Large-scale production of pharmaceuticals by marine sponges: Sea, cell, or synthesis?

Biotechnology and Bioengineering

Volumn 90, Issue 2, 2005, Pages 201-222

  Sipkema, Detmer ^a   Osinga, Ronald ^a   Schatton, Wolfgang ^b   Mendola, Dominick ^c   Tramper, Johannes ^a   Wijffels, René H ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b KliniPharm GmbH   (Germany)

^c CalBioMarine Technologies   (United States)

Author keywords

Anticancer treatment; Avarol; Feasibility; Halichondrin B; Large scale production methods; Marine sponge; Psoriasis treatment

Indexed keywords

BIOMASS; CELL CULTURE; CELLS; CONCENTRATION (PROCESS); GENETIC ENGINEERING; SYNTHESIS (CHEMICAL);

GENETIC MODIFICATION; MARINE SPONGES; PSORIASIS; TECHNICAL ANALYSIS;

DRUG PRODUCTS;

AVAROL; BENGAMIDE; CONTIGNASTEROL; DISCODERMOLIDE; GIROLLINE; HALICHONDRIN B; HEMIASTERLIN A; HEMIASTERLIN B; IPL 576092; ISOHOMOHALICHONDRIN B; LAULIMALIDE; MANOALIDE; NEOAMPHIMEDINE; PELORUSIDE A; SALICYLHALIMIDE A; SALICYLHALIMIDE B; UNCLASSIFIED DRUG; VIDARABINE;

ARTICLE; BIOMASS; CELL CULTURE; CHEMICAL STRUCTURE; COST BENEFIT ANALYSIS; DNA MODIFICATION; DRUG ACTIVITY; DYSIDEA AVARA; ECONOMIC ASPECT; EX SITU CULTURE; FEASIBILITY STUDY; HARVEST; LARGE SCALE PRODUCTION; LISSODENDORYX; MARICULTURE; NONHUMAN; PHARMACEUTICS; PRIMMORPH CULTURE; PSORIASIS; SPONGE (PORIFERA); SYNTHESIS;

ANIMALS; ETHERS, CYCLIC; MARINE BIOLOGY; MODELS, BIOLOGICAL; MODELS, ECONOMIC; PHARMACEUTICAL PREPARATIONS; PORIFERA; SESQUITERPENES;

EID: 17644415708     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20404     Document Type: Article

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