Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-α and nitric oxide production, and lymphocyte proliferation

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 11, 1999, Pages 1267-1273

  Cho, Jae Youl ^a,c   Kim, Ae Ra ^b   Yoo, Eun Sook ^a   Baik, Kyong Up ^a   Park, Myung Hwan ^a  

^a Daewoong Pharmaceutical Co Ltd   (South Korea)

^b Pusan National University   (South Korea)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARCTIGENIN; BUCLADESINE; CONCANAVALIN A; LIGNAN; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; TERIFLUNOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; SPLEEN CELL; T LYMPHOCYTE;

EID: 0033456148     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991777001     Document Type: Article

References (32)

1. Ayres, D. C., Loike, J. D. (1990) Lignans: Chemical, Biological and Clinical Properties. Cambridge University Press, Cambridge, p. 402
2. Beutler, B. (1995) TNF, immunity and inflammatory disease: lessons of the past decade. J. Invest. Med. 43: 227-235
3. Chae, S. H., Kim, P. S., Cho, J. Y., Park, J., Lee, J. H., Yoo, E. S., Baik, K. U., Lee, J., Park, M. H. (1998) Isolation and identification of inhibitory compounds on TNF-α production from Magnoliae fargesii. Arch. Pharm. Res. 21: 67-69
4. Cho, J. Y., Park, J., Yoo, E. S., Baik, K. U., Lee, J., Park, M. H. (1998a) Inhibitory effect of sesquiterpene lactones from Saussurea lappa on tumor necrosis factor-α production in murine macrophage-like cell. Planta Med. 64: 594-597
5. Cho, J. Y., Park, J., Yoo, E. S., Baik, K. U., Park, M. H. (1998b) Effect of ginseng saponin on tumor necrosis factor-α production and T cell proliferation. Yakhak Hoeji 43: 296-301
6. Cho, J. Y., Park, J., Yoo, E. S., Baik, K. U., Yoshikawa, K., Lee, J., Park, M. H. (1998c) Inhibitory effect of lignans isolated from Coptis japonica var. dissecta on TNF-α production in LPS-stimulated RAW264·7 cells. Arch. Pharm. Res. 21: 12-16
7. Ding, A., Nathan, C. F., Stuehr, D. J. (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 141: 2407-2418
8. D'Hellencourt, C. L., Diaw, L., Cornillet, P., Guenounou, M. (1996) Differential regulation of TNF-α, IL-1β, IL-6, IL-8, TNF-β, and IL-10 by pentoxifylline. Int. J. Immunopharmacol. 18: 739-748
9. Eich, E., Pertz, H., Kaloga, M., Schulz, J., Fesen, M. R., Mazumder, A., Pommier, Y. (1996) (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. J. Med. Chem. 39: 86-95
10. Han, B. H., Yang, H. O., Kang, Y. H., Kim, Y. C., Go, H. J., Suh, D.-Y. (1996) Studies on platelet activating factor (PAF) antagonists from Korean medicinal plants. Korean J. Med. Chem. 6: 128-134
11. Hirano, T., Gotoh, M., Oka, K. (1994) Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci. 55: 1061-1069
12. Hwang, D., Fischer, N. H., Jang, B. C., Tak, H., Kim, J. K., Lee, W. (1996) Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochem. Biophys. Res. Commun. 226: 810-818
13. Im, S. Y., Han, S. J., Ko, H. M., Choi, J. H., Chun, S. B., Lee, D. G., Ha, T. Y., Lee, H. K. (1997) Involvement of nuclear factor-κB in platelet-activating factor mediated tumor necrosis factor-α expression. Eur. J. Immunol. 27: 2800-2804
14. Jackson, J. R., Bolognese, B., Hillegass, L., Kassis, S., Adams, J., Griswold, D. E., Winkler, J. D. (1998) Pharmacological effects of SB 220025, a selective inhibitor of p38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease model. J. Pharmacol. Exp. Ther. 284: 687-692
15. Kang, H. S., Kim, Y. H., Lee, C. S., Lee, J. J., Choi, I., Pyun, K. H. (1996) Suppression of interleukin-1 and tumor necrosis factor-alpha production by acanthoic acid, (-)-pimara-9 (11),15-dien-19-oic acid, and its antifibrotic effects in vivo. Cell Immunol. 170: 212-221
16. Katsuyama, M., Ikegami, R., Karahashi, H., Amano, F., Sugimoto, Y., Ichikawa, A. (1998) Characterization of the LPS-stimulated expression of EP2 and EP4 prostaglandin E receptors in mouse macrophage-like cell line, J774.1. Biochem. Biophys. Res. Commun. 251: 727-731
17. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, G., McNulty, D., Blumenthal, M. J., Hets, J. R., Landvatter, S. W., Strickler, J. E., McLaughlin, M. M., Siemens, I. R., Fisher, S. M., Livi, G. P., White, J. R., Adams, J. L., Young, P. R. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739-746
18. Moncada, S., Palmer, R. M. J., Higgs, E. A. (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142
19. Moritani, S., Nomura, M., Takeda, Y., Miyamoto, K. (1996) Cytotoxic components of bardanae fructus (goboshi). Biol. Pharm. Bull. 19: 1515-1517
20. Nishibe, Tsukamoto, H., Hisada, S., Nikaido, T., Ohmoto, T., Sankawa, U. (1986) Inhibition of cyclic AMP phosphodiesterase by lignans and coumarins of Olea and Fraxinus barks. Shoyakugaku Zasshi 40: 89-94
21. Panayi, G. S., Lanchbury, J. S., Kingsley, G. H. (1992) The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 35: 729-735
22. Ruetten, H., Thiemermann, C. (1997) Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br. J. Pharmacol. 122: 59-70
23. Sajjadi, F. G., Takabayashi, K., Foster, A. C., Domingo, R. C., Firestein, G. S. (1996) Inhibition of TNF-α expression by adenosine: role of A3 adenosine receptors. J. Immunol. 156: 3435-3442
24. Sekut, L., Connolly, K. M. (1996) Pathophysiology and regulation of TNF-α in inflammation. Drug News Perspect. 9: 261-269
25. Shannon, E. J., Morales, M. J., Sandoval, F. (1997) Immunomodulatory assays to study structure-activity relationships of thalidomide Immunopharmacology 35: 203-212
26. Spink, J., Cohen, J., Evans, T. J. (1995) The cytokine responsive vascular smooth muscle cell enhancer of inducible nitric oxide synthase. Activation by nuclear factor-κB. J. Biol. Chem. 270: 29541-29547
27. Tamma, S. L., Sundaram, S. K., Lev, M. C., Coico, R. F. (1996) Inhibition of sphingolipid synthesis down-modulates CD4 expression by peripheral blood T lymphocytes and T lymphoma cells. Biochem. Biophys. Res. Commun. 27: 916-921
28. Umehara, K., Nakamura, M., Miyase, T., Kuroyanagi, M., Ueno, A. (1996) Studies on differentiation inducers. VI. Lignan derivatives from Arctium fructus. Chem. Pharm. Bull. 44: 2300-2304
29. Vlietinck, A. J., de Bruyne, T., Apers, S., Pieters, L. A. (1998) Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med. 64: 97-109
30. Wang, S., Yan, L., Wesley, R. A., Danner, R. L. (1997) Nitric oxide increases tumor necrosis factor production in differentiated U937 cells by decreasing cyclic AMP. J. Biol. Chem. 272: 5959-5965
31. Wolkow, P. P. (1998) Involvement and dual effects of nitric oxide in septic shock. Inflamm. Res. 47: 152-166
32. Xu, X., Williams, J. W., Bremer, E. G., Finnegan, A., Chong, A. S. F. (1995) Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J. Biol. Chem. 270: 12398-12403