Resistance to human immunodeficiency virus type 1 (HIV-1) generated by lentivirus vector-mediated delivery of the CCR5Δ32 gene despite detectable expression of the HIV-1 co-receptors

Journal of General Virology

Volumn 89, Issue 10, 2008, Pages 2611-2621

  Jin, Qingwen ^a,c   Marsh, Jon ^b   Cornetta, Kenneth ^a,b   Alkhatib, Ghalib ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; LENTIVIRUS VECTOR; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL BASED GENE THERAPY; CELL IMMORTALIZATION; CELL SURFACE; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 1; INFECTION RESISTANCE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; VIRAL GENE DELIVERY SYSTEM; VIRUS INHIBITION; VIRUS MUTANT; VIRUS RECOMBINANT; WILD TYPE; CELL LINE; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HELA CELL; LENTIVIRINAE; METABOLISM; MONONUCLEAR CELL; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRUS CELL TRANSFORMATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1; LENTIVIRUS;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; GENE PRODUCTS, ENV; GENETIC VECTORS; HELA CELLS; HIV-1; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LENTIVIRUS; LEUKOCYTES, MONONUCLEAR; RECEPTORS, CCR5; TRANSDUCTION, GENETIC;

EID: 54449101305     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.2008/003624-0     Document Type: Article

References (44)

1. + cells. J Virol 78, 2277-2287.
2. Agrawal, L., Jin, Q., Altenburg, J., Meyer, L., Tubiana, R., Theodorou, I. & Alkhatib, G. (2007). CCR5Δ32 protein expression and stability are critical for resistance to human immunodeficiency virus type 1 in vivo. J Virol 81, 8041-8049.
3. Alkhatib, G. & Berger, E. A. (2007). HIV coreceptors: from discovery and designation to new paradigms and promise. Eur J Med Res 12, 375-384.
4. Alkhatib, G., Combadiere, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M. & Berger, E. A. (1996). CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958.
5. Alkhatib, G., Liao, F., Berger, E. A., Farber, J. M. & Peden, K. W. (1997). A new SIV co-receptor, STRL33. Nature 388, 238.
6. Barry, S. C., Harder, B., Brzezinski, M., Flint, L. Y., Seppen, J. & Osborne, W. R. (2001). Lentivirus vectors encoding both central polypurine tract and posttranscriptional regulatory element provide enhanced transduction and transgene expression. Hum Gene Ther 12, 1103-1108.
7. Benkirane, M., Jin, D. Y., Chun, R. F., Koup, R. A. & Jeang, K. T. (1997). Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32. J Biol Chem 272, 30603-30606.
8. Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A. & Mackay, C. R. (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A 94, 1925-1930.
9. Braciak, T. A., Bacon, K., Xing, Z., Torry, D. J., Graham, F. L., Schall, T. J., Richards, C. D., Croitoru, K. & Gauldie, J. (1996). Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung. J Immunol 157, 5076-5084.
10. + T-cell lines vs. primary macrophages. Proc Natl Acad Sci U S A 92, 9004-9008.
11. Broder, C. C. & Earl, P. L. (1999). Recombinant vaccinia viruses. Design, generation, and isolation. Mol Biotechnol 13, 223-245.
12. Broxmeyer, H. E., Srour, E., Orschell, C., Ingram, D. A., Cooper, S., Plett, P. A., Mead, L. E. & Yoder, M. C. (2006). Cord blood stem and progenitor cells. Methods Enzymol 419, 439-473.
13. Chelli, M. & Alizon, M. (2001). Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor. J Biol Chem 276, 46975-46982.
14. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., Wu, L., Mackay, C. R., LaRosa, G. & other authors (1996). The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85, 1135-1148.
15. + lymphocyte transformation and infection in a rabbit model with a molecular clone of human T-cell lymphotrophic virus type 1. J Virol 70, 7241-7246.
16. Dean, M., Carrington, M., Winkler, C., Huttley, G. A., Smith, M. W., Allikmets, R., Goedert, J. J., Buchbinder, S. P., Vittinghoff, E. & other authors (1996). Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273, 1856-1862.
17. Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E. & other authors (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
18. Doranz, B. J., Rucker, J., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G. & Doms, R. W. (1996). A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85, 1149-1158.
19. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667-673.
20. Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D. & Naldini, L. (1998). A third-generation lentivirus vector with a conditional packaging system. J Virol 72, 8463-8471.
21. Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872-877.
22. Hladik, F., Liu, H., Speelmon, E., Livingston-Rosanoff, D., Wilson, S., Sakchalathorn, P., Hwangbo, Y., Greene, B., Zhu, T. & McElrath, M. J. (2005). Combined effect of CCR5-Δ32 heterozygosity and the CCR5 promoter polymorphism 22459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol 79, 11677-11684.
23. Kabat, D., Kozak, S. L., Wehrly, K. & Chesebro, B. (1994). Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1. J Virol 68, 2570-2577.
24. Ketas, T. J., Kuhmann, S. E., Palmer, A., Zurita, J., He, W., Ahuja, S. K., Klasse, P. J. & Moore, J. P. (2007). Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands. Virology 364, 281-290.
25. Kuhmann, S. E., Platt, E. J., Kozak, S. L. & Kabat, D. (2000). Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1. J Virol 74, 7005-7015.
26. Lee, B., Sharron, M., Montaner, L. J., Weissman, D. & Doms, R. W. (1999). Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci U S A 96, 5215-5220.
27. Markham, P. D., Salahuddin, S. Z., Kalyanaraman, V. S., Popovic, M., Sarin, P. & Gallo, R. C. (1983). Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T-cell leukemia-lymphoma virus (HTLV). Int J Cancer 31, 413-420.
28. Mellado, M., Serrano, A., Martínez, C. & Rodríguez-Frade, J. M. (2006). G protein-coupled receptor dimerization and signaling. Methods Mol Biol 332, 141-157.
29. Meyer, L., Magierowska, M., Hubert, J. B., Rouzioux, C., Deveau, C., Sanson, F., Debre, P., Delfraissy, J. F., Theodorou, I. & The SEROCO Study Group (1997). Early protective effect of CCR-5Δ32 heterozygosity on HIV-1 disease progression: relationship with viral load. AIDS 11, F73-F78.
30. Miyoshi, I., Kubonishi, I., Yoshimoto, S., Akagi, T., Ohtsuki, Y., Shiraishi, Y., Nagata, K. & Hinuma, Y. (1981). Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature 294, 770-771.
31. Nussbaum, O., Broder, C. C. & Berger, E. A. (1994). Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation. J Virol 68, 5411-5422.
32. O'Brien, S. J. & Moore, J. P. (2000). The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol Rev 177, 99-111.
33. Pello, O. M., Martínez-Mu-tinnoz, L., Parrillas, V., Serrano, A., Rodríguez-Frade, J. M., Toro, M. J., Lucas, P., Monterrubio, M., Martínez, A. C. & Mellado, M. (2008). Ligand stabilization of CXCR4/δ-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur J Immunol 38, 537-549.
34. Popovic, M., Lange-Wantzin, G., Sarin, P. S., Mann, D. & Gallo, R. C. (1983). Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sci U S A 80, 5402-5406.
35. Rodríguez-Frade, J. M., del Real, G., Serrano, A., Hernanz-Falcón, P., Soriano, S. F., Vila-Coro, A. J., de Ana, A. M., Lucas, P., Prieto, I. & other authors (2004). Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor. EMBO J 23, 66-76.
36. Sohy, D., Parmentier, M. & Springael, J. Y. (2007). Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem 282, 30062-30069.
37. + T cell depletion in humanized mice infected with HIV-1. J Exp Med 204, 705-714.
38. Swan, C. H. & Torbett, B. E. (2006). Can gene delivery close the door to HIV-1 entry after escape? J Med Primatol 35, 236-247.
39. Theodorou, I., Meyer, L., Magierowska, M., Katlama, C. & Rouzioux, C. (1997). HIV-1 infection in an individual homozygous for CCR5D32. Lancet 349, 1219-1220.
40. Venkatesan, S., Petrovic, A., Van Ryk, D. I., Locati, M., Weissman, D. & Murphy, P. M. (2002). Reduced cell surface expression of CCR5 in CCR5Δ32 heterozygotes is mediated by gene dosage, rather than by receptor sequestration. J Biol Chem 277, 2287-2301.
41. Wolkowicz, R. & Nolan, G. P. (2005). Gene therapy progress and prospects: novel gene therapy approaches for AIDS. Gene Ther 12, 467-476.
42. Xiao, X., Kinter, A., Broder, C. C. & Dimitrov, D. S. (2000). Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells. Exp Mol Pathol 68, 133-138.
43. Yamamoto, N., Okada, M., Koyanagi, Y., Kannagi, M. & Hinuma, Y. (1982). Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line. Science 217, 737-739.
44. Zimmerman, P. A., Buckler-White, A., Alkhatib, G., Spalding, T., Kubofcik, J., Combadiere, C., Weissman, D., Cohen, O., Rubbert, A. & other authors (1997). Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 3, 23-36.