietic progenitor cells results in blockade of cytokine-mediated apoptosis and expansion of their proliferative potential
    • Sloand E., Young N.S., Sato T., Kim S., and Maciejewski J.P. Inhibition of interleukin-1β-converting enzyme in human hematopoietic progenitor cells results in blockade of cytokine-mediated apoptosis and expansion of their proliferative potential. Exp Hematol 26 (1998) 1093-1099
    • (1998) Exp Hematol , vol.26 , pp. 1093-1099
    • Sloand, E.1    Young, N.S.2    Sato, T.3    Kim, S.4    Maciejewski, J.P.5
  • 31
    • 16044365965 scopus 로고    scopus 로고
    • Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology
    • Socié G., Mary J.Y., de Gramont A., et al. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology. Lancet 348 (1996) 573-577
    • (1996) Lancet , vol.348 , pp. 573-577
    • Socié, G.1    Mary, J.Y.2    de Gramont, A.3
  • 32
    • 0030576926 scopus 로고    scopus 로고
    • Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system
    • Behrendt N., and Dano K. Effect of purified, soluble urokinase receptor on the plasminogen-prourokinase activation system. FEBS Lett 393 (1996) 31-36
    • (1996) FEBS Lett , vol.393 , pp. 31-36
    • Behrendt, N.1    Dano, K.2
  • 33
    • 0035884209 scopus 로고    scopus 로고
    • Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor
    • Hoyer-Hansen G., Pessara U., Holm A., et al. Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor. Biochem J 358 (2001) 673-679
    • (2001) Biochem J , vol.358 , pp. 673-679
    • Hoyer-Hansen, G.1    Pessara, U.2    Holm, A.3
  • 34
    • 8944221645 scopus 로고    scopus 로고
    • Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins
    • Higazi A.A., Upson R.H., Cohen R.L., et al. Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood 88 (1996) 542-551
    • (1996) Blood , vol.88 , pp. 542-551
    • Higazi, A.A.1    Upson, R.H.2    Cohen, R.L.3
  • 35
    • 33751181659 scopus 로고    scopus 로고
    • Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients
    • Tefs K., Gueorguieva M., Klammt J., et al. Molecular and clinical spectrum of type I plasminogen deficiency: a series of 50 patients. Blood 108 (2006) 3021-3026
    • (2006) Blood , vol.108 , pp. 3021-3026
    • Tefs, K.1    Gueorguieva, M.2    Klammt, J.3
  • 36
    • 0242494954 scopus 로고    scopus 로고
    • Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria (PNH)
    • Hall C., Richards S., and Hillmen P. Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria (PNH). Blood 102 (2003) 3587-3591
    • (2003) Blood , vol.102 , pp. 3587-3591
    • Hall, C.1    Richards, S.2    Hillmen, P.3
  • 37
    • 0026728730 scopus 로고
    • The effects of complement activation on platelets
    • Devine D.V. The effects of complement activation on platelets. Curr Top Microbiol Immunol 178 (1992) 101-113
    • (1992) Curr Top Microbiol Immunol , vol.178 , pp. 101-113
    • Devine, D.V.1
  • 38
    • 55549144062 scopus 로고    scopus 로고
    • The terminal complement inhibitor eculizumab reduces thrombosis in patients with paroxysmal nocturnal hemoglobinuria
    • Abstract
    • Hillmen P., Muus P., Duhrsen U., et al. The terminal complement inhibitor eculizumab reduces thrombosis in patients with paroxysmal nocturnal hemoglobinuria. Blood 108 (2007) 23 Abstract
    • (2007) Blood , vol.108 , pp. 23
    • Hillmen, P.1    Muus, P.2    Duhrsen, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.