-
1
-
-
0033863020
-
Nonsteroidal anti-inflammatory drug gastropathy
-
Hawkey CJ. Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 2000; 119: 521-535.
-
(2000)
Gastroenterology
, vol.119
, pp. 521-535
-
-
Hawkey, C.J.1
-
2
-
-
0033594911
-
Nonsteroidal drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
-
Warner TD, Giuliano F, Vojnovic I et al. Nonsteroidal drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999; 96: 7563-7566.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7563-7566
-
-
Warner, T.D.1
Giuliano, F.2
Vojnovic, I.3
-
3
-
-
0029866858
-
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation
-
Nickerson-Nutter CL, Medvedeff ED. The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis Rheum 1996; 39: 515-521.
-
(1996)
Arthritis Rheum.
, vol.39
, pp. 515-521
-
-
Nickerson-Nutter, C.L.1
Medvedeff, E.D.2
-
4
-
-
0034946179
-
Redox inhibitors: Discovery and development of ML3000
-
Laufer S. Redox inhibitors: discovery and development of ML3000. Inflammopharmacology 2001; 9: 101-112.
-
(2001)
Inflammopharmacology
, vol.9
, pp. 101-112
-
-
Laufer, S.1
-
5
-
-
0028289770
-
(6,7-diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase
-
Laufer SA, Augustin J, Dannhardt G, Kiefer W. (6,7-diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Medicinal Chem 1994; 37: 1894-1897.
-
(1994)
J. Medicinal Chem.
, vol.37
, pp. 1894-1897
-
-
Laufer, S.A.1
Augustin, J.2
Dannhardt, G.3
Kiefer, W.4
-
6
-
-
0028322243
-
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase
-
Laufer S, Tries S, Augustin J, Dannhardt G. Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase. Arzneimittel Forschung 1994; 44(1): 629-636.
-
(1994)
Arzneimittel Forschung
, vol.44
, Issue.1
, pp. 629-636
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
Dannhardt, G.4
-
7
-
-
0038191002
-
4 in the anormal function of human subchondral osteoarthritic osteoblasts: Effects of the combined inhibition of cyclooxygenase and 5-lipoygenase (5-LO) by licofelone (ML-3000)
-
THU0199
-
4 in the anormal function of human subchondral osteoarthritic osteoblasts: effects of the combined inhibition of cyclooxygenase and 5-lipoygenase (5-LO) by licofelone (ML-3000). Ann Rheum Dis 2002; 61: THU0199.
-
(2002)
Ann. Rheum. Dis.
, vol.61
-
-
Lajeunesswe, D.1
Paredes, Y.2
Massicotte, F.3
-
8
-
-
0031172919
-
The effects of ML 3000 on antigen-induced responses in sheep
-
Abraham WM, Laufer S, Tries S. The effects of ML 3000 on antigen-induced responses in sheep. Pulm Pharmacol Ther 1997; 10: 167-173.
-
(1997)
Pulm. Pharmacol. Ther.
, vol.10
, pp. 167-173
-
-
Abraham, W.M.1
Laufer, S.2
Tries, S.3
-
9
-
-
0034863527
-
Dual inhibition of 5-lipoxygenase and cyclooxygenase 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis
-
Gay RE, Neidhart M, Pataky F et al. Dual inhibition of 5-lipoxygenase and cyclooxygenase 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis. J Rheumatol 2001; 28: 2060-2065.
-
(2001)
J. Rheumatol.
, vol.28
, pp. 2060-2065
-
-
Gay, R.E.1
Neidhart, M.2
Pataky, F.3
-
10
-
-
0034757607
-
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis
-
Jovanovic DV, Fernandes JC, Martel-Pelletier J et al. In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis. Arthritis Rheum 2001; 44: 2320-2330.
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 2320-2330
-
-
Jovanovic, D.V.1
Fernandes, J.C.2
Martel-Pelletier, J.3
-
11
-
-
0037515683
-
The in vivo inhibition of cylooxygenase and 5-lipoxygenase by licofelone (ML-3000) reduces the progression of experimental osteoarthritis: Suppression of collagenase-11 and interleukin-1β synthesis
-
THU0191
-
Pelletier JP, Fernandes JC, Jolicoeur F-C et al. The in vivo inhibition of cylooxygenase and 5-lipoxygenase by licofelone (ML-3000) reduces the progression of experimental osteoarthritis: suppression of collagenase-11 and interleukin-1β synthesis. Ann Rheum Dis 2002; 61: THU0191.
-
(2002)
Ann. Rheum. Dis.
, vol.61
-
-
Pelletier, J.P.1
Fernandes, J.C.2
Jolicoeur, F.-C.3
-
12
-
-
0038529749
-
Licofelone (ML-3000), a dual inhibitor of both 5-lipoxygenase and cyclooxygenases, reduces the level of cartilage chondrycyte death in vivo in experimental dog osteoarthritis: Inhibition of pro-apoptotic factors
-
THU0198
-
Pelletier JP, Boileau C, Jouzeau JY et al. Licofelone (ML-3000), a dual inhibitor of both 5-lipoxygenase and cyclooxygenases, reduces the level of cartilage chondrycyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. Ann Rheum Dis 2002; 61: THU0198.
-
(2002)
Ann. Rheum. Dis.
, vol.61
-
-
Pelletier, J.P.1
Boileau, C.2
Jouzeau, J.Y.3
-
13
-
-
0038328335
-
First clinical results of licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis
-
THU0189
-
Reginster J, Bias P, Buchner A. First clinical results of licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis. Ann Rheum Dis 2002; 61: THU0189.
-
(2002)
Ann. Rheum. Dis.
, vol.61
-
-
Reginster, J.1
Bias, P.2
Buchner, A.3
-
14
-
-
0027294984
-
Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs
-
Hudson N, Balsitis M, Everitt S, Hawkey CJ. Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut 1993; 34: 742-747.
-
(1993)
Gut
, vol.34
, pp. 742-747
-
-
Hudson, N.1
Balsitis, M.2
Everitt, S.3
Hawkey, C.J.4
-
15
-
-
0027182858
-
Investigations of indomethacin-induced gastric ulcer in rats
-
Kapui Z, Boer K, Rozsa I et al. Investigations of indomethacin-induced gastric ulcer in rats. Drug Res 1993; 43: 767-771.
-
(1993)
Drug Res.
, vol.43
, pp. 767-771
-
-
Kapui, Z.1
Boer, K.2
Rozsa, I.3
-
16
-
-
0032932028
-
Inhibition by leukotriene inhibitors and calcium and platelet activating factor antagonists of acute gastric and intestinal damage in arthritic rats and in cholinomimetic treated mice
-
Rainsford KD. Inhibition by leukotriene inhibitors and calcium and platelet activating factor antagonists of acute gastric and intestinal damage in arthritic rats and in cholinomimetic treated mice. J Pharm Pharmacol 1999; 51: 331-339.
-
(1999)
J. Pharm. Pharmacol.
, vol.51
, pp. 331-339
-
-
Rainsford, K.D.1
-
17
-
-
0027236493
-
Leukotrienes in the pathogenesis of NSAID-induced gastric intestinal mucosal damage
-
Rainsford KD. Leukotrienes in the pathogenesis of NSAID-induced gastric intestinal mucosal damage. Agents Actions 1993; 39: C24-C26.
-
(1993)
Agents Actions
, vol.39
-
-
Rainsford, K.D.1
-
18
-
-
0026579528
-
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy
-
Vaananen PM, Keenan CM, Grisham MB, Wallace JL. Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation 1992; 16: 227-240.
-
(1992)
Inflammation
, vol.16
, pp. 227-240
-
-
Vaananen, P.M.1
Keenan, C.M.2
Grisham, M.B.3
Wallace, J.L.4
-
19
-
-
0034801410
-
Neutrophils, endothelial cells, and cysteinyl leukotrienes: A new approach to neutrophil-dependent inflammation?
-
Sala A, Folco G. Neutrophils, endothelial cells, and cysteinyl leukotrienes: a new approach to neutrophil-dependent inflammation? Biochem Biophys Res Commun 2001; 283: 1003-1006.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.283
, pp. 1003-1006
-
-
Sala, A.1
Folco, G.2
-
20
-
-
0028597003
-
ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury
-
Wallace JL, Carter L, McKnight W et al. ML 3000 reduces gastric prostaglandin synthesis without causing mucosal injury. Eur J Pharmacol 1994; 271: 525-531.
-
(1994)
Eur. J. Pharmacol.
, vol.271
, pp. 525-531
-
-
Wallace, J.L.1
Carter, L.2
McKnight, W.3
-
21
-
-
0028223390
-
Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the fed rat
-
Trevethick MA, Clayton NM, Bahl AK et al. Leukotrienes do not contribute to the pathogenesis of indomethacin-induced ulceration of the gastric antrum in the fed rat. Agents Actions 1994; 41: 179-183.
-
(1994)
Agents Actions
, vol.41
, pp. 179-183
-
-
Trevethick, M.A.1
Clayton, N.M.2
Bahl, A.K.3
-
22
-
-
0026661824
-
Nonessential role of leukotrienes as mediators of acute gastric mucosal injury induced by aspirin in rats
-
Lee M, Feldman M. Nonessential role of leukotrienes as mediators of acute gastric mucosal injury induced by aspirin in rats. Dig Dis Sci 1992; 37: 1282-1287.
-
(1992)
Dig. Dis. Sci.
, vol.37
, pp. 1282-1287
-
-
Lee, M.1
Feldman, M.2
-
23
-
-
0028675272
-
Gastrointestinal tolerance of [2,2-Diomethyl-6-(4-chlorophenyl-7-phenyl-2, 3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the eat
-
Laufer S, Tries S, Augustin J et al. Gastrointestinal tolerance of [2,2-Diomethyl-6-(4-chlorophenyl-7-phenyl-2, 3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the eat. Arzneimittel-Forschung 1994; 44(II): 1329-1333.
-
(1994)
Arzneimittel-Forschung
, vol.44
, Issue.2
, pp. 1329-1333
-
-
Laufer, S.1
Tries, S.2
Augustin, J.3
-
24
-
-
0009520840
-
A dual cyclo- and lipooxygenase inhibitor, ML3000 spares gastric mucosa in aspirin-treated rats
-
Fiorucci S, Distrutti E, Mencarelli A et al. A dual cyclo- and lipooxygenase inhibitor, ML3000 spares gastric mucosa in aspirin-treated rats. Gut 2001; 49(suppl III).
-
(2001)
Gut
, vol.49
, Issue.SUPPL. III
-
-
Fiorucci, S.1
Distrutti, E.2
Mencarelli, A.3
-
25
-
-
0037515684
-
Licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, has little or no effect on the gastric mucosa after four weeks of treatment
-
THU0243
-
Klesser B, Bias P, Buchner A. Licofelone (ML3000), an inhibitor of COX-1, COX-2 and 5-LOX, has little or no effect on the gastric mucosa after four weeks of treatment. Ann Rheum Dis 2002; 61: THU0243.
-
(2002)
Ann. Rheum. Dis.
, vol.61
-
-
Klesser, B.1
Bias, P.2
Buchner, A.3
-
26
-
-
0035833502
-
The coxibs, selective inhibitors of cyclooxygenase-2
-
FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001; 345: 433-442.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 433-442
-
-
FitzGerald, G.A.1
Patrono, C.2
-
27
-
-
0034707105
-
Comparison of upper gastrointestinal toxicity of rofeCOXib and naproxen in patients with rheumatoid arthritis
-
VIGOR Study Group
-
Bombardier C, Laine L, Reicin A et al. Comparison of upper gastrointestinal toxicity of rofeCOXib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000; 343: 1520-1528.
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1520-1528
-
-
Bombardier, C.1
Laine, L.2
Reicin, A.3
|