The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role

Biochemistry

Volumn 47, Issue 44, 2008, Pages 11481-11489

  Bailey, Melanie L ^a   Shilton, Brian H ^a   Brandl, Christopher J ^a   Litchfield, David W ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; HYDROGEN; PROBABILITY DENSITY FUNCTION;

ACTIVE SITES; ACTIVITY RESULTS; CATALYTIC DOMAINS; CATALYTIC ROLES; DO-MAINS; DOMAIN STRUCTURES; DOUBLE MUTATIONS; HISTIDINE RESIDUES; HYDROGEN BONDING NETWORKS; HYDROGEN BONDINGS; ISOMERASE; ISOMERASE ACTIVITIES; PHOSPHORYLATED SUBSTRATES; PROTEIN STABILITIES; SEQUENCE CONSERVATIONS; YEAST COMPLEMENTATION;

HYDROGEN BONDS;

HISTIDINE; LEUCINE; PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE PIN1;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; ENZYME STABILITY; HISTIDINE; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDYLPROLYL ISOMERASE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 55249125918     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800964q     Document Type: Article

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