Differential transactivation by orphan nuclear receptor NOR1 and its fusion gene product EWS/NOR1: Possible involvement of poly(ADP-ribose) polymerase I, PARP-1

Journal of Cellular Biochemistry

Volumn 105, Issue 3, 2008, Pages 785-800

  Ohkura, Naganari ^a   Nagamura, Yuko ^a   Tsukada, Toshihiko ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Chromosomal translocation; EWS NOR1; NOR1; NR4A family; PARP 1

Indexed keywords

CELL NUCLEUS RECEPTOR; DNA BINDING PROTEIN; HYBRID PROTEIN; LUCIFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; ORPHAN NUCLEAR RECEPTOR NOR1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; FUSION GENE; GENE CONTROL; GENE OVEREXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; UPREGULATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MICE; ONCOGENE PROTEINS, FUSION; POLY(ADP-RIBOSE) POLYMERASES; RECEPTORS, STEROID; RECEPTORS, THYROID HORMONE; RNA-BINDING PROTEIN EWS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 54849405737     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21876     Document Type: Article

References (41)

1. Bandoh S, Tsukada T, Maruyama K, Ohkura N, Yamaguchi K. 1997. Mechanical agitation induces gene expression of NOR-1 and its closely related orphan nuclear receptors in leukemic cell lines. Leukemia 11:1453-1458.
2. Cervellera MN, Sala A. 2000. Poly(ADP-ribose) polymerase is a B-MYB coactivator. J Biol Chem 275:10692-10696.
3. Cheng LE-C, Chan FK-M, Cado D, Winoto A. 1997. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J 16:1865-1875.
4. Clark J, Benjamin H, Gill S, Sidhar S, Goodwin G, Crew J, Gusterson BA, Shipley J, Cooper CS. 1996. Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene 12:229-235.
5. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G, Aurias A, Thomas G. 1992. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359:162-165.
6. Drouin J, Maira M, Philips A. 1998. Novel mechanism of action for Nur77 and antagonism by glucocorticoids: A convergent mechanism for CRH activation and glucocorticoid repression of POMC gene transcription. J Steroid Biochem Mol Biol 65:59-63.
7. Filion C, Labelle Y. 2004. The oncogenic fusion protein EWS/NOR-1 induces transformation of CFK2 chondrogenic cells. Exp Cell Res 297:585-592.
8. Ghabreau L, Roux JP, Frappart PO, Mathevet P, Patricot LM, Mokni M, Korbi S, Wang ZQ, Tong WM, Frappart L. 2004. Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. Int J Cancer 109:317-321.
9. Hassa PO, Buerki C, Lombardi C, Imhof R, Hottiger MO. 2003. Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J Biol Chem 278:45145-45153.
10. Janknecht R. 2005. EWS-ETS oncoproteins: The linchpins of Ewing tumors. Gene 363:1-14.
11. Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN. 1995. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 10:1229-1234.
12. Kagaya S, Ohkura N, Tsukada T, Miyagawa M, Sugita Y, Tsujimoto G, Matsumoto K, Saito H, Hashida R. 2005. Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamily. Biol Pharm Bull 28:1603-1607.
13. Labelle Y, Zucman J, Stenman G, Kindblom L-G, Knight J, Turc-Carel C, Dockhorn-Dworniczak B, Mandahl N, Desmaze C, Peter M, Aurias A, Delattre O, Thomas G. 1995. Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. Hum Mol Genet 4:2219-2226.
14. Labelle Y, Bussieres J, Courjal F, Goldring MB. 1999. The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator. Oncogene 18:3303-3308.
15. Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y. 2003. The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. Cancer Res 63:449-454.
16. Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM. 2004. Negative modulation of androgen receptor transcriptional activity by Daxx. Mol Cell Biol 24:10529-10541.
17. Maira M, Martens C, Batsche E, Gauthier Y, Drouin J. 2003. Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol 23:763-776.
18. Mix KS, Attur MG, Al-Mussawir H, Abramson SB, Brinckerhoff CE, Murphy EP. 2007. Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage. J Biol Chem 282:9492-9504.
19. Miyamoto T, Kakizawa T, Hashizume K. 1999. Inhibition of nuclear receptor signalling by poly(ADP-ribose) polymerase. Mol Cell Biol 19:2644-2649.
20. Mullican SE, Zhang S, Konopleva M, Ruvolo V, Andreeff M, Milbrandt J, Conneely OM. 2007. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med 13:730-735.
21. Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D. 2006. The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J Biol Chem 281:33467-33476.
22. Oei SL, Griesenbeck J, Schweiger M, Ziegler M. 1998. Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors. J Biol Chem 273:31644-31647.
23. Ohkura N, Hijikuro M, Yamamoto A, Miki K. 1994. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem Biophys Res Commun 205:1959-1965.
24. Ohkura N, Hosono T, Maruyama K, Tsukada T, Yamaguchi K. 1999. An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling. Biochim Biophys Acta 1444:69-79.
25. Ohkura N, Yaguchi H, Tsukada T, Yamaguchi K. 2002. The EWS/NOR1 fusion gene product gains a novel activity affecting pre-mRNA splicing. J Biol Chem 277:535-543.
26. Ohno T, Ouchida M, Lee L, Gatalica Z, Rao VN, Reddy ES. 1994. The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. Oncogene 9:3087-3097.
27. Oikawa T. 2004. ETS transcription factors: Possible targets for cancer therapy. Cancer Sci 95:626-633.
28. Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, Tempst P, de Murcia G, Evans R, Chambon P, Reinberg D. 2005. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell 18:83-96.
29. Philips A, Lesage S, Gingras R, Maira M-H, Gauthier Y, Hugo P, Drouin J. 1997. Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Mol Cell Biol 17:5946-5951.
30. Rawling JM, Alvarez-Gonzalez R. 1997. TFIIF, a basal eukaryotic transcription factor, is a substrate for poly(ADP-ribosyl)ation. Biochem J 324(Pt 1):249-253.
31. Shatnawi A, Tran T, Ratnam M. 2007. R5020 and RU486 act as progesterone receptor agonists to enhance Sp1/Sp4-dependent gene transcription by an indirect mechanism. Mol Endocrinol 21:635-650.
32. Simonin F, Poch O, Delarue M, de Murcia G. 1993. Identification of potential active-site residues in the human poly(ADP-ribose) polymerase. J Biol Chem 268:8529-8535.
33. Sjogren H, Meis-Kindblom JM, Orndal C, Bergh P, Ptaszynski K, Aman P, Kindblom LG, Stenman G. 2003. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses. Am J Pathol 162:781-792.
34. Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. 1994. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 6:146-151.
35. Stenman G, Andersson H, Mandahl N, Meis-Kindblom JM, Kindblom LG. 1995. Translocation t(9;22)(q22;q12) is a primary cytogenetic abnormality in extraskeletal myxoid chondrosarcoma. Int J Cancer 62:398-402.
36. Subramanian S, West RB, Marinelli RJ, Nielsen TO, Rubin BP, Goldblum JR, Patel RM, Zhu S, Montgomery K, Ng TL, Corless CL, Heinrich MC, van de Rijn M. 2005. The gene expression profile of extraskeletal myxoid chondrosarcoma. J Pathol 206:433-444.
37. Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ. 2007. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol 27:7918-7934.
38. Wilson TE, Fahrner TJ, Johnston M, Milbrandt J. 1991. Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252:1296-1300.
39. Yaguchi H, Ohkura N, Takahashi M, Nagamura Y, Kitabayashi I, Tsukada T. 2004. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol 24:6569-6580.
40. Zetterstrom RH, Solomin L, Mitsiadis T, Olson L, Perlmann T. 1996. Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1. Mol Endocrinol 10:1656-1666.
41. Zhang L, Eddy A, Teng YT, Fritzler M, Kluppel M, Melet F, Bernstein A. 1995. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Mol Cell Biol 15:6961-6970.