Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-κB in macrophages

Journal of Pharmacology and Experimental Therapeutics

Volumn 327, Issue 2, 2008, Pages 393-401

  Byung, Hak Kim ^a   Seong, Su Hong ^a   Soon, Woo Kwon ^a   Hwa, Young Lee ^a   Sung, Hyeran ^a   Lee, In Jeong ^a   Bang, Yeon Hwang ^a   Song, Sukgil ^a   Lee, Chong Kil ^a   Daehyun, Chung ^a   Byeongwoo, Ahn ^a   Nam, Sang Yoon ^a   Han, Sang Bae ^a   Kim, Youngsoo ^a  

^a Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DIARCTIGENIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIGNAN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARCTIUM; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; IC 50; IMMUNOBLOTTING; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARCTIUM; CELLS, CULTURED; CYTOKINES; DINOPROSTONE; DNA; FEMALE; GENE EXPRESSION REGULATION; INTERLEUKIN-6; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; ZYMOSAN;

EID: 54349107702     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.140145     Document Type: Article

References (38)

1. Atreya I, Atreya R, and Neurath MF (2008) NF-κB in inflammatory bowel disease. J Intern Med 263:591-596.
2. Bacher S and Schmitz ML (2004) The NF-κB pathway as a potential target for autoimmune disease therapy. Curr Pharm Des 10:2827-2837.
3. Baeuerle PA and Baltimore D (1988) IκB: a specific inhibitor of the NF-κB transcription factor. Science 242:540-546.
4. Brennan P and O'Neill LA (1998) Inhibition of nuclear factor κB by direct modification in whole cells: mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. Biochem Pharmacol 55:965-973.
5. Cho JY, Kim AR, Yoo ES, Baik KU, and Park MH (1999) Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-α and nitric oxide production, and lymphocyte proliferation. J Pharm Pharmacol 51:1267-1273.
6. Cho MK, Park JW, Jang YP, Kim YC, and Kim SG (2002) Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol 2:105-116.
7. DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, and Karin M (1996) Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol 16:1295-1304.
8. Feldmann M, Brennan FM, and Maini R (1998) Cytokines in autoimmune disorders. Int Rev Immunol 17:217-228.
9. Hirose M, Yamaguchi T, Lin C, Kimoto N, Futakuchi M, Kono T, Nishibe S, and Shirai T (2000) Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats. Cancer Lett 155:79-88.
10. Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, Kwan I, Pepin N, Lacoste J, Nguyen H, and Bensi G (1993) Characterization of a functional NF-κB site in the human interleukin 1β promoter: evidence for a positive autoregulatory loop. Mol Cell Biol 13:6231-6240.
11. Hwang BY, Lee JH, Jung HS, Kim KS, Nam JB, Hong YS, Paik SG, and Lee JJ (2003) Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-κB. Planta Med 69:1096-1101.
12. Ikeda Y, Adachi Y, Ishii T, Miura N, Tamura H, and Ohno N (2008) Dissociation of Toll-like receptor 2-mediated innate immune response to zymosan by organic solvent-treatment without loss of Dectin-1 reactivity. Biol Pharm Bull 31:13-18.
13. Jang YP, Kim SR, Choi YH, Kim J, Kim SG, Markelonis GJ, Oh TH, and Kim YC (2002) Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J Neurosci Res 68:233-240.
14. Jeng KC, Hou RC, Wang JC, and Ping LI (2005) Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-κB. Immunol Lett 97:101-106.
15. Kang HS, Lee JY, and Kim CJ (2008) Anti-inflammatory activity of arctigenin from Forsythiae fructus. J Ethnopharmacol 116:305-312.
16. Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18:621-663.
17. Kim BH, Roh E, Lee HY, Lee IJ, Ahn B, Jung SH, Lee H, Han SB, and Kim Y (2008) Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated gene transcription through inactivating inhibitory κB kinase β. Mol Pharmacol 73:1309-1318.
18. Lee JH, Hwang BY, Kim KS, Nam JB, Hong YS, and Lee JJ (2003) Suppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis. Biochem Pharmacol 66:1925-1933.
19. Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, and Karin M (1999) The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J Exp Med 189:1839-1845.
20. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, and Murphy WJ (1993) Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc Natl Acad Sci U S A 90:9730-9734.
21. Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, and Sakai T (2008) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep 19:721-727.
22. Moon KY, Hahn BS, Lee J, and Kim YS (2001) A cell-based assay system for monitoring NF-κB activity in human HaCat transfectant cells. Anal Biochem 292:17-21.
23. Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, Kitamura T, Kosugi A, Kimoto M, and Miyake K (2002) Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol 3:667-672.
24. Nose M, Fujimoto T, Takeda T, Nishibe S, and Ogihara Y (1992) Structural transformation of lignan compounds in rat gastrointestinal tract. Planta Med 58:520-523.
25. Park GY and Christman JW (2006) Nuclear factor κB is a promising therapeutic target in inflammatory lung disease. Curr Drug Targets 7:661-668.
26. Park SY, Hong SS, Han XH, Hwang JS, Lee D, Ro JS, and Hwang BY (2007) Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production. Chem Pharm Bull (Tokyo) 55:150-152.
27. Pokharel YR, Liu QH, Aryal DK, Kim YG, Woo ER, and Kang KW (2007) 7,7′-Dihydroxy bursehernin inhibits the expression of inducible nitric oxide synthase through NF-κB DNA binding suppression. Nitric Oxide 16:274-285.
28. Simon LS (1999) Role and regulation of cyclooxygenase-2 during inflammation. Am J Med 106:37S-42S.
29. 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory. Eur J Pharmacol 588:217-231.
30. Tak PP and Firestein GS (2001) NF-κB: a key role in inflammatory diseases. J Clin Invest 107:7-11.
31. Tanaka K, Hasegawa J, Asamitsu K, and Okamoto T (2007) Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor κB. Eur J Pharmacol 565:212-219.
32. Tian B and Brasier AR (2003) Identification of a nuclear factor κB-dependent gene network. Recent Prog Horm Res 58:95-130.
33. Tse AK, Wan CK, Zhu GY, Shen XL, Cheung HY, Yang M, and Fong WF (2007) Magnolol suppresses NF-κB activation and NF-κB regulated gene expression through inhibition of IκB kinase activation. Mol Immunol 44:2647-2658.
34. Uwe S (2008) Anti-inflammatory interventions of NF-κB signaling: potential applications and risks. Biochem Pharmacol 75:1567-1579.
35. Vasilev N, Momekov G, Zaharieva M, Konstantinov S, Bremner P, Heinrich M, and Ionkova I (2005) Cytotoxic activity of a podophyllotoxin-like lignan from Linum tauricum Willd. Neoplasma 52:425-429.
36. Yao J, Mackman N, Edgington TS, and Fan ST (1997) Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocytic cells: regulation by Egr-1, c-Jun, and NF-κB transcription factors. J Biol Chem 272:17795-17801.
37. Zamora R, Vodovotz Y, and Billiar TR (2000) Inducible nitric oxide synthase and inflammatory diseases. Mol Med 6:347-373.
38. Zhang Y, Broser M, and Rom WN (1994) Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-κB. Proc Natl Acad Sci U S A 91:2225-2229.