Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cells

Molecular and Cellular Biochemistry

Volumn 318, Issue 1-2, 2008, Pages 129-145

  Crinelli, Rita ^a   Bianchi, Marzia ^a   Menotta, Michele ^a   Carloni, Elisa ^a   Giacomini, Elisa ^a   Pennati, Marzia ^b   Magnani, Mauro ^a  

^a UNIVERSITY OF URBINO   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

E3 ligase activity; p53; Self ubiquitination; Ubiquitin pools

Indexed keywords

MYC PROTEIN; PROTEIN MDM2; PROTEIN P53; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E6AP; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY;

CATALYTIC DOMAIN; CELL CYCLE; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HELA CELLS; HUMANS; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-MDM2; THERMODYNAMICS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 54949108988     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9864-8     Document Type: Article

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