Lysis of plasma clots by urokinase-soluble urokinase receptor complexes

Blood

Volumn 92, Issue 6, 1998, Pages 2075-2083

  Higazi, Abd Al Roof ^a   Bdeir, Khalil ^b   Hiss, Edna ^b   Arad, Shira ^b   Kuo, Alice ^b   Barghouti, Lyad ^b   Cines, Douglas B ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN BINDING FACTOR; IMMUNOGLOBULIN G; PLASMINOGEN ACTIVATOR; UROKINASE; UROKINASE RECEPTOR;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; DISEASE ASSOCIATION; FIBRINOLYSIS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPRECIPITATION; INFECTION SENSITIVITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; WOUND HEALING;

EID: 0032530889     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.6.2075     Document Type: Article

References (55)

1. Odekon LE, Sato Y, Rifkin DB: Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J Cell Phys 150:258, 1992
2. Bacharach E, Itin A, Keshet E: In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiologic angiogenesis. Proc Natl Acad Sci USA 89:10686, 1992
3. Pepper MS, Belin D, Montesano R, Orci L, Vassalli J-D: Transforming growth factor-beta 1 modulated basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J Cell Biol 111:743, 1990
4. Van Hinsbergh VWM, Koolwijk P, Hanemaaijer R: Role of fibrin and plasminogen activators in repair-associated angiogenesis. In vitro studies with human endothelial cells, in Goldberg ID, Rosen EM (eds): Regulation of Angiogenesis. Basel, Switzerland, Birkhauser Verlag, 1997, p 391
5. Pepper MS, Sappino A-P, Stocklin R, Montesano R, Orci L, Vassalli J-D: Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol 122:673, 1993
6. Jensen PJ, Lavker RM: Modulation of the plasminogen activator cascade during enhanced epidermal proliferation in vivo. Cell Growth Differ 7:1793, 1996
7. Gyetko M, Chen G-H, McDonald RA, Goodman R, Huffnagle GB, Wilkinson CC, Fuller JA, Toews GB: Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model. JClin Invest 97:1818, 1996
8. Leonardsson G, Peng X-R, Liu K, Nordstrom L, Carmeliet P, Mulligan R, Collen D, Ny T: Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: Functional redundancy among physiologic plasminogen activators. Proc NatI Acaa Sci USA 92:12446, 1995
9. Sappino A-P, Huarte J, Belin D, Vassalli J-D: Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol 109:2471, 1989
10. Ny A, Nordstrom L, Carmeliet P, Ny T: Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency. Eur J Biochem 244:487, 1997
11. Clowes AW, Clowes MM, Au YPT, Reidy MA, Belin D: Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 67:61, 1990
12. Shireman PK. McCarthy WJ, Pearce WH, Shively PV, Cipollone M, Kwaan HC: Elevations of tissue-type plasminogen activator and differential expression of urokinase-type plasminogen activator in diseased aorta. J Vase Surg 25:157, 1997
13. Schneiderman J, Bordin GM, Engelberg I, Adar R, Seiffert D, Thinnes T, Bernstein EF, Dilley RB, Loskutoff DJ: Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion. J Clin Invest 96:639, 1995
14. Noda-Heiny H, Daugherty A, Sobel BE: Augmented urokinase receptor expression in atheroma. Arterioscler Thromb Vase Biol 15:37, 1995
15. Carmeliet P, Moons L, Hebert J-M, Crawley J, Lupu F, Lijnen R, Collen R: Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ Res 81:829, 1997
16. Nekarda H, Schmitt M, Ulm K, Wenninger A, Vogelsang H, Becker K, Roder JD, Fink U, Siewart JR: Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer. Cancer Res 54:2900, 1994
17. de Vries TJ, Quax PHA, Denijn M, Verrijp KM, Verheijen JH, Verspaget HW, Weidle UH, Ruiter DJ, van Muijen GNP: Plasminogen activators, their inhibitors, and urokinase receptors emerge in later stages of melanocytic tumor progression. Am J Pathol 144:70, 1994
18. Crowley CW, Cohen RL, Lucas BK, Lius G, Shuman MA, Levinson AD: Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci USA 90:5021, 1993
19. Yu W, Kim J, Ossowski L: Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy. J Cell Biol 137:767, 1997
20. Carmeliet P, Collen D: Genetic analysis of the plasminogen and coagulation system in mice. Haemost 26:132, 1996 (suppl 4)
21. Bugge TH, Flick MJ, Danton MJS, Daugherty CC, Romer J, Dano K, Carmeliet P, Collen D, Degen JL: Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue type plasminogen activator. Proc Natl Acad Sci USA 93:5899, 1996
22. Yamamoto K, Loskutoff DJ: Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue type plasminogen activator. J Clin Invest 97:2440, 1996
23. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degan J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC: Physiological consequences of loss of plasminogen activator gene function in mice. Nature 369:419, 1994
24. Kitching AR, Holdsworth SR, Ploplis VA, Plow EF, Collen D, Carmeliet P, Tipping PG: Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis. J Exp Med 185:963, 1997
25. Pannell R, Gurewich V: Activation of plasminogen by single- chain urokinase or by two-chain urokinase A demonstration that single-chain urokinase has a low catalytic activity (pro-urokinase). Blood 69:22, 1987
26. Husain SS: Single-chain urokinase-type plasminogen activator does not possess measurable intrinsic amidolytic or plasminogen activator activities. Biochem 30:5707, 1991
27. Liu J, Tang W, Sun Z-Y, Kung EW, Pannell R, Sarmientos P, Gurewich V: A site-directed mutagenesis of pro-urokinase which substantially reduces its intrinsic activity. Biochemistry 35:14070, 1995
28. Liu J, Gurewich V: A comparative study of the promotion of tissue plasminogen activator and pro-urokinase-induced plasminogen activation by fragments D and E-2 of fibrin. J Clin Invest 88:2012, 1991
29. Kasai S, Arimura H, Nishida M, Suyama T: Proteolytic cleavage of single chain prourokinase induces conformational change which follows activation of the zymogen and production of its high affinity to fibrin. J Biol Chem 260:12382, 1985
30. Sprengers ED, Kluft C: Plasminogen activator inhibitors. Blood 69:381, 1987
31. Lang IM, Schleef RR: Calcium-dependent stabilization of type I plasminogen activator inhibitor within platelet alpha-granules. J Biol Chem 271:2754, 1996
32. Schleef RR, Loskutoff DJ, Podor TJ: Tmmunoelectron microscopic localization of type 1 plasminogen activator inhibitor on the surface of activated endothelial cells. J Cell Biol 14:13, 1991
33. Lang IM, Marsh JJ, Olman MA, Moser KM, Loskutoff DJ, Schleef RR,: Expression of type I plasminogen activator inhibitor in chronic pulmonary emboli. Circulation 89:2715, 1994
34. Podor TJ, Butcher M, Foulon D, Lawrence DA, Stefasson S, Weitz JI: Disruption of vitronectin-mediated binding of plasminogen activator inhibitor-1 fibrin stimulates tissue-type plasminogen activator induced fibrinolysis. Fibrinol Proteolysis 11:22, 1997 (suppl 3, abstr)
35. Higazi AA-R, Cohen RL, Henkin J, Kniss D, Schwartz BS, Cines DB: Enhancement of the enzymatic activity of single-chain urokinase plasminogen activator by soluble urokinase receptor. J Biol Chem 270:17375, 1995
36. Wang J, Mazar A, Quan N, Schneider A, Henkin J: Plasminogen activation by pro-urokinase in complex with its receptor. Dependence on a tripeptide (Spectrazyme plasmin). Eur J Biochem 247:256, 1997
37. Moroz LA, Sniderman AD, Marpole DGF: Leukocyte-plasma interaction in fibrinolysis: A new dimension in the action of urokinase. N Engl J Med 301:1100, 1979
38. Henry RL: Leukocytes and thrombosis. Thromb Diath Haemorrh 13:35, 1965
39. Miles LA, Levin EG, Plescia J, Collen D, Plow EF: Plasminogen receptors, urokinase receptors, and their modulation on human endothelial cells. Blood 72:628, 1988
40. Herijgers N, Vettel U, Schaefer B, Spring H, Todd III RF, Kramer MD: Cell surface-bound urokinase-type plasminogen activator facilitates infiltration of freshly isolated granulocytes into fibrin matrix. Immunobiology 194:363, 1995
41. Ploug M, PlesnerT, Ronne E, Ellis V, Hoyer-Hansen G, Hansen NE, Dano K: The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. Blood 79:1447, 1992
42. Higazi AA-R, Mazar A, Wang J, Reilly R, Henkin J, Kniss D, Cines D: Single chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1. Blood 87:3545, 1996
43. Higazi AA-R, Cines DB: Regulation of single chain urokinase by small peptides. Thromb Res 84:243, 1996
44. Higazi AA-R, Mazar A, Wang J, Quan N, Griffin R, Reilly R, Henkin J, Cines DB: Soluble human urokinase receptor is composed of two active units. J Biol Chem 272:5348, 1997
45. Higazi AA-R, Upson R, Cohen R, McCrae KR, Manuppello J, Bognacki J, Henkin J, Kounnas M, Strickland D, Preissner KT, Lawler J, Cines DB: Interaction of single chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood 88:542, 1996
46. Silverstein RL, Leung LLK, Harpel PC, Nachman RL: Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J Clin Invest 74:1625, 1984
47. Deutch DG, Mertz ET: Plasminogen: Purification from plasma by affinity chromatography. Science 170:1095, 1970
48. Higazi AA-R, Barghouti II, Abu-Much R: Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. J Biol Chem 270:9472, 1995
49. Higazi AA-R, Aziza R, Samara AA, Mayer M: Regulation of fibrinolysis by non-esterified fatty acids. Biochem J 300:251, 1994
50. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680, 1970
51. Higazi AA-R, Finci-Yeheskel Z, Samara AA, Aziza R, Mayer M: Stimulation of plasmin activity by oleic acid. Biochem J 282:863, 1992
52. Ellis V, Wun TC, Behrendt B, Ronne E, Dano K: Inhibition of receptor-bound urokinase by plasminogen activator inhibitors. J Biol Chem 265:9904, 1990
53. Nelles L, Lijnen HR, Collen D, Holmes WE: Characterization of recombinant human single chain urokinase-type plasminogen activator mutants produced by site-specific mutagenesis of Lys 158. J Biol Chem 262:5682, 1987
54. Harpel PC, Sullivan R, Chang TS: Binding and activation of plasminogen on immobilized immunoglobulin G. Identification of the plasmin-derived Fab as the plasminogen-binding fragment. J Biol Chem 264:616, 1989
55. Gyetko MR, Todd III RF, Wilkinson CC, Sitrin RG: The urokinase receptor is required for human monocyte chemotaxis in vitro. J Clin Invest 93:1380, 1994