Short and long-term effects of hVEGF-A165 in cre-activated transgenic mice

PLoS ONE

Volumn 1, Issue 1, 2006, Pages

  Leppänen, Pia ^a   Kholová, Ivana ^a   Mähönen, Anssi J ^a   Airenne, Kari ^a   Koota, Suvi ^a   Mansukoski, Hannu ^b   Närväinen, Johanna ^c   Wirzenius, Maria ^d   Alhonen, Leena ^a   Jänne, Juhani ^a   Alitalo, Kari ^d   Ylä Herttuala, Seppo ^a,e  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF HELSINKI   (Finland)

^e KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CRE RECOMBINASE; GROWTH FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A165; PRIMER DNA; RECOMBINANT PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; CONTROLLED STUDY; GENE CASSETTE; GENE OVEREXPRESSION; GENE TRANSFER; LIVER; LIVER CELL CARCINOMA; LIVER HEMANGIOMA; LOXP SITE; LUNG ADENOCARCINOMA; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN DISEASE; TRANSGENIC MOUSE; ADENOVIRUS; ANIMAL; BAGG ALBINO MOUSE; DBA MOUSE; FEMALE; GENE EXPRESSION; GENE VECTOR; GENETICS; HUMAN; LIVER TUMOR; LUNG TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUCLEOTIDE SEQUENCE; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; TIME; VASCULARIZATION;

ADENOVIRIDAE; MUS; MUS MUSCULUS;

ADENOVIRIDAE; ANIMALS; BASE SEQUENCE; DNA PRIMERS; FEMALE; GENE EXPRESSION; GENETIC VECTORS; HUMANS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; PHENOTYPE; RECOMBINANT PROTEINS; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 54449091655     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000013     Document Type: Article

References (36)

1. Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG (1991) Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 88: 9267-9271.
2. Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo KA (1996) Novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 15: 290-298.
3. Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676.
4. Ylä -Herttuala S, Alitalo K (2003) Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 9: 694-701.
5. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea, et al. (1996) Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439-442.
6. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439.
7. Gerber H, Hillan KJ, Ryan AM, Kowalski J, Keller G, et al. (1999) Vegf is required for growth and survival in neonatal mice. Development 126: 1149-1159.
8. Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med 5: 495-502.
9. Kärkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, et al. (2001) Model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci USA 98: 12677-12682.
10. Kärkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, et al. (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5: 74-80.
11. Bellomo D, Headrick JP, Silins GU, Paterson CA, Thomas PS, et al. (2000) Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res 86: E29-35.
12. Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, et al. (2001) Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-583.
13. Baldwin ME, Halford MM, Roufail S, Williams RA, Hibbs ML, et al. (2005) Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol 25: 2441-2449.
14. Vogel J, Gehrig M, Kuschinsky W, Marti HH (2004) Massive inborn angiogenesis in the brain scarcely raises cerebral blood flow. J Cereb Blood Flow Metab 24: 849-859.
15. Detmar M, Brown LF, Schon MP, Elicker BM, Velasco P, et al. (1998) Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice J Invest Dermatol 111: 1-6.
16. Zeng X, Wert SE, Federici R, Peters KG, Whitsett JA (1998) VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Dev Dyn 211: 215-227.
17. Okamoto N, Tobe T, Hackett SF, Ozaki H, Vinores MA, LaRochelle, et al. (1997) Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization Am J Pathol 151: 281-291.
18. Dor Y, Djonov V, Abramovitch R, Itin A, Fishman GI, et al. (2002) Conditional switching of VEGF provides new insights into adult neovascularization and proangiogenic therapy. EMBO J 21: 1939-1947.
19. Odorisio T, Schietroma C, Zaccaria ML, Cianfarani F, Tiveron C, et al. (2002) Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. J Cell Sci 115: 2559-2567.
20. Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, et al. (1997) Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276: 1423-1425.
21. Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, et al. (2001) Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J 20: 1223-1231.
22. Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, et al. (2001) Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 20: 672-682.
23. Laitinen M, Mäkinen K, Manninen H, Matsi P, Kossila M, et al. (1998) Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. Hum Gene Ther 9: 1481-1486.
24. Puumalainen AM, Vapalahti M, Agrawal RS, Kossila M, Laukkanen J, et al. (1998) Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses. Hum Gene Ther 9: 1769-1774.
25. Kilby NJ, Snaith MR, Murray JA (1993) Site-specific recombinases: tools for genome engineering. Trends Genet 9: 413-21.
26. Leppänen P, Koota S, Kholová I, Koponen J, Fieber C, et al. (2005) Gene transfers of VEGF-A, VEGF-B, VEGF-C and VEGF-D have no effects on atherosclerosis in hypercholesterolemic LDL-receptor/ApoB48- deficient mice. Circulation 112: 1347-1352.
27. Hiltunen MO, Turunen MP, Turunen AM, Rissanen T, Ruuskanen M, et al. (2000) Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravascular and periadventitial gene delivery methods. FASEB J 14: 2230-2236.
28. Ylä-Herttuala S, Martin JF (2000) Cardiovascular gene therapy. Lancet 355: 213-22.
29. Belteki G, Haigh J, Kabacs N, Haigh K, Sison K, et al. (2005) Conditional and indusible transgene expression in mice through combinatorial use of cre-mediated recombination and tetracycline induction. Nucleic Acid Res 33: E51.
30. LeCouter J, Moritz DR, Li B, Phillips GL, Liang XH, et al. (2003) Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299: 890-893.
31. Hiltunen MO, Ruuskanen M, Huuskonen J, Mähönen AJ, Ahonen M, et al. (2003) Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo. FASEB J 17: 1147-1149.
32. Frith CH, Wiley L (1982) Spontaneous hepatocellular neoplasms and hepatic hemangiosarcomas in several strains of mice. Lab Lab Anim Sci 32: 157-62.
33. Lakso M, Sauer B, Mosinger B Jr, Lee EJ, Manning RW, et al. (1992) Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA 89: 6232-6236.
34. Jalkanen J, Leppänen P, Narvanen O, Greaves DR, Ylä -Herttuala S (2003) Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice. Atherosclerosis 169: 95-103.
35. Cursiefen C, Schlotzer-Schrehardt U, Kuchle M, Sorokin L, Breiteneder-Geleff S, et al. (2002) Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci 43: 2127-2135.
36. Bhardwaj S, Roy H, Gruchala M, Viita H, Kholova I, et al. (2003) Angiogenic Responses of Vascular Endothelial Growth Factors in Periadventitial Tissue. Hum Gene Ther 14: 1451-1462.