Protective effects of melatonin against formaldehyde-induced oxidative damage and apoptosis in rat testes: An immunohistochemical and biochemical study

Systems Biology in Reproductive Medicine

Volumn 54, Issue 4-5, 2008, Pages 169-176

  Ozen, Oguz Aslan ^a,c   Kus, Murat A ^a   Kus, Ilter ^b   Alkoc, Ozan Alper ^a   Songur, Ahmet ^a  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

^b FIRAT UNIVERSITY   (Turkey)

^c NAMIK KEMAL UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Formaldehyde; Melatonin; Oxidative damage; Testes

Indexed keywords

FORMALDEHYDE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MELATONIN; PROTEIN BAX; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEYDIG CELL; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; TESTIS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FORMALDEHYDE; GLUTATHIONE PEROXIDASE; LEYDIG CELLS; MALE; MALONDIALDEHYDE; MELATONIN; OXIDATIVE STRESS; RATS; SPERMATOCYTES; SPERMATOGENESIS; SUPEROXIDE DISMUTASE; TESTIS;

EID: 54549092696     PISSN: 19396368     EISSN: 19396368     Source Type: Journal    
DOI: 10.1080/19396360802422402     Document Type: Article

References (60)

1. Arslan, S. O., Zerin, M., Vural, H. and Coskun, A. (2002) The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. J Pineal Res 32:21-25.
2. Ayar, A., Kutlu, S., Yilmaz, B. and Kelestimur, H. (2001) Melatonin inhibits spontaneous and oxytocin-induced contractions of rat myometrium in vitro. Neuroendocrinol Lett 22:301-306.
3. Chang, J. C. F., Gross, E. A., Swenberg, J. A. and Barrow, C. S. (1983) Nasal cavity deposition, histopathology and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats. Toxicol Appl Pharmacol 68:161-176.
4. Cheng, G., Shi, Y., Sturla, S. J., Jalas, J. R., Mclntee, E. J., Villalta, P. W., Wang, M. and Hecht, S. S. (2003) Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: Formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chem Res Toxicol 16:145-152.
5. Chohen, B. I., Pagnillo, M. K., Musikant, B. L. and Deutsch, A. S. (1998) Formaldehyde evaluation from endodontic materials. Oral Health 88:37-39.
6. Chowdhury, A. R., Gautam, A. K., Patel, K. G. and Trivedi, H. S. (1992) Steroidogenic inhibition in testicular tissue of formaldehyde exposed rats. Indian J Physiol Pharmacol 36:162-168.
7. Collins, J. J., Ness, R., Tyl, R. W., Krivanek, N., Esmen, N. A. and Hall, T. A. (2001) A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies. Regul Toxicol Pharmacol 34:17-34.
8. Costa, E. J. X., Lopez, R. H. and Lamy-Freund, M. T. (1995) Permeability of pure lipid bilayers to melatonin. J Pineal Res 19:123-126.
9. Debatin, K. M. (2004) Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 53:153-159.
10. Erol, F. S., Topsakal, C., Ozveren, M. F., Kaplan, M., Ilhan, N., Ozercan, I. H. and Yildiz, O. G. (2004) Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: An experimental study. Neurosurg Rev 27:65-69.
11. Esterbauer, H. and Cheeseman, K. H. (1990) Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186:407-421.
12. Feron, V. J., Bruyntjes, J. P., Woutersen, R. A., Immel, H. R. and Appelman, L. M. (1988) Nasal tumors in rats after short-term exposure to a cyto-toxic concentration of formaldehyde. Cancer Lett 39:101-110.
13. Forsling, M. L., Stoughton, R. P., Zhou, Y., Kelestimur, H. and Demaine, C. (1993) The role of the pineal in the control of the daily patterns of neurohypophysial hormone secretion. J Pineal Res 14:45-51.
14. Franklin, P., Dingle, P. and Stick, S. (2000) Raised exhaled nitric oxide in healthy children is associated with domestic formaldehyde levels. Am J Respir Crit Care Med 161:1757-1759.
15. Guerrero, J. M. and Reiter, R. J. (1992) A brief survey of pineal gland-immune system interrelationships. Endocr Res 18:91-113.
16. Gurel, A., Coskun, O., Armutcu, F., Kanter, M. and Ozen, O. A. (2005) Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: Biochemical and histological studies. J Chem Neuroanat 29:173-178.
17. Halperin, W. E., Goodman, M., Stayner, L., Elliot, L. J., Keenlyside, R. A. and Landrigan, P. J. (1983) Nasal cancer in a worker exposed to formaldehyde. JAMA 249:510-516.
18. Juknat, A. A., Mendez Mdel, V., Quaglino, A., Fameli, C. I., Mena, M. and Kotler, M. L. (2005) Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes. J Pineal Res 38:84-92.
19. Kabuto, H., Yokoi, I. and Ogawa, N. (1998) Melatonin inhibits iron-induced epileptic discharges in rats by suppressing peroxidation. Epilepsia 39:237-243.
20. Kamal, A. A., Gomaa, A., El Khafif, M. and Hammad, A. S. (1989) Plasma lipid peroxides among workers exposed to silica or asbestos dust. Environ Res 49:173-180.
21. Kilburn, K. H., Warshaw, R. and Thornton, J. C. (1987) Formaldehyde impairs memory, equilibrium, and dexterity in histology technicians: Effects which persist for days after exposure. Arch Environ Health 42:117-120.
22. Kus, I., Ogeturk, M., Oner, H., Sahin, S., Yekeler, H. and Sarsilmaz, M. (2005) Protective effects of melatonin against carbon tetrachlorideinduced hepatotoxicity in rats: A light microscopic and biochemical study. Cell Biochem Funct 23:169-174.
23. Longoni, B., Salgo, M. G., Pryor, W. A. and Marchiafava, P. L. (1998) Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sci 62:853-859.
24. Lu, J., Moochhala, S., Kaur, C. and Ling, E. A. (2000) Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury. Neurosci Lett 290:89-92.
25. Majumder, P. K. and Kumar, V. L. (1995) Inhibitory effects of formaldehyde on the reproductive system of male rats. Indian J Physiol Pharmacol 39:80-82.
26. Mayo, J. C., Sainz, R. M., Uria, H., Antolin, I., Esteban, M. M. and Rodriguez, C. (1998) Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: Implications for Parkinson's disease. J Pineal Res 24:179-192.
27. Menendez-Pelaez, A., Poeggeler, B., Reiter, R. J., Barlow- Walden, L., Pablos, M. I. and Tan, D. X. (1993) Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence. J Cell Biochem 53:373-382.
28. Metz, B., Kersten, G. F., Hoogerhout, P., Brugghe, H. F., Timmermans, H. A., de Jong, A., Meiring, H., ten Hove, J., Hennink, W. E., Crommelin, D. J. and Jiskoot, W. (2004) Identification of formaldehyde-induced modifications in proteins: Reactions with model peptides. J Biol Chem 279:6235-6243.
29. Monteiro Riviere, N. A. and Popp, J. A. (1986) Ultrastructural evaluation of acute nasal toxicity in the rat respiratory epitelium in response to formaldehyde gas. Fundam Appl Toxicol 6:251-262.
30. Morgan, K. T., Patterson, D. L. and Gross, E. A. (1986) Responses of the nasal mucocliary apparatus of F-344 rats to formaldehyde gas. Toxicol Appl Pharmacol 82:1-13.
31. Nagata, S. (1997) Apoptosis by death factor. Cell 88:355-365.
32. Ogeturk, M., Kus, I., Kavakli, A., Oner, J., Kukner, A. and Sarsilmaz, M. (2005) Reduction of carbon tetrachloride-induced nephropathy by melatonin administration. Cell Biochem Funct 23:85-92.
33. Okatani, Y., Okamoto, K., Hayashi, K., Wakatsuki, A., Tamura, S. and Sogara, Y. (1998) Maternal-fetal transfer of melatonin in pregnant women near term. J Pineal Res 25:129-134.
34. Ozen, O. A., Akpolat, N., Songur, A., Kus, I., Zararsiz, I., Ozacmak, V. H. and Sarsilmaz, M. (2005) Effect of formaldehyde inhalation on Hsp70 in seminiferous tubules of rat testes: An immunohistochemical study. Toxicol Ind Health 21:249-254.
35. Ozen, O. A., Songur, A., Sarsilmaz, M., Yaman, M. and Kus, I. (2003) Zinc, copper and iron concentrations in cerebral cortex of male rats exposed to formaldehyde inhalation. J Trace Elem Med Biol 17:207-209.
36. Paglia, D. E. and Valentine, W. N. (1967) Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169.
37. Pedreanez, A., Rincon, J., Romero, M., Viera, N. and Mosquera, J. (2004) Melatonin decreases apoptosis and expression of apoptosis-associated proteins in acute puromycin aminonucleoside nephrosis. Nephrol Dial Transplant 19:1098-1105.
38. Pradip, K. M. and Vijay, L. K. (1995) Inhibitory effects of formaldehyde on the reproductive system of male rats. Indian J Physiol Pharmacol 39:80-82.
39. Reiter, R. J., Carneiro, R. C. and Oh, C. S. (1997) Melatonin in relation to cellular antioxidative defense mechanisms. Horm Metab Res 29:363-372.
40. Sener, G., Sehirli, A. O. and Ayanoglu-Dulger, G. (2003) Melatonin protects against mercury (II)-induced oxidative tissue damage in rats. Pharmacol Toxicol 93:290-296.
41. Sewerynek, E., Melchiorri, D. A., Chen, L. and Reiter, R. J. (1995) Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro. Free Radic Biol Med 19:903-909.
42. Shida, C. S., Castrucci, A. M. L. and Lamy-Freund, M. T. (1994) High melatonin solubility in aqueous medium. J Pineal Res 16:198-201.
43. Simith, A. E. (1992) Formaldehyde. Occup Med 42:83-88.
44. Songur, A., Akpolat, N., Kus, I., Ozen, O. A., Zararsiz, I. and Sarsilmaz, M. (2003) The effects of the inhaled formaldehyde during the early postnatal period in the hippocampus of rats: A morphological and immunohistochemical study. Neurosci Res Commun 33:168-178.
45. Stastica, P., Ulanski, P. and Rosiak, J. M. (1998) Melatonin as a hydroxyl radical scavenger. J Pineal Res 25:65-66.
46. Sun, Y., Oberley, L. W. and Li, Y. (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497-500.
47. Tan, D. X., Manchester, L. C., Reiter, R. J., Qi, W., Kim, S. J. and El-Sokkary, G. H. (1998) Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice. J Neurosci Res 54:382-389.
48. Tang, M., Xie, Y., Yi, Y. and Wang, W. (2003) Effects of formaldehyde on germ cells of male mice. Wei Sheng Yan Jiu 32:544-548.
49. Tang, X. L., Qiu, Y., Turrens, J. F., Sun, J. Z. and Bolli, R. (1997) Late preconditioning against stunning is not mediated by increased antioxidant defenses in conscious pigs. Am J Physiol 273:1651-1657.
50. Taskinen, H., Kyyronen, P., Hemminki, K., Hoikkala, M., Lajunen, K. and Lindbohm, M. L. (1994) Laboratory work and pregnancy outcome. J Occup Med 36:311-319.
51. Thrasher, J. D. and Kilburn, K. H. (2001) Embryo toxicity and teratogenicity of formaldehyde. Arch Environ Health 56:300-311.
52. Topal, T., Oter, S., Korkmaz, A., Sadir, S., Metinyurt, G., Korkmazhan, E. T., Serdar, M. A., Bilgic, H. and Reiter, R. J. (2004) Exogenously administered and endogenously produced melatonin reduce hyperbaric oxygen-induced oxidative stress in rat lung. Life Sci 75:461-467.
53. Usanmaz, S. E., Akarsu, E. S. and Vural, N. (2002) Neurotoxic effects of acute and subacute formaldehyde exposures in mice. Envir Toxicol Pharmacol 11:93-100.
54. Walker, N. I., Harmon, B. V., Gobe, G. C. and Kerr, J. F. (1988) Pattern of cell death. Methods Achiev Exp Pathol 13:18-54.
55. Yoo, Y. M., Yim, S. V., Kim, S. S., Jang, H. Y., Lea, H. Z., Hwang, G. C., Kim, J.W., Kim, S. A., Lee, H. J., Kim, C. J., Chung, J. H. and Leem, K. H. (2002) Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells. J Pineal Res 33:146-150.
56. Zang, L. Y., Cosma, G., Gardner, H. and Vallyathan, V. (1998) Scavenging of reactive oxygen species by melatonin. Biochim Biophys Acta 1425:469-477.
57. Zararsiz, I., Kus, I., Ogeturk, M., Akpolat, N., Kose, E., Meydan, S. and Sarsilmaz, M. (2007) Melatonin prevents formaldehyde-induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study. Cell Biochem Funct 25:413-418.
58. Zararsiz, I., Kus, I., Akpolat, N., Songur, A., Ogeturk, M. and Sarsilmaz, M. (2006a) Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats. Cell Biochem Funct 24:237-244.
59. Zararsiz, I., Sonmez, M. F., Yilmaz, H. R., Tas, U., Kus, I., Kavakli, A. and Sarsilmaz, M. (2006b) Effects of o-3 essential fatty acids against formaldehyde-induced nephropathy in rats. Toxicol Ind Health 22:223-229.
60. Zhou, D. X., Qui, S. D., Zhang, J., Tian, H. and Wang, H. X. (2006) The protective effect of vitamin E against oxidative damage caused by formaldehyde in the testes of adult rats. Asian J Androl 8:584-588.