Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 22, 2008, Pages 5955-5958

  Liu, Yongsheng ^a   Wu, Jiangyue ^a   Weissig, Helge ^a   Betancort, Juan M ^a   Gai, Wen Zhi ^a   Leventhal, Phillip S ^a   Patricelli, Matthew P ^a   Samii, Babak ^a   Szardenings, Anna K ^a   Shreder, Kevin R ^a   Kozarich, John W ^a  

^a ACTIVX BIOSCIENCES INC   (United States)

Author keywords

AX4697; Bisindolylmaleimide; Exo affinity label; Kinase probe; PKC ; PKC

Indexed keywords

AX 4697; BISINDOLYLMALEIMIDE; CALYCULIN A; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ASSAY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SYNTHESIS;

CATALYTIC DOMAIN; DRUG DESIGN; FLUORESCENT DYES; HUMANS; INDOLES; JURKAT CELLS; MALEIMIDES; MOLECULAR STRUCTURE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55249086702     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.045     Document Type: Article

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