Use of Phage Surface Expression to Analyze Regions of a Human V4-34(VH4-21)-Encoded IgG Autoantibody Required for Recognition of DNA: No Involvement of the 9G4 Idiotope

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2449-2454

  Mockridge, C Ian ^a   Chapman, Caroline J ^a   Spellerberg, Myfanwy B ^a   Isenberg, David A ^b   Stevenson, Freda K ^a  

^a UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; DNA; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN IDIOTYPE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIOPHAGE M13; BINDING COMPETITION; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; GENE VECTOR; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANTIBODIES, ANTINUCLEAR; BACTERIOPHAGE M13; BINDING, COMPETITIVE; DNA; GENES, IMMUNOGLOBULIN; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA;

EID: 0030587076     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. H gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum. 35:11.
2. H4-21 gene segment is required to encode anti-I and anti-i specificities. J. Immunol. 149: 2337.
3. Silberstein, L. E., L. C. Jefferies, J. Goldman, D. F. Friedman, J. S. Moore, P. C. Nowell, D. Roelcke, W. Pruzanski, J. Roudier, and G. J. Silverman. 1991. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood 78:2372.
4. H framework region 1 and complementarity determining region 3. J. Mol. Biol. 256:577.
5. H4-21 gene: a possible link between infection and lupus. Ann. NY Acad. Sci 764:427.
6. Silverman, G. J. 1992. Human antibody responses to bacterial antigens: studies of a model conventional antigen and a proposed model B cell superantigen. Int. Rev. Immunol. 9:57.
7. Goodglick, L., and J. Braun. 1994. Revenge of the microbes: superantigens of the T and B cell lineage. Am. J. Pathol. 144:623.
8. van Es, J. H., F. H. J. Gmelig Meyling, W. R. M. van der Akker, H. Aanstoot, R. H. W. M. Derksen, and T. Logtenberg. 1991. Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of SLE. J. Exp. Med. 173:461.
9. H4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J. Autoimm. 6:809.
10. Isenberg, D., M. Spellerberg, W. Williams, M. Griffiths, and F. Stevenson. 1993. Identification of the 9G4 idiotope in systemic lupus erythematosus. Br. J. Rheum. 32:876.
11. Shlomchik, M., M. Mascelli, H. Shan, M. Z. Radic, D. Pisetsky, A. Marshall-Rothstein, and M. Weigert. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265.
12. 1 mice. J. Exp. Med 173:731.
13. Radic, M. Z., M. A. Mascelli, J. Erikson, H. Shan, and M. Weigert. 1991. Ig H and L chain contributions to autoimmune specificities. J. Immunol. 146:176.
14. v molecules. J. Immunol. 150:469.
15. Diamond, B., J. B. Katz, E. Paul, C. Aranow, D. Lustgarten, and M. D. Scharff. 1992. The role of somatic mutation in the parthogenic anti-DNA response. Annu. Rev. Immunol. 10:731.
16. Stevenson, F. K., M. Wrightham, M. J. Glennie, D. B. Jones, A. R. Cattan, T. Feizi, T. J. Hamblin, and G. T. Stevenson. 1986. Antibodies to shared idiotypes as agents for analysis and therapy for human B-cell tumors. Blood 68:430.
17. H4-21 variable region gene-associated epitope. Scand. J. Immunol. 34:509.
18. Logtenberg, T, M. E. M. Schutte, S. B. Ebeling, F. H. J. Gmelig-Meyling, and J. H. van Es. 1992. Molecular approaches to the study of human B-cell and (auto)antibody repertoire generation and selection. Immunol. Rev. 128:23.
19. Stevenson, F. K., G. J. Smith, J. North, T. J. Hamblin, and M. J. Glennie. 1989. Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinus of anti-I and anti-i specificity. Br. J. Haematol. 72:9.
20. VH4-21 gene segment. J. Exp. Med. 178:1419.
21. Ehrenstein, M., C. Longhurst, and D. A. Isenberg. 1993. Production and isotype switching of monoclonal anti-DNA antibodies from SLE patients. Clin. Exp. Immunol. 92:39.
22. H4-21 gene: a possible link between infection and lupus. Hum. Antibodies Hybridomas 6:52.
23. H4-21 gene segment. J. Immunol. 151: 1051.
24. Hoogenboom, H. R., A. D. Griffiths, K. S. Johnson, D. J. Chiswell, P. Hudson, and G. Winter. 1991. Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res. 19:4133.
25. Pope, A., J. Embleton, and R. Mernaugh. 1996. Building antibody gene repertoires. In Antibody Engineering: A Practical Approach. J. McCafferty, H. Hoogenboom, and D. Chiswell, eds. IRL press, Oxford, U.K. In press.
26. H4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching. Mol. Immunol. 32:347.
27. Lowman, H. B., S. H. Bass, N. Simpson, and J. A. Wells. 1991. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry 30:10832.
28. Garrard, L. J., M. Yang, M. P. O'Connell, R. F. Kelley, and D. J. Henner. 1991. Fab assembly and enrichment in a monovalent phage display system. Biotechnology 9:1373.
29. Eilat, D., and R. Fischel. 1991. Recurrent utilization of genetic elements in V regions of anti-nucleic acid antibodies from autoimmune mice. J. Immunol. 147: 361.
30. Radic, M. Z., J. Mackle, J. Erikson, C. Mol. W. F. Anderson, and M. Weigert. 1993. Residues that mediate DNA binding of autoimmune antibodies. J. Immunol. 150:4966.
31. Barbas, S. M., P. Ghazal, C. F. Barbas, and D. R. Burton. 1994. Recognition of DNA by synthetic antibodies. J. Am. Chem. Soc. 116:2161.
32. Barbas, S. M., H. J. Ditzel, E. M. Salonen, W.-P. Yang, G. J. Silverman, and D. R. Burton. 1995. Human autoantibody recognition of DNA. Proc. Natl. Acad. Sci. USA 92:2529.
33. Herron, J. N., X. M. He, D. W. Ballard, P. R. Blier, P. E. Pace, A. L. M. Bothwell, E. W. Voss Jr., and A. R. Edmundson. 1991. An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins Struct. Funct. Genet. 11:159.
34. Ibrahim, S. M., M. Weigert, C. Basu, J. Erikson, and M. Z. Radic. 1995. Light chain contribution to specificity in anti-DNA antibodies. J. Immunol. 155:3223.
35. Pewzner-Jung, Y., T. Simon, and D. Eilat. 1996. Structural elements controlling anti-DNA antibody affinity and their relationship to anti-phosphorylcholine activity. J. Immunol. 156:3065.