Effects of Iejimalide B, a marine macrolide, on growth and apoptosis in prostate cancer cell lines

Journal of Cellular Biochemistry

Volumn 105, Issue 4, 2008, Pages 998-1007

  Wang, Wei Lin Winnie ^a,b,c   McHenry, Peter ^a   Jeffrey, Randy ^a   Schweitzer, Dirk ^a   Helquist, Paul ^a   Tenniswood, Martin ^a,b,d  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY AT ALBANY   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cell cycle; Cell death; Cyclins; Marine macrolide

Indexed keywords

ANTINEOPLASTIC AGENT; BROXURIDINE; CRYSTAL VIOLET; CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; HYDROXYUREA; LEJIMALIDE B; MACROLIDE; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL FRACTIONATION; CELL STRAIN LNCAP; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; STEADY STATE; TUMOR GROWTH; WESTERN BLOTTING;

APOPTOSIS; CARBAMATES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; HUMANS; INTERPHASE; KINETICS; MACROLIDES; MALE; PROSTATIC NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 55549094126     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21898     Document Type: Article

References (28)

1. Adrian TE. 2007. Novel marine-derived anti-cancer agents. Curr Pharm Des 13:3417-3426.
2. Ali S, Aranha O, Pettit GR, Sarkar FH, Philip RA. 2003. Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. Cancer Chemother Pharmacol 52:235-246.
3. Amador ML, Jimeno J, Paz-Ares L, Cortes-Funes H, Hildago M. 2003. Progress in the development and acquisition of anticancer agents from marine sources. Ann Oncol 14:1607-1615.
4. Ambrosini G, Adida C, Altieri DC. 1997. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917-921.
5. Cazzalini O, Perucca P, Riva F, Stivala LA, Bianchi L, Vannini V, Ducommun B, Prosperi E. 2003. p21CDKN1A does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent binding of DNA polymerase delta at the G1/S phase transition. Cell Cycle 2:596-603.
6. Cragg G, Newmann DJ. 2005. Plants as a source of anti-cancer agents. J Ethnopharmacol 100:72-79.
7. Cuadrado A, Garcia-Fernandez LF, Gonzalez L, Suarez Y, Losada A, Alcaide V, Martinez T, Fernandez-Sousa JM, Sanchez-Puelles JM, Munoz A. 2003. Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK. J Biol Chem 278:241-250.
8. De Lorenzo MS, Yamaguchi K, Subbaramaiah K, Dannenberg AJ. 2003. Bryostatin-1 stimulates the transcription of cyclooxygenase-2: Evidence for an activator protein-1-dependent mechanism. Clin Cancer Res 9:5036-5043.
9. Fernandes F, Loura LM, Fedorov A, Dixon N, Kee TP, Prieto M, Hemminga MA. 2006. Binding assays of inhibitors towards selected V-ATPase domains. Biochim Biophys Acta 1758:1777-1786.
10. Fu WJ, Hu J, Spencer T, Carroll R, Wu G. 2005. Statistical models in assessing fold change of gene expression in real-time RT-PCR experiments. Comput Biol Chem 30:21-26.
11. Fürstner A, Nevado C, Waser M, Tremblay M, Chevrier C, Teplý F, Assa C, Waser M. 2007. Total synthesis of iejimalide A-D and assessment of the remarkable actin-depolymerizing capacity of these polyene macrolides. J Am Chem Soc 129:9150-9161.
12. Kazami S, Muroi M, Kawatani M, Kubota T, Usui T, Kobayashi J, Osada H. 2006. Iejimalides show anti-osteoclast activity via V-ATPase inhibition. Biosci Biotechnol Biochem 70:1364-1370.
13. Kikuchi Y, Ishibashi Y, Sasaki T, Kobayashi J. 1991. Iejimalides C and D, new antineoplastic 24-membered macrolide sulfates from the Okinawan marine tunicate Eudistoma cf. rigida. Tetrahedron Lett 32:797-798.
14. Kobayashi J, Cheng J, Ohta T, Nakamura H, Nozoe S, Hirata Y, Ohizumi Y, Sasaki T. 1988. Iejimalides A and B, novel 24 membered macrolides with potent anti-leukemic activity from the Okinawan tunicate Eudistoma cf rigida. J Org Chem 53:6147-6150.
15. König GM, Kehraus S, Seibert SF, Abdel-Lateff A, Müller D. 2006. Natural products from marine organisms and their associated microbes. ChemBioChem 7:229-238.
16. Krajewska M, Krajewski S, Banares S, Huang X, Turner B, Bubendorf L, Kallioniemi OP, Shabaik A, Vitiello A, Peehl D, Gao GJ, Reed JC. 2003. Elevated expression of inhibitor of apoptosis proteins in prostate cancer. Clin Cancer Res 9:4914-4925.
17. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.
18. Mayer AMS, Gustafson KR. 2006. Marine pharmacology in 2003-2004: Antitumour and cytotoxic compounds. Eur J Cancer 42:2241-2270.
19. Newmann DJ, Cragg GM. 2007. Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461-477.
20. Niculescu AB, Chen X, Smeets M, Hengst L, Prives C, Reed SI. 1998. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18:629-643.
21. Nozawa K, Tsuda M, Ishiyama H, Sasaki T, Tsuruo T, Kobayashi J. 2006. Absolute stereochemistry and antitumor activity of iejimalides. Bioorg Med Chem 14:1063-1067.
22. Nozell S, Chen X. 2002. p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family. Oncogene 21:1285-1294.
23. Roy S, Jeffrey R, Tenniswood M. 2008. Array based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. Mol Cancer Therap 7:1931-1939.
24. Schoonderwoert VT, Holthuis JC, Tanaka S, Tooze SA, Martens GJ. 2000. Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins. Eur J Biochem 267:5646-5654.
25. Schweitzer D, Kane JJ, Strand D, McHenry P, Tenniswood M, Helquist P. 2007. Total synthesis of iejimalide B. An application of the Shiina macrolactonization. Org Lett 9:4619-4622.
26. Sipkema D, Osinga R, Schatton W, Mendola D, Tramper J, Wijffels RH. 2005. Large-scale production of pharmaceuticals by marine sponges: Sea, cell, or synthesis? Biotechnol Bioeng 90:201-222.
27. Yarbro JW. 1992. Mechanism of action of hydroxyurea. Semin Oncol 19:1-10.
28. Zhang HM, Cheung P, Yanagawa B, McManus BM, Yang DC. 2003. BNips: A group of pro-apoptotic proteins in the Bcl-2 family. Apoptosis 8:229-236.