An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1444, Issue 1, 1999, Pages 69-79

  Ohkura, Naganari ^a   Hosono, Tetsuji ^a   Maruyama, Kouji ^a   Tsukada, Toshihiko ^a   Yamaguchi, Ken ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Alternative splicing; Isoform; NGFI B family; Nurr1

Indexed keywords

CELL NUCLEUS RECEPTOR; FORSKOLIN; NERVE GROWTH FACTOR RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; QUANTITATIVE DIAGNOSIS; RAT; REGULATOR GENE; REPORTER GENE; TRANSCRIPTION REGULATION;

3T3 CELLS; ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; FORSKOLIN; GENE EXPRESSION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033579988     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4781(98)00247-4     Document Type: Article

References (30)

1. J. Milbrandt, Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene, Neuron 1 (1988) 183-188.
2. T.G. Hazel, D. Nathans, L.F. Lau, A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily, Proc. Natl. Acad. Sci. USA 85 (1988) 8444-8448.
3. C. Chang, J. Kokontis, S.S. Liao, Y. Chang, Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily, J. Steroid Biochem. 34 (1989) 391-395.
4. S.W. Law, O.M. Conneely, F.J. DeMayo, B.W. O'Malley, Identification of a new brain-specific transcription factor, NURR1, Mol. Endocrinol. 6 (1992) 2129-2135.
5. L.M. Scearce, T.M. Laz, T.G. Hazel, L.F. Lau, R. Taub, RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver, J. Biol. Chem. 268 (1993) 8855-8861.
6. N. Ohkura, M. Hijikuro, A. Yamamoto, K. Miki, Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells, Biochem. Biophys. Res. Commun. 205 (1994) 1959-1965.
7. J. Clark, H. Benjamin, S. Gill, S. Sidhar, G. Goodwin, J. Crew, B.A. Gusterson, J. Shipley, C.S. Cooper, Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma, Oncogene 12 (1996) 229-235.
8. Y. Labelle, J. Zucman, G. Stenman, L.-G. Kindblom, J. Knight, C. Turc-Carel, B. Dockhorn-Dworniczak, N. Mandahl, C. Desmaze, M. Peter, A. Aurias, O. Delattre, G. Thomas, Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation, Hum. Mol. Genet. 4 (1995) 2219-2226.
9. G.T. Williams, L.F. Lau, Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses, Mol. Cell. Biol. 13 (1993) 6124-6136.
10. P.A. Crawford, Y. Sadovsky, K. Woodson, S.L. Lee, J. Milbrandt, Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice, Mol. Cell. Biol. 15 (1995) 4331-4336.
11. Z.-G. Liu, S.W. Smith, K.A. McLaughlin, L.M. Schwartz, B.A. Osborne, Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77, Nature 367 (1994) 281-284.
12. J.D. Woronicz, B. Calnan, V. Ngo, A. Winoto, Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas, Nature 367 (1994) 277-281.
13. R.H. Zetterström, L. Solomin, L. Jansson, B.J. Hoffer, L. Olson, T. Perlmann, Dopamine neuron agenesis in Nurr1-deficient mice, Science 276 (1997) 248-250.
14. T.E. Wilson, R.E. Paulsen, K.A. Padgett, J. Milbrandt, Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors, Science 256 (1992) 107-110.
15. T.E. Wilson, T.J. Fahrner, M. Johnston, J. Milbrandt, Identification of the DNA binding site for NGFI-B by genetic selection in Yeast, Science 25 (1991) 1296-1300.
16. K. Maruyama, T. Tsukada, S. Bandoh, K. Sasaki, N. Ohkura, K. Yamaguchi, Expression of the putative transcription factor NOR-1 in the nervous, the endocrine and the immune systems and the developing brain of the rat, Neuroendocrinology 65 (1997) 2-8.
17. S. Bandoh, T. Tsukada, K. Maruyama, N. Ohkura, K. Yamaguchi, Differential expression of NGFI-B and RNR-1 genes in various tissues and developing brain of the rat: comparative study by quantitative reverse transcription-polymerase chain reaction, J. Neuroendocrinol. 9 (1997) 3-8.
18. O. Saucedo-Cardenas, R. Kardon, T.R. Ediger, J.P. Lydon, O.M. Conneely, Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1, Gene 187 (1997) 135-139.
19. C. Chang, A. Saltzman, H.J. Lee, H. Uemura, G. Chodak, T. Kakamoto, M. LeBeau, R.S. Lemens, L. Sivak, C. Shih, Genomic structure, chromosomal localization and expression of an androgen inducible TR3 orphan receptor: a member of the steroid receptor superfamily, Endocr. J. 1 (1993) 541-549.
20. N. Ohkura, M. Ito, T. Tsukada, K. Sasaki, K. Yamaguchi, K. Miki, Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA, Gene 211 (1998) 79-85.
21. Y. Katagiri, Y. Hirata, J. Milbrandt, G. Guroff, Differential regulation of the transcriptional activity of the orphan nuclear receptor NGFI-B by membranedepolarization and nerve growth factor, J. Biol. Chem. 272 (1997) 31278-31284.
22. G.P. Bondy, Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR77/NGFI-B genes, Cell Growth Differ. 2 (1991) 203-208.
23. R.H. Zetterström, L. Solomin, T. Mitsiadis, L. Olson, T. Perlmann, Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1, Mol. Endocrinol. 10 (1996) 1656-1666.
24. N. Ohkura, M. Ito, T. Tsukada, K. Sasaki, K. Yamaguchi, K. Miki, Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family, Biochim. Biophys. Acta 1308 (1996) 205-214.
25. P. Chomczynski, N. Sacchi, Single-step method of RNA isolation by acidguanidinium thiocyanate-Phenol-chloroform extraction, Anal. Biochem. 162 (1987) 156-159.
26. K. Maruyama, T. Tsukada, S. Bandoh, K. Sasaki, N. Ohkura, K. Yamaguchi, Expression of NOR-1 and its closely related members of the steroid/thyroid hormone receptor superfamily in human neuroblastoma cell lines, Cancer Lett. 96 (1995) 117-122.
27. E.P. Murphy, A.D. Dobson, C. Keller, O.M. Conneely, Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors, Gene Express. 5 (1996) 169-179.
28. A. Philips, S. Lesage, R. Gingras, M.-H. Maira, Y. Gauthier, P. Hugo, J. Drouin, Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells, Mol. Cell. Biol. 17 (1997) 5946-5951.
29. Q. Wu, Y. Li, R. Liu, A. Agadir, M.-O. Lee, Y. Liu, X. Zhang, Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization, EMBO J. 16 (1997) 1656-1669.
30. I. Petropoulos, D. Part, A. Ochoa, M.M. Zakin, E. Lamas, NOR-2 (neuron-derived orphan receptor), a brain zinc protein, is highly induced during liver regeneration, FEBS Lett. 372 (1995) 273-278.