Neuroprotective effect of sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury

Journal of Neurochemistry

Volumn 107, Issue 4, 2008, Pages 918-927

  Hashimoto, Manabu ^a   Ishii, Kunihiro ^b   Nakamura, Yasuko ^a   Watabe, Kazuhiko ^c   Kohsaka, Shinichi ^a   Akazawa, Chihiro ^a,b  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Brain derived neurotrophic factor; Nerve injury; Real time polymerase chain reaction; Schwann cells; Sciatic nerve; Sonic hedgehog

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; RECOMBINANT PROTEIN; RECOMBINANT SONIC HEDGEHOG PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CRUSH TRAUMA; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; LUMBAR SPINAL CORD; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; RAT; SCHWANN CELL; SCIATIC NEUROPATHY; SPINAL CORD MOTONEURON; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MOTOR NEURONS; RATS; RATS, WISTAR; RNA, MESSENGER; S100 PROTEINS; SCHWANN CELLS; SCIATIC NEUROPATHY; TIME FACTORS; TRANSFECTION; UP-REGULATION;

ERINACEIDAE; RATTUS;

EID: 54349096878     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05666.x     Document Type: Article

References (32)

1. Akazawa C., Tsuzuki H., Nakamura Y., Sasaki Y., Ohsaki K., Nakamura S., Arakawa Y. Kohsaka S. (2004) The upregulated expression of sonic hedgehog in motor neurons after rat facial nerve axotomy. J. Neurosci. 24, 7923 7930.
2. Aszmann O. C., Korak K. J., Kropf N., Fine E., Aebischer P. Frey M. (2002) Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions. Plast. Reconstr. Surg. 110, 1066 1072.
3. Bajestan S. N., Umehara F., Shirahama Y., Itoh K., Sharghi-Namini S., Jessen K. R., Mirsky R. Osame M. (2006) Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. J. Neurobiol. 66, 243 255.
4. Berman D. M., Karhadkar S. S., Maitra A. et al. (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425, 846 851.
5. Briscoe J., Sussel L., Serup P., Hartigan-O'Connor D., Jessell T. M., Rubenstein J. L. Ericson J. (1999) Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398, 622 627.
6. Chen J. K., Taipale J., Cooper M. K. Beachy P. A. (2002) Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16, 2743 2748.
7. Cosgaya J. M., Chan J. R. Shooter E. M. (2002) The neurotrophin receptor p75NTR as a positive modulator of myelination. Science (New York, NY) 298, 1245 1248.
8. Cotrina M. L., Gonzalez-Hoyuela M., Barbas J. A. Rodriguez-Tebar A. (2000) Programmed cell death in the developing somites is promoted by nerve growth factor via its p75(NTR) receptor. Dev. Biol. 228, 326 336.
9. Ernfors P., Bengzon J., Kokaia Z., Persson H. Lindvall O. (1991) Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron 7, 165 176.
10. Friedman B., Kleinfeld D., Ip N. Y., Verge V. M., Moulton R., Boland P., Zlotchenko E., Lindsay R. M. Liu L. (1995) BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons. J. Neurosci. 15, 1044 1056.
11. Funakoshi H., Frisen J., Barbany G., Timmusk T., Zachrisson O., Verge V. M. Persson H. (1993) Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123, 455 465.
12. Hahn H., Wojnowski L., Miller G. Zimmer A. (1999) The patched signaling pathway in tumorigenesis and development: lessons from animal models. J. Mol. Med. 77, 459 468.
13. Hammarberg H., Piehl F., Cullheim S., Fjell J., Hokfelt T. Fried K. (1996) GDNF mRNA in Schwann cells and DRG satellite cells after chronic sciatic nerve injury. Neuroreport 7, 857 860.
14. Hoke A., Cheng C. Zochodne D. W. (2000) Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats. Neuroreport 11, 1651 1654.
15. Houenou L. J., Oppenheim R. W., Li L., Lo A. C. Prevette D. (1996) Regulation of spinal motoneuron survival by GDNF during development and following injury. Cell Tissue Res. 286, 219 223.
16. Ito Y., Wiese S., Funk N., Chittka A., Rossoll W., Bommel H., Watabe K., Wegner M. Sendtner M. (2006) Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells. Proc. Natl Acad. Sci. USA 103, 7871 7876.
17. Lamm M. L., Catbagan W. S., Laciak R. J., Barnett D. H., Hebner C. M., Gaffield W., Walterhouse D., Iannaccone P. Bushman W. (2002) Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev. Biol. 249, 349 366.
18. Lindvall O., Kokaia Z., Bengzon J., Elmer E. Kokaia M. (1994) Neurotrophins and brain insults. Trends Neurosci. 17, 490 496.
19. Loers G. Schachner M. (2007) Recognition molecules and neural repair. J. Neurochem. 101, 865 882.
20. Meyer M., Matsuoka I., Wetmore C., Olson L. Thoenen H. (1992) Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119, 45 54.
21. Richardson W. D., Pringle N. P., Yu W. P. Hall A. C. (1997) Origins of spinal cord oligodendrocytes: possible developmental and evolutionary relationships with motor neurons. Dev. Neurosci. 19, 58 68.
22. Riobo N. A., Lu K. Emerson Jr. C. P. (2006) Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle 5, 1612 1615.
23. Soula C., Danesin C., Kan P., Grob M., Poncet C. Cochard P. (2001) Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism. Development 128, 1369 1379.
24. Stone D. M., Hynes M., Armanini M. et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129 134.
25. Timmusk T., Palm K., Metsis M., Reintam T., Paalme V., Saarma M. Persson H. (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10, 475 489.
26. Turner T. T., Bang H. J., Attipoe S. A., Johnston D. S. Tomsig J. L. (2006) Sonic hedgehog pathway inhibition alters epididymal function as assessed by the development of sperm motility. J. Androl. 27, 225 232.
27. te Welscher P., Zuniga A., Kuijper S., Drenth T., Goedemans H. J., Meijlink F. Zeller R. (2002) Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science (New York, NY) 298, 827 830.
28. Winer J., Jung C. K., Shackel I. Williams P. M. (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem. 270, 41 49.
29. Xie J., Murone M., Luoh S. M. et al. (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391, 90 92.
30. Xu Q. G., Midha R., Martinez J. A., Guo G. F. Zochodne D. W. (2008) Facilitated sprouting in a peripheral nerve injury. Neuroscience 152, 877 887.
31. Yamada Y., Shimizu K., Nitta A., Soumiya H., Fukumitsu H. Furukawa S. (2004) Axonal regrowth downregulates the synthesis of glial cell line-derived neurotrophic factor in the lesioned rat sciatic nerve. Neurosci. Lett. 364, 11 15.
32. Zhang J. Y., Luo X. G., Xian C. J., Liu Z. H. Zhou X. F. (2000) Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents. Eur. J. Neurosci. 12, 4171 4180.