Mutation in pfmdr1 gene in chloroquine-resistant Plasmodium falciparum isolates, Southeast Iran

International Journal of Infectious Diseases

Volumn 12, Issue 6, 2008, Pages 630-634

  Jalousian, Fatemeh ^a   Dalimi, Abdolhossein ^a   Samiee, Siamak Mirab ^b   Ghaffarifar, Fatemeh ^a   Soleymanloo, Faramarz ^c   Naghizadeh, Ramin ^c  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b MINISTRY OF HEALTH AND MEDICAL EDUCATION   (Iran)

^c Day General Hospital   (Iran)

Author keywords

Chloroquine resistance; Iran; pfmdr1; Plasmodium falciparum; Real time PCR

Indexed keywords

CHLOROQUINE;

ADOLESCENT; ADULT; ALLELE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IRAN; ISOLATION PROCEDURE; MALARIA; MUTATOR GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PFMDR1 GENE; PLASMODIUM FALCIPARUM; POINT MUTATION; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT FAILURE;

ANIMALS; ANTIMALARIALS; BASE SEQUENCE; CHLOROQUINE; DRUG RESISTANCE; HUMANS; IRAN; MALARIA, FALCIPARUM; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; TREATMENT FAILURE;

EID: 54349090766     PISSN: 12019712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijid.2008.01.004     Document Type: Article

References (20)

1. Sangster N., Batterham P., Chapman H.D., Duraisingh M., Le Jamber L., Shirley M., et al. Resistance to antiparasitic drugs; the role of molecular diagnosis. Int J Parasitol 32 (2002) 637-653
2. Foote S.J., Kyle D.E., Martin R.K., Oduola A.M., Forsyth K., Kemp D.J., et al. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345 (1990) 255-258
3. Duraisingh M.T., Jones P., Sambou I., Von Seidlein L., Pinder M., and Warhurst D.C. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 108 (2000) 13-20
4. Edrissian G.H., and Shahabi S. Preliminary study of the response of Plasmodium falciparum to chloroquine in Sistan and Baluchestan Province of Iran. Trans R Soc Trop Med Hyg 79 (1985) 563-564
5. Edrissian G.H., Nateghpoor M., Afshar A., Sayedzadeh A., Mohsseni G.H., Satvat M.T., et al. Monitoring the response of P. falciparum and P. vivax to antimalarial drugs in the malarious areas in Southeast Iran. Arch Iran Med 2 (1999) 61-66
6. Ursing J., Zakeri S., Gill J.P., and Bjorkman A. Quinoline resistance associated polymorphisms in the pfcrt, pfmdr1 and pfmrp genes of Plasmodium falciparum in Iran. Acta Trop 97 (2006) 352-356
7. World Health Organization. Monitoring antimalarial drug resistance. Consultation, 2001. WHO/CDS/CSR/EPH. Geneva: World Health Organization; 2002.
8. de Monbrison F., Raynauda D., Latour-Fondanaichea C., Staalb A., Favreb S., Kaisera K., et al. Real-time PCR for chloroquine sensitivity assay and for pfmdr1-pfcrt single nucleotide polymorphisms in Plasmodium falciparum. J Microbiol Methods 54 (2003) 391-401
9. Sadrizadeh B. Malaria in the world, in the eastern Mediterranean region and in Iran. Arch Iranian Med 2 (1999) 29-36
10. Warhurst D. New developments: chloroquine-resistance in Plasmodium falciparum. Drug Resist Update 4 (2001) 141-144
11. Khim N., Bouchier C., Ekala M.T., Incardona S., Lim P., Legrand E., et al. Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia. Antimicrob Agents Chemother 49 (2005) 3147-3152
12. Pickard A.L., Wongsrichanalai C., Purfield A., Kamwendo D., Emery K., Zalewski C., et al. Resistance to anti-malarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob Agents Chemother 47 (2003) 2418-2423
13. Dorsey G., Kamya M.R., Singh A., and Rosenthal P.J. Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr1 genes and clinical response to chloroquine in Kampala, Uganda. J Infect Dis 183 (2001) 1417-1420
14. Mayor A.G., Gomez-Olive X., Aponte J.J., Casimiro S., Mabunda S., Dgedge M., et al. Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique. J Infect Dis 183 (2001) 1413-1416
15. Pillai D.R., Labbe A.C., and Vanisaveth V. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J Infect Dis 183 (2001) 789-795
16. Lim P., Chy S., Ariey F., Incardona S., Chim P., Sem R., et al. pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia. Antimicrob Agents Chemother 47 (2003) 87-94
17. Vieira P.P., Das Gracas Alecrim M., Da Silva L.H., Gonzalez-Jimenez I., and Zalis M.G. Analysis of the pfcrt K76T mutation in Plasmodium falciparum isolates from the Amazon region of Brazil. J Infect Dis 183 (2001) 1832-1833
18. Wongsrichanalai C., Pickard A.L., Wernsdorfer W.H., and Meshnick S.R. Epidemiology of drug-resistant malaria. Lancet Infect Dis 2 (2002) 209-218
19. Schneider A.G., Premji Z., Felger I., Smith T., Abdulla S., Beck H.P., et al. A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by chloroquine treatment in Tanzania. Infect Genet Evol 1 (2002) 183-189
20. Price R.N., Uhlemann A.C., Brockman A., McGready R., Ashley E., Phaipun L., et al. Mefloquine resistance in Plasmodium falciparum increased Pfmdr1 gene copy number. Lancet 364 (2004) 438-447