Elevated levels of circulating procoagulant microparticles in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia

Blood

Volumn 93, Issue 10, 1999, Pages 3451-3456

  Hugel, Bénédicte ^b   Socié, Gérard ^b   Vu, Thi ^b   Toti, Florence ^b   Gluckman, Eliane ^b   Freyssinet, Jean Marie ^b   Scrobohaci, Marie Lorraine ^a  

^a Laboratoire Central d'Hematologie   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPID; PROCOAGULANT;

APLASTIC ANEMIA; ARTICLE; BLOOD FLOW; FIBRINOLYSIS; HEMOLYSIS; HUMAN; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PRIORITY JOURNAL; RISK; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOGENESIS;

EID: 0033562372     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.10.3451.410k27_3451_3456     Document Type: Article

References (29)

1. Rosse WF: Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria. Blood 75:1595, 1990
2. Griscelli-Bennaceur A, Gluckman E, Scrobohaci ML, Jonveaux P, Vu T, Bazarbachi A, Carosella ED, Sigaux F, Socié G: Aplastic anemia and paroxysmal nocturnal hemoglobinuria: Search for a pathogenetic link. Blood 85:1354, 1995
3. Socié G, Mary JY, de Gramont A, Rio B, Leporrier M, Rose C, Heudier P, Rochant H, Cahn JY, Gluckman E: Paroxysmal nocturnal haemoglobinuria: Long-term follow-up and prognostic factors. Lancet 348:573, 1996
4. Nakakuma H: Mechanism of intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). Am J Hematol 53:22, 1995
5. Plough M, Plesner T, Ronne E, Ellis V, Hoyer-Hansen G, Hansen NE, Dano K: The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. Blood 79:1447, 1992
6. Ninomiya H, Hasegawa Y, Nagasawa T, Abe T: Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity. Int J Hematol 65:285, 1997
7. Takahashi H, Izumi T, Toshima M, Kawano C, Komatsu N, Imagaua S, Hatake K, Madoiua S, Baba M, Sakata Y, Miura Y: Thrombotic complication in the course of aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome; possible involvement of dysplasminogenemia (plasminogen Tochigi) in the pathogenesis of thrombosis. Rinsho Ketsueki 37:249, 1996
8. Gralnick HR, Vail M, McKeown LP, Merryman P, Wilson O, Chu I, Kimball J: Activated platelets in paroxysmal nocturnal haemoglobinuria. Br J Haematol 91:697, 1995
9. Wiedmer T, Hall SE, Ortel TL, Kane WH, Rosse WF, Sims PJ: Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. Blood 82:1192, 1993
10. Martin SJ, Reutelingsperger CPM, McGahon AJ, Rader JA, van Schie RCA, Laface DM, Green DR: Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bc1-2 and Ab1. J Exp Med 182:1545, 1995
11. Aupeix K, Hugel B, Martin T, Bischoff P, Lill H, Pasquali JL, Freyssinet JM: The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. J Clin Invest 99:1546, 1997
12. Allen TM, Williamson P, Schlegel RA: Phosphatidylserine as a determinant of reticuloendothelial recognition of liposome models of the erythrocyte surface. Proc Natl Acad Sci USA 85:8067, 1988
13. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM: Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148:2207, 1992
14. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267:1456, 1995
15. Sims PJ, Faioni EM, Wiedmer T, Shattil SJ: Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem 263:18205, 1988
16. Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ: Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem 266:17261, 1991
17. Vu T, Griscelli-Bennaceur A, Gluckman E, Sigaux F, Carosella ED, Menier C, Scrobohaci ML, Socié G: Aplastic anemia and paroxysmal nocturnal hemoglobinuria: A study of the GPI-anchored proteins on human platelets. Br J Haematol 93:586, 1996
18. Toti F, Satta N, Fressinaud E, Meyer D, Freyssinet JM: Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications, is an inherited disorder. Blood 87:1409, 1996
19. Dachary-Prigent J, Freyssinet JM, Pasquet JM, Carron JC, Nurden AT: Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: A flow cytometry study showing a role for free sulfhydryl groups. Blood 81:2554, 1993
20. Rosing J, Bevers EM, Comfurius P, Hemker HC, van Dieijen G, Weiss HJ, Zwaal RFA: Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder. Blood 65:1557, 1985
21. 2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells. Cell 80:919, 1995
22. Tabibzadeh SS, Kong QF, Kapur S: Passive acquisition of leukocyte proteins is associated with changes in phosphorylation of cellular proteins and cell-cell adhesion properties. Am J Pathol 145:930, 1994
23. Parker CJ, Soldato CM, Rosse WF: Abnormality of glycophorinalpha on paroxysmal nocturnal hemoglobinuria erythrocytes. J Clin Invest 73:1130, 1984
24. Whitlow M, Lida K, Marshall P, Silber R, Nussenzweig V: Cells lacking glycan phosphatidylinositol-linked proteins have impaired ability to vesiculate. Blood 81:510, 1993
25. Horikawa K, Nakakuma H, Kawaguchi T, Iwamoto N, Nagakura S, Kagimoto T, Takatsuki K: Apoptosis resistance of blood cells from patients with paroxysmal nocturnal hemoglobinuria, aplastic anemia, and myelodysplastic syndrome. Blood 90:2716, 1997
26. Simons K, Ikonen E: Functional rafts in cell membranes. Nature 387:569, 1997
27. Rabesandratana H, Toutant JP, Reggio H, Vidai M: Decayaccelerating factor (CD55) and membrane inhibitor of reactive lysis (CD59) are released within exosomes during in vitro maturation of reticulocytes. Blood 91:2573, 1998
28. Kalafatis M, Rand MD, Mann KG: Factor Va-membrane interaction is mediated by two regions located on the light chain of the cofactor. Biochemistry 33:486, 1994
29. Jy W, Horstmann LL, Arce M, Ahn YS: Clinical significance of platelet microparticles in autoimmune thrombocytopenia. J Lab Clin Med 119:334, 1992