β-Phenylethylamine inhibits K+ currents in neocortical neurons of the rat: A possible mechanism of β-phenylethylamine-induced seizures

Tohoku Journal of Experimental Medicine

Volumn 215, Issue 4, 2008, Pages 333-340

  Kitamura, Taro ^a   Munakata, Mitsutoshi ^a   Haginoya, Kazuhiro ^a   Tsuchiya, Shigeru ^a   Iinuma, Kazuie ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

phenylethylamine; M current; Patch clamp; Seizure

Indexed keywords

EID: 54749129973     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.215.333     Document Type: Article

References (26)

1. Akaike, N. & Harata, N. (1994) Nystatin perforated path recording and its applications to analyses of intracellular mechanisms. Jpn. J. Physiol., 44, 433-473.
2. Bergman, J., Yasar, S. & Winger, G. (2001) Psychomotor stimulant effects of β-phenylethylamine in monkeys treated with MAO-B inhibitors. Psychopharmacology (Berl), 159, 21-30.
3. Borowsky, B., Adham, N., Jones, K.A., Raddatz, R., Artymyshy, R., Ogozalek, K.L., Durkin, M.M., Lakhlani, P.P., Bonini, J.A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F.Y., Branchek, T.A. & Gerald, C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. USA, 98, 8966-8971.
4. Branchek, T.A. & Blackburn, T.P. (2003) Trace amine receptors as targets for novel therapeutics: legend myth and fact. Curr. Opin. Pharmacol., 3, 90-97.
5. + current in a vertebrate neurone. Nature, 283, 673-676.
6. + channel blockers. J. Med. Chem., 45, 3844-3853.
7. Cooper, E.C. & Jan, L.Y. (2003) M-channels: neurological diseases, neuromodulation, and drug development. Arch. Neurol., 60, 496-500.
8. Dourish, C.T. (1981) Behavioural effects of acute and chronic β-phenylethylamine administration in the rat: evidence for the involvement of 5-hydroxytryptamine. Neuropharmacology, 20, 1067-1072.
9. Dourish, C.T. & Cooper, S.J. (1983) Pharmacology of β-phenylethylamine-induced seizures in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry, 7, 787-790.
10. Elsworth, J.D., Glover, V., Reynolds, G.P., Sandler, M., Lees, A.J., Phuapradit, P., Shaw, K.M.. Stern, G.M. & Kumar, P. (1978) Deprenyl administration in man: a selective monoamine oxidase B inhibitor without the 'cheese effect'. Psychopharmacology (Berl.), 57, 33-38.
11. B response in dopaminergic neurons by inhibiting G-βγ-gated inwardly rectifying potassium channels. Mol. Pharmacol., 67, 1283-1290.
12. Fernandez, D., Ghanta, A., Kauffman, G.W. & Sanguinetti, M.C. (2004) Physicochemical features of the hERG channel drug binding site. J. Biol. Chem., 279, 10120-10127.
13. Fuller, R.W., Snoddy, H.D., Molloy, B.B. & Hauser, K.M. (1973) CNS stimulant properties and physiologic disposition of β, β-difluorophenylethylamine in mice. Psychopharmacologia, 28, 205-212.
14. Henry, D.P., Russell, J.A., Clemens, J.A. & Plebus, L.A. (1988) Phenylethylamine and p-tyramine in the extracellular space of the rat brain: quantification using a new radioenzymatic assay and in situ microdialysis. In: Trace amines: comparative and clinical neurobiology, edited by A.A. Boulton, A.V. Juorio & R.G.H. Downer. Humana Press, Clifton, NJ, pp. 239-250.
15. Janssen, P.A., Leysen, J.E., Megens, A.A. & Awouters, F.H. (1999) Does phenylethylamine act as an endogenous amphetamine in some patients? Int. J. Neuropsychopharmacol., 2, 229-240.
16. Lapin, I.P. (1990) Beta-phenylethylamine (PEA): an endogenous anxiogen? Three series of experimental data. Biol. Psychiatry, 28, 997-1003.
17. Lindemann. L., Ebeling, M., Kratochwil, N.A., Bunzow, J.R., Grandy, D.K. & Hoener, M.C. (2005) Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics, 85, 372-385.
18. Lindemann, L., Meyer, C.A., Jeanneau, K., Bradaia, A., Ozmen, L., Bluethmann, H., Bettler, B., Wettstein, J.G., Borroni, E., Moreau, J.L. & Hoener, M.C. (2008) Trace amine-associated receptor 1 modulates dopaminergic activity. J. Pharmacol. Exp. Ther., 324, 948-956.
19. Munakata, M. & Akaike, N. (1993) Theophylline affects three different potassium currents in dissociated rat cortical neurons. J. Physiol., 471, 599-616.
20. 2 receptors in neurons dissociated from rat neostriatum. J. Physiol., 480, 233-245.
21. Murase, K., Ryu, P.D. & Randic, M. (1989) Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons. Neurosci. Lett., 103, 56-63.
22. Paterson. I.A., Juorio, A.V. & Boulton, A.A. (1990) 2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system? J. Neurochem., 55, 1827-1837.
23. 1 antagonists block M-currents in dissociated rat cortical neurons. Brain Res., 1057, 81-87.
24. 2]-Met-enkephalinamide-induced seizures. Naunyn-Schmiedeberg's Arch. Pharmacol., 322, 38-41.
25. Xie, Z. & Miller, G.M. (2007) Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J. Pharmacol. Exp. Ther., 321, 128-136.
26. Xie, Z. & Miller, G.M. (2008) β-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J. Pharmacol. Exp. Ther. 2008, 325, 617-628.