Transient Nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells

Cancer Research

Volumn 68, Issue 20, 2008, Pages 8260-8268

  Shen, Hong ^a   Moran, Diarmuid M ^a   Maki, Carl G ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; NUTLIN 3; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN;

APOPTOSIS; ARTICLE; CELL CLONE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL ISOLATION; CELL STRAIN HCT116; CONTROLLED STUDY; DIPLOIDY; DNA CONTENT; DNA REPLICATION; ENDOREDUPLICATION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TETRAPLOIDY; THERAPY RESISTANCE; WILD TYPE;

APOPTOSIS; CELL LINE, TUMOR; CYCLIN A; CYCLIN B; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA; DNA DAMAGE; DNA REPLICATION; DRUG RESISTANCE, NEOPLASM; G1 PHASE; G2 PHASE; HCT116 CELLS; HUMANS; IMIDAZOLES; NEOPLASMS; PIPERAZINES; POLYPLOIDY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 54249109490     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1901     Document Type: Article

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