Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: A novel mechanism for acquisition of cross-reactivity by an autoantibody

Molecular Immunology

Volumn 42, Issue 1, 2005, Pages 39-48

  Kumar, Sanjeev ^a,b,f   Nagl, Sylvia ^c   Kalsi, Jatinderpal K ^a   Ravirajan, Chelliah T ^a   Athwal, Dee ^d   Latchman, David S ^e   Pearl, Laurence H ^b   Isenberg, David A ^a  

^a Univ C   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UCB PHARMA   (Belgium)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cross reactivity; Fabs; Heavy light chain shuffling; Human anti cardiolipin 2 GPI antibodies; Lambda kappa antibodies; Light chain; Molecular cloning

Indexed keywords

AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN; PHOSPHOLIPID ANTIBODY; PROTEIN P185;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; CROSS REACTION; HYBRID; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; THREE DIMENSIONAL IMAGING;

ANTIBODIES, ANTIPHOSPHOLIPID; ANTIBODY SPECIFICITY; AUTOANTIBODIES; BETA 2-GLYCOPROTEIN I; BINDING SITES; CLONING, MOLECULAR; CROSS REACTIONS; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING;

EID: 5444256422     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2004.07.012     Document Type: Article

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