메뉴 건너뛰기




Volumn 105, Issue 3, 2008, Pages 913-921

Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation

Author keywords

Adipocyte; Cell cycle; Obesity; Proliferation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; F BOX PROTEIN; HELENALIN; MESSENGER RNA; PROTEASOME; PROTEIN P21;

EID: 54849433139     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21894     Document Type: Article
Times cited : (12)

References (38)
  • 1
    • 33744979761 scopus 로고    scopus 로고
    • Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes
    • Auld CA, Hopkins RG, Fernandes KM, Morrison RF. 2006. Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 346:314-320.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 314-320
    • Auld, C.A.1    Hopkins, R.G.2    Fernandes, K.M.3    Morrison, R.F.4
  • 2
    • 33847671842 scopus 로고    scopus 로고
    • Skp2-mediated p27(Kip1) degradation during S/G(2) phase progression of adipocyte hyperplasia
    • Auld CA, Fernandes KM, Morrison RF. 2007. Skp2-mediated p27(Kip1) degradation during S/G(2) phase progression of adipocyte hyperplasia. J Cell Physiol 211:101-111.
    • (2007) J Cell Physiol , vol.211 , pp. 101-111
    • Auld, C.A.1    Fernandes, K.M.2    Morrison, R.F.3
  • 3
    • 0037293541 scopus 로고    scopus 로고
    • NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes
    • Basile JR, Eichten A, Zacny V, Munger K. 2003. NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes. Mol Cancer Res 1:262-270.
    • (2003) Mol Cancer Res , vol.1 , pp. 262-270
    • Basile, J.R.1    Eichten, A.2    Zacny, V.3    Munger, K.4
  • 4
    • 0032511893 scopus 로고    scopus 로고
    • Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21
    • Cayrol C, Ducommun B. 1998. Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. Oncogene 17:2437-2444.
    • (1998) Oncogene , vol.17 , pp. 2437-2444
    • Cayrol, C.1    Ducommun, B.2
  • 5
    • 33645130336 scopus 로고    scopus 로고
    • Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells
    • Chang PY, Miyamoto S. 2006. Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells. Mol Cancer Res 4:101-112.
    • (2006) Mol Cancer Res , vol.4 , pp. 101-112
    • Chang, P.Y.1    Miyamoto, S.2
  • 6
    • 0033559264 scopus 로고    scopus 로고
    • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
    • Cheng M, Olivier P, Diehl JA, Fero M, Roussel MF, Roberts JM, Sherr CJ. 1999. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18:1571-1583.
    • (1999) EMBO J , vol.18 , pp. 1571-1583
    • Cheng, M.1    Olivier, P.2    Diehl, J.A.3    Fero, M.4    Roussel, M.F.5    Roberts, J.M.6    Sherr, C.J.7
  • 7
    • 0038219632 scopus 로고    scopus 로고
    • Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation
    • Coleman ML, Marshall CJ, Olson MF. 2003. Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J 22:2036-2046.
    • (2003) EMBO J , vol.22 , pp. 2036-2046
    • Coleman, M.L.1    Marshall, C.J.2    Olson, M.F.3
  • 8
    • 0037304898 scopus 로고    scopus 로고
    • New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment?
    • Coqueret O. 2003. New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment? Trends Cell Biol 13:65-70.
    • (2003) Trends Cell Biol , vol.13 , pp. 65-70
    • Coqueret, O.1
  • 9
    • 0034871746 scopus 로고    scopus 로고
    • Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis
    • Dirsch VM, Stuppner H, Vollmar AM. 2001a. Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis. Planta Med 67:557-559.
    • (2001) Planta Med , vol.67 , pp. 557-559
    • Dirsch, V.M.1    Stuppner, H.2    Vollmar, A.M.3
  • 10
    • 0035422774 scopus 로고    scopus 로고
    • Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bclx-(L) or Bcl-2
    • Dirsch VM, Stuppner H, Vollmar AM. 2001b. Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bclx-(L) or Bcl-2. Cancer Res 61:5817-5823.
    • (2001) Cancer Res , vol.61 , pp. 5817-5823
    • Dirsch, V.M.1    Stuppner, H.2    Vollmar, A.M.3
  • 11
    • 0034738420 scopus 로고    scopus 로고
    • p21(WAF1/Cip1): More than a break to the cell cycle?
    • Dotto GP. 2000. p21(WAF1/Cip1): More than a break to the cell cycle? Biochim Biophys Acta 1471:M43-M56.
    • (2000) Biochim Biophys Acta , vol.1471
    • Dotto, G.P.1
  • 12
    • 0035090385 scopus 로고    scopus 로고
    • Akt takes centre stage in cell-cycle deregulation
    • El Deiry WS. 2001. Akt takes centre stage in cell-cycle deregulation. Nat Cell Biol 3:E71-E73.
    • (2001) Nat Cell Biol , vol.3
    • El Deiry, W.S.1
  • 13
    • 0242576433 scopus 로고    scopus 로고
    • Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: Anti-inflammatory and cytotoxic effects
    • Gertsch J, Sticher O, Schmidt T, Heilmann J. 2003. Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: Anti-inflammatory and cytotoxic effects. Biochem Pharmacol 66:2141-2153.
    • (2003) Biochem Pharmacol , vol.66 , pp. 2141-2153
    • Gertsch, J.1    Sticher, O.2    Schmidt, T.3    Heilmann, J.4
  • 14
    • 0026578823 scopus 로고
    • The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells
    • Grippo AA, Hall IH, Kiyokawa H, Muraoka O, Shen YC, Lee KH. 1992. The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells. Drug Des Discov 8:191-206.
    • (1992) Drug Des Discov , vol.8 , pp. 191-206
    • Grippo, A.A.1    Hall, I.H.2    Kiyokawa, H.3    Muraoka, O.4    Shen, Y.C.5    Lee, K.H.6
  • 15
    • 0017334148 scopus 로고
    • Antitumor agents. 21. A. proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones
    • Hall IH, Lee KH, Mar EC, Starnes CO, Waddell TG. 1977. Antitumor agents. 21. A. proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones. J Med Chem 20:333-337.
    • (1977) J Med Chem , vol.20 , pp. 333-337
    • Hall, I.H.1    Lee, K.H.2    Mar, E.C.3    Starnes, C.O.4    Waddell, T.G.5
  • 16
    • 0018077292 scopus 로고
    • Antitumor agents XXX: Evaluation of alpha-methylene-gamma- lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis
    • Hall IH, Lee KH, Starnes CO, Eigebaly SA, Ibuka T, Wu YS, Kimura T, Haruna M. 1978. Antitumor agents XXX: Evaluation of alpha-methylene-gamma- lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis. J Pharm Sci 67:1235-1239.
    • (1978) J Pharm Sci , vol.67 , pp. 1235-1239
    • Hall, I.H.1    Lee, K.H.2    Starnes, C.O.3    Eigebaly, S.A.4    Ibuka, T.5    Wu, Y.S.6    Kimura, T.7    Haruna, M.8
  • 19
    • 23844468228 scopus 로고    scopus 로고
    • Potent inhibition of human telomerase by helenalin
    • Huang PR, Yeh YM, Wang TC. 2005. Potent inhibition of human telomerase by helenalin. Cancer Lett 227:169-174.
    • (2005) Cancer Lett , vol.227 , pp. 169-174
    • Huang, P.R.1    Yeh, Y.M.2    Wang, T.C.3
  • 20
    • 0346243936 scopus 로고    scopus 로고
    • MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
    • Jin Y, Lee H, Zeng SX, Dai MS, Lu H. 2003. MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J 22:6365-6377.
    • (2003) EMBO J , vol.22 , pp. 6365-6377
    • Jin, Y.1    Lee, H.2    Zeng, S.X.3    Dai, M.S.4    Lu, H.5
  • 23
    • 0030823162 scopus 로고    scopus 로고
    • Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB
    • Lyss G, Schmidt TJ, Merfort I, Pahl HL. 1997. Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. Biol Chem 378:951-961.
    • (1997) Biol Chem , vol.378 , pp. 951-961
    • Lyss, G.1    Schmidt, T.J.2    Merfort, I.3    Pahl, H.L.4
  • 24
    • 0001112989 scopus 로고    scopus 로고
    • The antiinflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65
    • Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I. 1998. The antiinflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem 273:33508-33516.
    • (1998) J Biol Chem , vol.273 , pp. 33508-33516
    • Lyss, G.1    Knorre, A.2    Schmidt, T.J.3    Pahl, H.L.4    Merfort, I.5
  • 25
    • 0033546003 scopus 로고    scopus 로고
    • Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis
    • Morrison RF, Farmer SR. 1999. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J Biol Chem 274:17088-17097.
    • (1999) J Biol Chem , vol.274 , pp. 17088-17097
    • Morrison, R.F.1    Farmer, S.R.2
  • 26
    • 10044265249 scopus 로고    scopus 로고
    • Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity
    • Naaz A, Holsberger DR, Iwamoto GA, Nelson A, Kiyokawa H, Cooke PS. 2004. Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. FASEB J 18:1925-1927.
    • (2004) FASEB J , vol.18 , pp. 1925-1927
    • Naaz, A.1    Holsberger, D.R.2    Iwamoto, G.A.3    Nelson, A.4    Kiyokawa, H.5    Cooke, P.S.6
  • 27
    • 0030927929 scopus 로고    scopus 로고
    • Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
    • Planas-Silva MD, Weinberg RA. 1997. Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol Cell Biol 17:4059-4069.
    • (1997) Mol Cell Biol , vol.17 , pp. 4059-4069
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 29
    • 0031037111 scopus 로고    scopus 로고
    • Regulation of adipose cell number in man
    • Prins JB, O'Rahilly S. 1997. Regulation of adipose cell number in man. Clin Sci (Lond) 92:3-11.
    • (1997) Clin Sci (Lond) , vol.92 , pp. 3-11
    • Prins, J.B.1    O'Rahilly, S.2
  • 30
    • 0033615003 scopus 로고    scopus 로고
    • Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway
    • Rousseau D, Cannella D, Boulaire J, Fitzgerald P, Fotedar A, Fotedar R. 1999. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway. Oncogene 18:4313-4325.
    • (1999) Oncogene , vol.18 , pp. 4313-4325
    • Rousseau, D.1    Cannella, D.2    Boulaire, J.3    Fitzgerald, P.4    Fotedar, A.5    Fotedar, R.6
  • 31
    • 0033624673 scopus 로고    scopus 로고
    • Nuclear factor kappaB subunits induce epithelial cell growth arrest
    • Seitz CS, Deng H, Hinata K, Lin Q, Khavari PA. 2000. Nuclear factor kappaB subunits induce epithelial cell growth arrest. Cancer Res 60:4085-4092.
    • (2000) Cancer Res , vol.60 , pp. 4085-4092
    • Seitz, C.S.1    Deng, H.2    Hinata, K.3    Lin, Q.4    Khavari, P.A.5
  • 32
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 33
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr CJ, Roberts JM. 2004. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18:2699-2711.
    • (2004) Genes Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 34
    • 0037417875 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis
    • Tang QQ, Otto TC, Lane MD. 2003a. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci 100:850-855.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 850-855
    • Tang, Q.Q.1    Otto, T.C.2    Lane, M.D.3
  • 35
    • 0037422569 scopus 로고    scopus 로고
    • Mitotic clonal expansion: A synchronous process required for adipogenesis
    • Tang QQ, Otto TC, Lane MD. 2003b. Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc Natl Acad Sci 100:44-49.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 44-49
    • Tang, Q.Q.1    Otto, T.C.2    Lane, M.D.3
  • 36
    • 0035872863 scopus 로고    scopus 로고
    • A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome
    • Touitou R, Richardson J, Bose S, Nakanishi M, Rivett J, Allday MJ. 2001. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome. EMBO J 20:2367-2375.
    • (2001) EMBO J , vol.20 , pp. 2367-2375
    • Touitou, R.1    Richardson, J.2    Bose, S.3    Nakanishi, M.4    Rivett, J.5    Allday, M.J.6
  • 38
    • 1942437554 scopus 로고    scopus 로고
    • MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53
    • Zhang Z, Wang H, Li M, Agrawal S, Chen X, Zhang R. 2004. MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem 279:16000-16006.
    • (2004) J Biol Chem , vol.279 , pp. 16000-16006
    • Zhang, Z.1    Wang, H.2    Li, M.3    Agrawal, S.4    Chen, X.5    Zhang, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.