Critical importance of the nine-membered F ring of ciguatoxin for potent bioactivity: Total synthesis and biological evaluation of F-ring-modified analogues

Angewandte Chemie - International Edition

Volumn 47, Issue 45, 2008, Pages 8611-8614

  Inoue, Masayuki ^a   Lee, Nayoung ^b   Miyazaki, Keisuke ^b   Usuki, Toyonobu ^b   Matsuoka, Shigeru ^a   Hirama, Masahiro ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Biological activity; Medium ring compounds; Natural products; Structure activity relationships; Total synthesis

Indexed keywords

BIOCHEMISTRY; ETHERS; ORGANIC COMPOUNDS;

BIOLOGICAL ACTIVITY; MEDIUM-RING COMPOUNDS; NATURAL PRODUCTS; STRUCTURE-ACTIVITY RELATIONSHIPS; TOTAL SYNTHESIS;

BIOACTIVITY;

BREVETOXIN; CIGUATOXIN; DRUG DERIVATIVE; LIGAND; MARINE TOXIN; OXOCIN DERIVATIVE;

ANIMAL; ARTICLE; BRAIN; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; MOUSE; RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNAPTOSOME; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; BRAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CIGUATOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; LIGANDS; MARINE TOXINS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXOCINS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 55249118858     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200803921     Document Type: Article

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