Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravascular and periadventitial gene delivery methods

FASEB Journal

Volumn 14, Issue 14, 2000, Pages 2230-2236

  Hiltunen, Mikko O ^a   Turunen, Mikko P ^a   Turunen, Anna Mari ^a   Rissanen, Tuomas T ^a   Laitinen, Marja ^a   Kosma, Veli Matti ^a   Ylä Herttuala, Seppo ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Adenovirus; Biodistribution; Vascular gene therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; LACTATE DEHYDROGENASE; RNA; VIRUS ANTIBODY; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY WALL; ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE; TRANSGENE;

ADENOVIRIDAE; ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033729780     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0145com     Document Type: Article

References (19)

1. Cardiovascular gene therapy
2. Gene transfer into the carotid artery using an adventitial collar: Comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses
3. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
4. Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses
5. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes
6. Site-specific gene expression in vivo by direct gene transfer into the arterial wall
7. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector
8. Genetic modification of the vessel wall. Comparison of surgical and catheter-based techniques for delivery of recombinant adenovirus
9. Evaluating the potential of germ line transmission after intravenous administration of recombinant adenovirus in the C3H mouse
10. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus
11. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
12. Analysis of adenoviral transport mechanisms in the vessel wall and optimization of gene transfer using local delivery catheters
13. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein
14. Antibody detection
15. Virus treatment questioned after gene therapy death
16. HMG CoA reductase inhibitors. In vivo effects on carotid intimal thickening in normocholesterolemic rabbits
17. Dexamethasone influences intimal thickening and vascular reactivity in the rabbit collared carotid artery
18. Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration