Anti-β2-glycoprotein I (β2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the β2GPI binding to phospholipids

Journal of Clinical Investigation

Volumn 99, Issue 9, 1997, Pages 2260-2268

  Takeya, Hiroyuki ^a   Mori, Tatsuyuki ^a   Gabazza, Esteban C ^a   Kuroda, Kenji ^a   Deguchi, Hiroshi ^a   Matsuura, Eiji ^b   Ichikawa, Kenji ^b   Koike, Takao ^b   Suzuki, Koji ^a  

^a MIE UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

antiphospholipid; apolipoprotein; autoantobodies; phospholipid; prothrombin

Indexed keywords

APOLIPOPROTEIN; AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; LUPUS ANTICOAGULANT; MONOCLONAL ANTIBODY; PHOSPHOLIPID; PROTEIN ANTIBODY; PROTHROMBIN; THROMBIN; BLOCKING ANTIBODY; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN G; PROTHROMBINASE COMPLEX; SNAKE VENOM;

ANIMAL CELL; ANTICOAGULATION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AUTOIMMUNITY; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; VASCULAR ENDOTHELIUM; ANIMAL; ANTIBODY SPECIFICITY; BAGG ALBINO MOUSE; BLOOD; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; EPITOPES; FACTOR V; FACTOR X; FACTOR XA; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; LUPUS COAGULATION INHIBITOR; MICE; MICE, INBRED BALB C; PHOSPHOLIPIDS; SNAKE VENOMS; THROMBIN;

EID: 0030610162     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119401     Document Type: Article

References (66)

1. Koike, T. 1994. Anticardiolipin antibodies and β2-glycoprotein I. Clin. Immunol. Immunopathol. 72:187-192.
2. Lozier, J., N. Takahashi, and F.W. Putnam. 1984. Complete amino acid sequence of human plasma β2-glycoprotein I. Proc. Natl. Acad. Sci. USA. 81:3640-3644.
3. Matsuura, E., M. Igarashi, Y. Igarashi, H. Nagase, K. Ichikawa, T. Yasuda, and T. Koike. 1991. Molecular definition of human β2-glycoprotein I (β2GPI) by cDNA cloning and inter-species differences of β2GPI in alteration of anticardiolipin binding. Int. Immunol. 3:1217-1221.
4. Kato, H., and K. Enjyoji. 1991. Amino acid sequence and location of the disulfide bonds in bovine β2-glycoprotein I: the presence of five Sushi domains. Biochemistry. 30:11687-11694.
5. Steinkasserer, A., P.N. Barlow, A.C. Willis, Z. Kertesz, I.D. Chambell, R.B. Sim, and D.G. Norman. 1992. Activity, disulfide mapping and structural modeling of the fifth domain of human β2-glycoprotein I. FEBS Lett. 313:193-197.
6. Hunt, J.E., R.J. Simpson, and S.A. Krilis. 1993. Identification of a region of β2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity. Proc. Natl. Acad. Sci. USA. 90:2141-2145.
7. Hunt, S.E., and S.A. Krilis. 1994. The fifth domain of β2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anti-cardiolipin antibodies. J. Immunol. 152:653-659.
8. Matsuura, E., M. Igarashi, Y. Igarashi, T. Katahira, H. Nagae, K. Ichikawa, D.A. Triplett, and T. Koike. 1995. Molecular studies on phospholipid-binding sites and cryptic epitopes appearing on β2-glycoprotein I structure recognized by anticardiolipin antibodies. Lupus. 4:S13-17.
9. Hagihara, Y., Y. Goto, H. Kisao, and T. Yoshimura. 1995. Role of the N- and C-terminal domains of bovine β2-glycoprotein I in its interaction with cardiolipin.y. Biochem. (Tokyo). 118:129-136.
10. Nonaka, M., Y. Matsuda, T. Shiroishi, K. Moriwaki, M. Nonaka, and S. Natsuume-Sakai. 1992. Molecular cloning of mouse β2-glycoprotein I and mapping of the gene to chromosome 11. Genomics. 13:1083-1087.
11. Schousboe, I. 1985. β2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood. 66:1086-1091.
12. Schousboe, I. 1988. Inositolphospholipid-accelerated activation of prekalikrein by activated factor XII and its inhibition by β2-glycoprotein I. Eur. J. Biochem. 176:629-636.
13. Nimpf, J., E.M. Bevers, P.H. Bomans, U. Till, H. Wurm, G.M. Kostner, and R.F.A. Zwaal. 1986. Prothrombinase activity of human platelets is inhibited by β2-glycoprotein-I. Biochim. Biophys. Acta. 884:142-149.
14. McNeil, H.P., R.J. Simpson, C.N. Chesterman, and S.A. Krilis. 1990. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: β2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA. 87:4120-4124.
15. Galli, M., P. Comfurius, C. Maassen, H.C. Hemker, M.H. DeBaets, P.J.C. Van Breda-Vriesman, T. Barbui, R.F.A. Zwaal, and E.M. Bevers. 1990. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet (N. Am. Ed.). 335:1544-1547.
16. Matsuura, E., Y. Igarashi, M. Fujimoto, K. Ichikawa, and T. Koike. 1990. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet (N. Am. Ed.) 336:177-178.
17. Koike, T., and E. Matsuura. 1991. What is the "true" antigen for anticardiolipin antibodies. Lancet (N. Am. Ed.). 337:671-672.
18. Roubey, R.A.S. 1994. Antibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies. Blood. 84:2854-2867.
19. Triplett, D.A. 1995. Antiphospholipid-protein antibodies: laboratory detection and clinical relevance. Thromb. Res. 78:1-31.
20. Matsuura, E., Y. Igarashi, T. Yasuda, D.A. Triplett, and T. Koike. 1994. Anticardiolipin antibodies recognize β2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J. Exp. Med. 179:457-462.
21. Roubey, R.A.S., R.A. Eisenberg, M.F. Harper, and J.B. Winfield. 1995. "Anticardiolipin" antibodies recognize β2-glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. J. Immunol. 154:954-960.
22. Thiagarajan, P., S.S. Shapiro, and L. De Marco. 1980. Monoclonal immunoglobulin M coagulation inhibitor with phospholipid specificity: mechanism of a lupus anticoagulant. J. Clin. Invest. 66:397-405.
23. Exner, T., D.A. Triplett, D. Taberner, and S.J. Machin. 1991. Guidelines for testing and revised criteria for lupus anticoagulants. Thromb. Haemostasis. 65:320-325.
24. Lupus anticoagulant working party. 1991. Guidelines on testing for the lupus anticoagulant. J. Clin. Pathol. (Lond.). 44:885-889.
25. Bevers, E.M., M. Galli. T. Barbui, P. Comfurius, and R.F.A. Zwaal. 1991. Lupus anticoagulant IgGs (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb. Haemostasis. 66:629-632.
26. Galli. M., P. Comfurius, T. Barbui, R.F.A. Zwaal, and E.M. Bevers. 1992. Anticoagulant activity of β2-glycoprotein I is potentiated by a distinct group of anticardiolipin antibodies. Thromb. Haemostasis. 68:297-300.
27. McNeil, H.P., C.N. Chesterman, and S.A. Krilis. 1991. Immunology and clinical importance of antiphospholipid antibodies. Adv. Immunol. 49:193-280.
28. Triplett, D.A. 1993. Antiphospholipid antibodies and thrombosis: a consequence, coincidence, or cause? Arch. Pathol. Lab. Med. 117:78-88.
29. Arnout, J. 1996. The pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin-induced thrombocytopenia. Thromb. Haemostasis. 75:536-541.
30. Viard, J.-P., Z. Amoura, and J.-F. Bach. 1992. Association of anti-β2-glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus. Am. J. Med. 93:181-186.
31. Martinuzzo, M.E., R.R. Forastiero, and L.O. Carreras. 1995. Anti-β2-glycoprotein I antibodies: detection and association with thrombosis. Br. J. Haematol 89:397-402.
32. Ginsberg, J.S., C. Demers, P. Brill-Edward, M. Johnson, R. Bona, R.F. Burrows, J. Weitz, and J.A. Denburg. 1993. Increased thrombin generation and activation in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for a prothrombotic state. Blood. 81:2958-2963.
33. Galli, M., G. Finazzi, E.M. Bevers, and T. Barbui. 1995. Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and β2-glycoprotein I-dependent antiphospholipid antibodies. Blood. 86:617-623.
34. Blank, M., J. Cohen, V. Toder, and Y. Shoenfeld. 1991. Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc. Natl. Acad. Sci. USA. 88:3069-3073.
35. Bakimer, R., P. Fishman, M. Blank, B. Sredni, M. Djaldetti, and Y. Shoenfeld. 1992. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J. Clin. Invest. 89:1558-1563.
36. Gharavi, A.E., LR. Sammaritano, J. Wen, and K.B. Elkon. 1992. Induction of antiphospholipid autoantibodies by immunization with β2-glycoprotein I (apolipoprotein H). J. Clin. Invest. 90:1105-1109.
37. Blank, M., D. Faden, A. Tincani, J. Kopolovic, I. Goldberg, B. Gilburd, F. Allegri, G. Balestrieri, G. Valesini, and Y. Shoenfeld. 1994. Immunization with anticardiolipin cofactor (β2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J. Autoimmun. 7:441-455.
38. Simantov, R., J.M. LaSala, S.K. Lo, A.E. Gharavi, L.R. Sammaritano, J.E. Salmon, and R.L. Silverstein. 1995. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J. Clin. Invest. 96:2211-2219.
39. Kornberg, A., M. Blank, S. Kaufman, and Y. Shoenfeld. 1994. Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J. Immunol. 153:1328-1332.
40. Ichikawa, K., M.A. Khamashta, T. Koike, E. Matsuura, and G.R.V. Hughes. 1994. β2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis Rheum. 37:1453-1461.
41. Hashimoto, Y., M. Kawamura, K. Ichikawa, T. Suzuki, T. Sumida, S. Yoshida, E. Matsuura, S. Ikehara, and T. Koike. 1992. Anticardiolipin antibodies in NZW × BXSB F1 mice: a model of antiphospholipid syndrome. J. Immunol. 149:1063-1068.
42. Igarashi, M., E. Matsuura, Y. Igarashi, H. Nagae, K. Ichikawa, D.A. Triplett, and T. Koike. 1996. Human β2-glycoprotein I as an anticardiolipin cofactor determined using deleted mutants expressed by a baculovirus system Blood. 87:3262-3270.
43. Igarashi, M., E. Matsuura, Y. Igarashi, H. Nagae, Y. Matsuura, K. Ichikawa, T. Yasuda, D.R. Voelker, and T. Koike. 1993. Expression of anticardiolipin cofactor, human β2-glycoprotein I, by a baculovirus/insect cell system. Clin. Exp. Immunol. 93:19-25.
44. Miletich, J.P., G.J. Broze, and P.W. Majerus. 1980. The synthesis of sullated dextran beads for isolation of human plasma coagulation factors II, IX, and X. Anai Biochem. 105:304-310.
45. Iino, M., H. Takeya, J. Nishioka, T. Nakagaki, K. Tamura, and K. Suzuki. 1994. The role of human factor X activation peptide in activation of factor X by factor IXa. J. Biochem. (Tokyo). 116:335-340.
46. Suzuki, K., B. Dahlbäck, and J. Stenflo. 1982. Thrombin-catalyzed activation of human coagulation factor V. J. Biol. Chem. 257:6556-6564.
47. Kane, W.H., and P.W. Majerus. 1981. Purification and characterization of human coagulation factor V. J. Biol. Cham. 256:1002-1007.
48. Kostetskii, E., N.I. Gerasimenko, and N.F. Kushnerova. 1977. The phospholipid composition of organs and tissues of rabbit. Biokhimiya. 42:671-676.
49. Mori, T., H. Takeya, J. Nishioka, E.G. Gabazza, and K. Suzuki. 1996 β2-Glycoprotein I modulates the anticoagulant activity of activated protein C on the phospholipid surface. Thromb. Haemostasis. 70:598-602.
50. Smirnov, M.D., and C.T. Esmon. 1994. Phosphatidyl-ethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C. J. Biol. Chem. 269:816-819.
51. 2+-dependent epitope. Eur. J. Biochem. 165:39-45.
52. Tamoto, K., and J. Koyama. 1976. Non-precipitating guinea-pig antibodies as products of limited recognition of antigenic sites on the ovalbumin molecule. Immunology. 31:67-77.
53. Parham, P. 1983. On the fragmentation of monoclonal IgG1, IgG2a, and IgG2b from BALB/c mice. J. Immunol. 131:2895-2902.
54. Brandt, J.T. 1993. Antibodies to β2-glycoprotein I inhibit phospholipid dependent coagulation reactions. Thromb. Haemostasis. 75:598-602.
55. Mann, K.G., S. Krishnaswamy, and J.H. Lawson. 1992. Surface-dependent hemostasis. Semin. Hematol. 29:213-226.
56. Shi, W., B.H. Chong, and C.N. Chesterman. 1993. β2-Glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulants. Blood. 81:1255-1262.
57. McNeil, H.P., C.N. Chesterman, and S.A. Krilis. 1989. Anticardiolipin antibodies and lupus anticoagulants comprise separate antibody subgroups with different phospholipid binding characteristics. Br. J. Haematol. 73:506-513.
58. Bick, R.L., and F.B. William. 1994. Antiphospholipid and thrombosis syndromes. Semin. Thromb. Hemostasis. 20:3-15.
59. Exner, T., N. Sahman, and B. Trudinger. 1988. Separation of anticardiolipin antibodies from lupus anticoagulants on a phospholipid-coated polystyrene column. Biochem. Biophys. Res. Commun. 155:1001-1007.
60. Permpikul, P., L.V.M. Rao, and S.I. Rapaport. 1994. Functional and binding studies of the roles of prothrombin and β2-glycoprotein I in the expression of lupus anticoagulant activity. Blood. 83:2878-2892.
61. Oosting, J.D., R.H.W.M. Derksen, H.T.I. Entjes, B.M. Bouma, and P.G. de Groot. 1992. Lupus anticoagulant activity is frequently dependent on the presence of β2-glycoprotein I. Thromb. Haemostasis. 67:499-502.
62. Reeves, W.H., J. Blankson, and C.-H. Chou. 1992. Molecular analysis of autoantibody production. Concepts Immunopathol. 8:38-70.
63. Willems, G.M., M.P. Janssen, M.M.A.L. Pelsers, P. Comfurius, M. Galli, R.F.A. Zwaal, and E.M. Bevers. 1996. Role of divalency in the high-affinity binding of anticardiolipin antibodies-β2-glycoprotein I complexes to lipid membranes. Biochemistry. 35:13833-13842.
64. Malia, R.G., S. Kitchen, M. Greaves, and P.E. Preston. 1990. Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. Br. J. Haematol. 76:101-107.
65. Matsuda, J., M. Gotoh, K. Gohchi, K. Kawasugi, M. Tsukamoto, and N. Saitoh. 1995. Resistance to activated protein C activity of an anti-β2-glycoprotein I antibody in the presence of β2-glycoprotein I. Br. J. Haematol. 90:204-206.
66. Matsuda, J., K. Gohchi, K. Kawasugi, M. Gotoh, N. Saitoh, and M. Tsukamoto. 1995. Inhibitory activity of anti-β2-glycoprotein I on factor Va degradation by activated-protein C and its cofactor protein S. Am. J. Hematol. 49: 89-91.