Direct-current electrical field guides neuronal stem/progenitor cell migration

Stem Cells

Volumn 26, Issue 8, 2008, Pages 2193-2200

  Li, Lei ^a,b   El Hayek, Youssef H ^a   Liu, Baosong ^a   Chen, Yonghong ^a   Gomez, Everlyne ^a   Wu, Xiaohua ^a,b   Ning, Ke ^a   Li, Lijun ^a   Chang, Ning ^a   Zhang, Liang ^a   Wang, Zhengguo ^b   Hu, Xiang ^c   Wan, Qi ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c Shenzhen Beike Biotechnology Co Ltd   (China)

^d UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Direct current electrical fields; GTPase; Migration; N methyl D aspartate receptor; Neuronal stem progenitor cells

Indexed keywords

ACTIN; MEMBRANE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN REGION; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; ELECTRIC CURRENT; ELECTRIC FIELD; INTRACELLULAR MEMBRANE; NEURAL STEM CELL; NONHUMAN; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WISTAR RAT;

ACTINS; ANIMALS; AXONS; BRAIN; CELL MOVEMENT; CYTOSKELETON; ELECTRICITY; EMIGRATION AND IMMIGRATION; NEURONS; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 55049137072     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-1022     Document Type: Article

References (46)

1. Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature 2006;441:1094-1096.
2. Nadarajah B, Parnavelas JG. Modes of neuronal migration in the developing cerebral cortex. Nat Rev Neurosci 2002;3:423-432.
3. Doetsch F, Hen R. Young and excitable: The function of new neurons in the adult mammalian brain. Curr Opin Neurobiol 2005;15:121-128.
4. Alvarez-Buylla A, Lois C. Neuronal stem cells in the brain of adult vertebrates. STEM CELLS 1995;13:263-272.
5. Rakic P. Neurogenesis in adult primates. Prog Brain Res 2002;138:3-14.
6. Guan KL, Rao Y. Signalling mechanisms mediating neuronal responses to guidance cues. Nat Rev Neurosci 2003;4:941-956.
7. Ghashghaei HT, Lai C, Anton ES. Neuronal migration in the adult brain: Are we there yet? Nat Rev Neurosci 2007;8:141-151.
8. Lie DC, Song H, Colamarino SA et al. Neurogenesis in the adult brain: New strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol 2004;44:399-421.
9. Kolb B, Morshead C, Gonzalez C et al. Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats. J Cereb Blood Flow Metab 2007;27:983-997.
10. Parent JM, Vexler ZS, Gong C et al. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 2002;52:802-813.
11. Arvidsson A, Collin T, Kirik D et al. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002;8:963-970.
12. Teramoto T, Qiu J, Plumier JC et al. EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. J Clin Invest 2003;111:1125-1132.
13. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 2004;10(suppl):S42-S50.
14. Zhang RL, Zhang ZG, Zhang L et al. Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience 2001;105:33-41.
15. Dingledine R, Borges K, Bowie D et al. The glutamate receptor ion channels. Pharmacol Rev 1999;51:7-61.
16. Choi DW. Calcium: Still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 1995;18:58-60.
17. Loftis JM, Janowsky A. The N-methyl-D-aspartate receptor subunit NR2B: Localization, functional properties, regulation, and clinical implications. Pharmacol Ther 2003;97:55-85.
18. Komuro H, Kumada T. Ca2+ transients control CNS neuronal migration. Cell Calcium 2005;37:387-393.
19. Komuro H, Rakic P. Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. J Neurobiol 1998;37:110-130.
20. Bielas SL, Gleeson JG. Cytoskeletal-associated proteins in the migration of cortical neurons. J Neurobiol 2004;58:149-159.
21. Kawauchi T, Chihama K, Nabeshima Y et al. The in vivo roles of STEF/Tiam1, Rac1 and Jnk in cortical neuronal migration. EMBO J 2003;22:4190-4201.
22. Wong K, Ren XR, Huang YZ et al. Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 2001;107:209-221.
23. McCaig CD, Rajnicek AM, Song B et al. Controlling cell behavior electrically: Current views and future potential. Physiol Rev 2005;85:943-978.
24. Nuccitelli R. Endogenous electric fields in embryos during development, regeneration and wound healing. Radiat Prot Dosimetry 2003;106:375-383.
25. Borgens RB. Stimulation of neuronal regeneration and development by steady electrical fields. Adv Neurol 1988;47:547-564.
26. Shapiro S, Borgens R, Pascuzzi R et al. Oscillating field stimulation for complete spinal cord injury in humans: A phase 1 trial. J Neurosurg Spine 2005;2:3-10.
27. Zhu Y, Li H, Zhou L et al. Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Neuron 1999;23:473-485.
28. Zhao M, Agius-Fernandez A, Forrester JV et al. Orientation and directed migration of cultured corneal epithelial cells in small electric fields are serum dependent. J Cell Sci 1996;109:1405-1414.
29. Ning K, Pei L, Liao M et al. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. J Neurosci 2004;24:4052-4060.
30. Liu B, Liao M, Mielke JG et al. Ischemic insults direct glutamate receptor subunit 2-lacking AMPA receptors to synaptic sites. J Neurosci 2006;26:5309-5319.
31. Luo L. Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 2000;1:173-180.
32. Meyer G, Feldman EL. Signaling mechanisms that regulate actin-based motility processes in the nervous system. J Neurochem 2002;83:490-503.
33. Ehler E, van Leeuwen F, Collard JG et al. Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth. Mol Cell Neurosci 1997;9:1-12.
34. Manser E, Leung T, Salihuddin H et al. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 1994;367:40-46.
35. Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 2003;72:743-781.
36. Sells MA, Knaus UG, Bagrodia S et al. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 1997;7:202-210.
37. Zenke FT, King CC, Bohl BP et al. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem 1999;274:32565-32573.
38. King CC, Gardiner EM, Zenke FT et al. p21-activated kinase (Pak1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (Pdk1). J Biol Chem 2000;275:41201-41209.
39. Harris-Love ML, Cohen LG. Noninvasive cortical stimulation in neurorehabilitation: A review. Arch. Phys Med Rehabil 2006;87(suppl 2):S84-S93.
40. Settleman J. PAK-in' up cGMP for the move. Cell 2007;128:237-238.
41. Ayoob JC, Yu HH, Terman JR et al. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. J Neurosci 2004;24:6639-6649.
42. Bosgraaf L, Russcher H, Smith JL et al. A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. EMBO J 2002;21:4560-4570.
43. Postma M, Bosgraaf L, Loovers HM et al. Chemotaxis: Signalling modules join hands at front and tail. EMBO Rep 2004;5:35-40.
44. Guo D, Tan YC, Wang D et al. A Rac-cGMP signaling pathway. Cell 2007;128:341-355.
45. Rajnicek AM, Foubister LE, McCaig CD. Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field. J Cell Sci 2006;119:1723-1735.
46. Rajnicek AM, Foubister LE, McCaig CD. Growth cone steering by a physiological electric field requires dynamic microtubules, microfilaments and Rac-mediated filopodial asymmetry. J Cell Sci 2006;119:1736-1745.