A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces haem oxygenase-1 expression in human cells through a mechanism independent of hypoxia-inducible factor-1α

Journal of Biochemistry

Volumn 144, Issue 5, 2008, Pages 643-654

  Li, Bin ^a   Takeda, Kazuhisa ^a   Yokoyama, Satoru ^a,b   Shibahara, Shigeki ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Ethyl 3,4 dihydroxybenzoate; Haem oxygenase 1; Hypoxia; Hypoxia inducible factor 1 ; Prolyl hydroxylase inhibitor

Indexed keywords

ETHYL 3,4 DIHYDROXYBENZOATE; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL HYPOXIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HEME SYNTHESIS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; REGULATORY MECHANISM; UTERINE CERVIX CANCER;

ANOXIA; BENZOATES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ENZYME INHIBITORS; HEME OXYGENASE-1; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROCOLLAGEN-PROLINE DIOXYGENASE; PROMOTER REGIONS, GENETIC; RETINAL PIGMENT EPITHELIUM;

EID: 55349132388     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn115     Document Type: Article

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