New developments: Chloroquine-resistance in Plasmodium falciparum

Drug Resistance Updates

Volumn 4, Issue 3, 2001, Pages 141-144

  Warhurst, David ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; HEMIN; HEMOGLOBIN; HEMOZOIN; LYSINE; MEMBRANE PROTEIN; PROTEIN PFCRT; THREONINE; UNCLASSIFIED DRUG;

AFRICA; AMINO ACID SUBSTITUTION; CHILD; CHILDHOOD MORTALITY; DETOXIFICATION; DRUG SENSITIVITY; DRUG UPTAKE; ERYTHROCYTE METABOLISM; HUMAN; LYSOSOME; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW;

EID: 0035188383     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2001.0194     Document Type: Editorial

References (27)

1. Impact of chloroquine-resistance on malaria mortality
2. Childhood mortality during and after hospitalization in Western Kenya: Effect of malaria treatment regimes
3. Morphological effects of chloroquine on Plasmodium berghei in mice
4. Mode of action of chloroquine on Plasmodium berghei and P. cynomolgi
5. The structure of malaria pigment β-haematin
6. Lysosomes, pH and the anti-malarial action of chloroquine
7. Ferriprotoporphyrin IX fulfils the criteria for identification as the chloroquine receptor of malaria parasites
8. Plasmodium falciparum in owl monkeys: Drug resistance and chloroquine-binding capacity
9. Identification of distinct accumulation sites of 4-aminoquinoline in chloroquine sensitive and resistant Plasmodium berghei strains
10. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
11. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
12. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole
13. Chloroquine-resistance not linked to mdr-like genes in a Plasmodium falciparum cross
14. PGHI modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
15. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum
16. Complex polymorphisms in a ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa
17. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciporum
18. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
19. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCTIA)
20. Identification and characterization of Falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum
21. Association of cg2 and Pfmdr1 genotype with chloroquine resistance in field samples of Plasmodium falciparum from Nigeria
22. Plasmodium falciparum: Linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria
23. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr 1 gene
24. A molecular marker for chloroquine-resistant falciparum malaria
25. Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine
26. Plasmodium falciparum malaria in Laos: Chloroquine treatment outcome and predictive value of molecular markers
27. A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum