Allene as an alternative functional group for drug design: Effect of C-C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase

ChemMedChem

Volumn 3, Issue 7, 2008, Pages 1094-1103

  Ban, Hyun Seung ^a   Onagi, Shinya ^a   Uno, Masaharu ^a   Nabeyama, Wataru ^a   Nakamura, Hiroyuki ^a  

^a GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

Allenes; Anticancer agents; EGFR; Quinazolines; Tyrosine kinase inhibitors

Indexed keywords

ALKADIENE; EPIDERMAL GROWTH FACTOR RECEPTOR; PALLADIUM; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CATALYSIS; CELL CYCLE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; HUMAN; PHOSPHORYLATION; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALKADIENES; APOPTOSIS; CATALYSIS; CELL CYCLE; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; PALLADIUM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54849203000     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800073     Document Type: Article

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