Effect of formaldehyde inhalation on Hsp70 in seminiferous tubules of rat testes: An immunohistochemical study

Toxicology and Industrial Health

Volumn 21, Issue 9, 2005, Pages 249-254

  Özen, Oğuz Aslan ^a   Akpolat, Nusret ^b   Songur, Ahmet ^a   Kuş, İlter ^a   Zararsiz, İsmail ^a   Özaçmak, Veysel Haktan ^c   Sarsilmaz, Mustafa ^a  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

^b FIRAT UNIVERSITY   (Turkey)

^c ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

Author keywords

formaldehyde exposure; Hsp70; inhalation; seminiferous tubule; testis

Indexed keywords

EOSIN; FORMALDEHYDE; HEAT SHOCK PROTEIN 70; HEMATOXYLIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CHEMOLUMINESCENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENZYME IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LONG TERM EXPOSURE; MALE; NONHUMAN; PROTEIN SYNTHESIS; RAT; SEMINIFEROUS TUBULE; SPERMATID; SPERMATOCYTE; SPERMATOGONIUM; STRESS; TESTIS; TESTOSTERONE BLOOD LEVEL;

ANIMALS; FORMALDEHYDE; HSP70 HEAT-SHOCK PROTEINS; IMMUNOENZYME TECHNIQUES; INHALATION EXPOSURE; MALE; RATS; RATS, WISTAR; SEMINIFEROUS TUBULES; TESTOSTERONE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 30644461754     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233705th235oa     Document Type: Article

References (15)

1. Auerbach, C. 1977: Genetic and cytogenetical effects of formaldehyde and related compounds. Mutation Research 39, 317-362.
2. Chang, J. C., Steinhagen, W. H. and Barrow, C. S. 1981: Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F-344 rats. Toxicology and Applied Pharmacology 61, 451-459.
3. Chang, J. C. F., Gross, E. A., Swenberg, J. A. and Barrow, C. S. 1983: Nasal cavity deposition, histopathology, and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats. Toxicology and Applied Pharmacology 68, 161-176.
4. Chowdhury, A. R., Gautam, A. K., Patel, K. G. and Trivedi, H. S. 1992: Steroidogenic inhibition in testicular tissue of formaldehyde exposed rats. Indian Journal of Physiology and Pharmacology 36, 162-168.
5. Collins, J. J., Ness, R., Tyl, R. W. et al. 2001: A review of adverse pregnancy outcomes and formaldehyde exposure in human and animal studies. Regulatory Toxicology and Pharmacology 34, 17-34.
6. Craig, E. A. 1985: The heat shock response. CRC Critical Reviews in Biochemistry 18, 239-280.
7. Dix, D. J., Allen, J. W., Collins, B. W. et al. 1996: Targeted gene disruption of hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Developmental Biology 93, 3264-3268.
8. Dix, D. J., Allen, J. W., Collins, B. W. et al. 1997: HSP70-2 is required for desynapsis of synaptonemal complexes during meiotic prophase in juvenile and adult mouse spermatocytes. Development 124, 4595-4603.
9. Feron, V. J., Bruyntjes, J. P., Wouterson, R. A. et al. 1988: Nasal tumors in rats after short-term exposure to a cytotoxic concentration of formaldehyde. Cancer Letters 39, 101-110.
10. Georgopoulos, C. and Welch, W. J. 1993: Role of the major heat shock proteins as molecular chaperones. Annual Review of Cell Biology 9, 601-634.
11. Heck, H., Casanova, M. and Starr, T. B. 1990: Formaldehyde toxicity: new understanding. Critical Reviews in Toxicology 6, 397-426.
12. Özen, O.A. 2001: The investigation of the effect of inhaled formaldehyde on the rat testicular tissue morphologically, (Doctoral thesis). Firat University, Institute of Health Sciences, Elazig’, Turkey, 1-80 (in Turkish).
13. Pradip, K. M. and Vijay, L. K. 1995: Inhibitory effects of formaldehyde on the reproductive system of male rats. Indian Journal of Physiology and Pharmacology 39, 80-82.
14. Tytell, M. and Barbe, M. F. 1987: Synthesis and axonal transport of heat shock proteins. In Smith, R. S. and Bisby, M. A., editors, Axonal transport. New York, NY: Alan R. Liss, 473-492.
15. Yilmaz, B., Kutlu, S., Canpolat, S. et al. 2001: Effects of paint thinner exposure on serum LH, FSH and testosterone levels and hypothalamic catecholamine contents in the male rat. Biological and Pharmaceutical Bulletin 24(2), 163-166.