Prevention by inhibitors of arachidonic acid cascade of liver carcinogenesis, cirrhosis and oxidative DNA damage caused by a choline- deficient, L-amino acid-defined diet in rats

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 402, Issue 1-2, 1998, Pages 279-288

  Denda, Ayumi ^a   Endoh, Takehiro ^a   Tang, Qing ^a,b   Tsujiuchi, Toshifumi ^a   Nakae, Dai ^a   Konishi, Yoichi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b Forensic Science Institute of Liaoning   (China)

Author keywords

8 Hydroxydeoxyguanosine; Choline deficient diet; Cyclooxygenase inhibitor; Inhibitor of arachidonic acid cascade; Liver cirrhosis; Rat hepatocarcinogenesis

Indexed keywords

4 BROMOPHENACYL BROMIDE; 8 HYDROXYDEOXYGUANOSINE; ACETYLSALICYLIC ACID; AMINO ACID; GLUTATHIONE TRANSFERASE; IBUPROFEN; INDOMETACIN; LIPOXYGENASE INHIBITOR; NORDIHYDROGUAIARETIC ACID; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; CANCER PREVENTION; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CIRRHOSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; VITAMIN DEFICIENCY;

AMINO ACIDS; ANIMALS; ARACHIDONIC ACID; BODY WEIGHT; CHOLINE DEFICIENCY; CYCLOOXYGENASE INHIBITORS; DEOXYGUANOSINE; DNA DAMAGE; FEEDING BEHAVIOR; GLUTATHIONE TRANSFERASE; LIPOXYGENASE INHIBITORS; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; PHOSPHOLIPASES A; RATS; RATS, INBRED F344;

EID: 0032543384     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00307-2     Document Type: Conference Paper

References (31)

1. [1] G.J. Kelloff, C.W. Boone, J.A. Crowell, V.E. Steele, R. Lubet, C.C. Sigman, Chemopreventive drug development: perspectives and progress, Cancer Epidemiol. Biomarkers Prev. 3 (1994) 85-98.
2. [2] P.M. Giardiello, S.R. Hamilton, A.J. Krush, S. Piantadosi, L.M. Hylind, P. Celano, S.V. Booker, C.R. Robinson, G.J. Offerhaus, Treatment of colonic and rectal adenoma with sulindac in familial adenomatous polyposis, New Engl. J. Med. 328 (1993) 1313-1316.
3. [3] L.J. Marnett, Aspirin and the potential role of prostaglandins in colon cancer, Cancer Res. 52 (1992) 5575-5589.
4. [4] A. Lupulescu, Prostaglandins, their inhibitors and cancer, Prostaglandins Leukotrienes Essent. Fatty Acids 54 (1996) 83-94.
5. [5] H.R. Herschman, Regulation of prostaglandin synthase-1 and prostaglandin synthase-2, Cancer Metastasis Rev. 13 (1994) 241-256.
6. [6] C.E. Eberhart, R.J. Coffey, A. Radhika, F.M. Giadiello, S. Ferrenbach, R.N. Dubois, Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas, Gastroenterology 107 (1994) 1183-1188.
7. [7] K. Müller-Decker, K. Scholz, F. Marks, G. Fürstenberger, Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis, Mol. Carcinogenesis 12 (1995) 31-41.
8. [8] X.-H. Liu, D.P. Rose, Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines, Cancer Res. 56 (1996) 5125-5127.
9. Δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2), Cell 87 (1996) 803-809.
10. [10] D.S. Alberts, L. Hixson, D. Ahnen, C. Bogert, J. Einspahr, N. Paranka, K. Brendel, P.H. Gross, R. Pamukcu, R.W. Burt, Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthase?, J. Cell. Biochem. 22 (1995) 18-23, (Suppl.).
11. [11] H. Shinozuka, S.L. Katyal, Pathology of choline deficiency, in: H. Sidransky (Ed.), Nutritional Pathology, Marcel Dekker, New York, 1985, pp. 279-320.
12. [12] A.K. Ghoshal, E. Farber, Choline-deficiency and the development of liver disease including liver cancer: a new perspective, Lab. Invest. 68 (1993) 255-260.
13. [13] T.H. Rushmore, D.M. Ghazarian, V. Subrahmanyan, E. Farber, A.K. Ghoshal, Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline-devoid low-methionine diet, Cancer Res. 47 (1987) 6731-6740.
14. [14] L.I. Hinrichsen, R.A. Floyd, O. Sudilovsky, Is 8-hydroxydeoxyguanosine a mediator of carcinogenesis by a choline-devoid diet in the rat liver?, Carcinogenesis 11 (1990) 1227-1233.
15. [15] D. Nakae, H. Yoshiji, Y. Mizumoto, K. Horiguchi, K. Shiraiwa, K. Tamura, A. Denda, Y. Konishi, High incidence of hepatocellular carcinomas induced by a choline-deficient, L-amino acid-defined diet in rats, Cancer Res. 52 (1992) 5042-5045.
16. [16] D. Nakae, H. Yoshiji, T. Kinugasa, A. Denda, Y. Konishi, Production of both 8-hydroxydeoxyguanosine in liver DNA and γ-glutamyltransferase-positive hepatocellular lesions in rats given a choline-deficient, L-amino acid-defined diet, Jpn. J. Cancer Res. 81 (1990) 1081-1084.
17. 2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats, Carcinogenesis 17 (1996) 467-475.
18. [18] K.-A. da Costa, S.C. Garner, J. Chang, S.H. Zeisel, Effects of prolonged (1 year) choline-deficiency and subsequent re-feeding of choline on 1,2-sn-diradylglycerol, fatty acids and protein kinase C in rat liver, Carcinogenesis 16 (1995) 327-334.
19. [19] K.-A. da Costa, E.F. Cochary, J.K. Blusztajn, S.C. Garner, S.H. Zeisel, Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous hepatocarcinogenesis in choline-deficient rats, J. Biol. Chem. 268 (1993) 2100-2105.
20. 2 and C in rat liver without affecting the activity of protein kinase C, J. Nutr. Biochem. 1 (1990) 434-439.
21. 2 in the liver of rats fed a choline deficient diet: possible involvement in liver tumor promotion, Cancer Lett. 46 (1989) 129-135.
22. [22] T. Adachi, S. Nakashima, S. Saji, T. Nakamura, Y. Nozawa, Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C, Hepatology 23 (1996) 1244-1253.
23. [23] A. Denda, Q. Tang, T. Endoh, T. Tsujiuchi, K. Horiguchi, O. Noguchi, Y. Mizumoto, D. Nakae, Y. Konishi, Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generation of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats, Carcinogenesis 15 (1994) 1279-1283.
24. [24] R.A. Squire, M.H. Levitt, Report of a workshop on classification of specific hepatocellular lesions in rats, Cancer Res. 35 (1975) 3214-3223.
25. [25] E. Kopp, S. Ghosh, Inhibition of NF-kB by sodium salicylate and aspirin, Science 265 (1994) 956-959.
26. [26] D. Laskin, Nonparenchymal cells and hepatotoxicity, Semin. Liver Dis. 10 (1990) 293-304.
27. [27] J. Quiroga, J. Prieto, Liver cytoprotection by prostaglandins, Pharmacol. Ther. 58 (1993) 67-92.
28. [28] P. Bedossa, K. Houglum, C. Trautwein, A. Holstege, M. Chojkier, Stimulation of collagen α 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis, Hepatology 19 (1994) 1262-1271.
29. [29] A. Van Der Vliet, A. Bast, Effects of oxidative stress on receptors and signal transmission, Chem.-Biol. Interact. 85 (1992) 95-116.
30. [30] I. Sakaida, Y. Matsumura, M. Kubota, K. Kayano, K. Takenaka, K. Okita, The propyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient, L-amino acid-defined diet, Hepatology 23 (1996) 755-763.
31. [31] M. Masuhara, S. Katyal, T. Nakamura, H. Shinozuka, Differential expression of hepatocyte growth factor, transforming growth factor-α and transforming growth factor-β messenger RNAs in two experimental models of liver cell proliferation, Hepatology 16 (1992) 1241-1249.