Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase

ChemMedChem

Volumn 3, Issue 10, 2008, Pages 1535-1538

  Hofmann, Bettina ^a   Franke, Lutz ^a   Proschak, Ewgenij ^a   Tanrikulu, Yusuf ^a   Schneider, Petra ^b   Steinhilber, Dieter ^a   Schneider, Gisbert ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Schneider Consulting GbR   (Germany)

Author keywords

Bioisosters; Cheminformatics; Drug discovery; Inflammation; Virtual screening

Indexed keywords

ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; IMIDAZOLE DERIVATIVE; LIPOXYGENASE INHIBITOR;

ARTICLE; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION;

ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CELLS, CULTURED; DRUG DESIGN; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; LIPOXYGENASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54849408377     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800153     Document Type: Article

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