Citral: Identifying a threshold for induction of dermal sensitization

Regulatory Toxicology and Pharmacology

Volumn 52, Issue 1, 2008, Pages 62-73

  Lalko, Jon ^a   Api, Anne Marie ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Citral; Dermal sensitization; Induction; Review; Threshold

Indexed keywords

CITRAL; FRAGRANCE;

ANIMAL TISSUE; ARTICLE; CONSUMER; CONTACT ALLERGY; GUINEA PIG; HUMAN; HUMAN TISSUE; LEMON; NO OBSERVED EFFECT LEVEL; NONHUMAN; ONLINE ANALYSIS; PRIMARY PREVENTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK MANAGEMENT; SCORING SYSTEM; SKIN SENSITIZATION; STANDARD;

ANIMALS; CONSUMER PRODUCT SAFETY; DERMATITIS, ALLERGIC CONTACT; HUMANS; MONOTERPENES; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PERFUME; RISK ASSESSMENT; RISK MANAGEMENT; SKIN TESTS;

CITRUS LIMON;

EID: 54249095239     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.01.006     Document Type: Article

References (89)

1. Api A.M. Quenching of citral, cinnamaldehyde and phenylacetaldehyde sensitization in human repeated insult patch tests. Contact Dermatitis 42 Suppl 2 (2000) 40
2. Api A.M. Sensitization methodology and primary prevention of the research institute for fragrance materials. Dermatology 205 (2002) 84-87
3. Api A.M., and Isola D. Quenching of citral sensitization demonstrated in a human repeated insult patch test. Contact Dermatitis 46 Suppl 4 (2000) 37
4. Api A.M., Basketter D.A., Cadby P.A., Cano M.-F., Ellis G., Gerberick F., Griem P., McNamee P.M., Ryan C.A., and Safford B. Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Reg. Toxicol. Pharmacol. 52 (2008) 3-23
5. Arctander S. Perfume and Flavor Chemicals (Aroma Chemicals) vol. I (A-J) (1969), Steffen Arctander Publisher, Montclair, NJ
6. 14C-labelled citral. Acta Derm. Venereol. 63 (1983) 93-96
7. Basketter D.A., and Allenby C.F. Studies of the quenching phenomenon in delayed contact hypersensitivity reactions. Contact Dermatitis 25 3 (1991) 160-171
8. Basketter D.A., Scholes E.W., Kimber I., Botham P.A., Hilton J., Miller K., Robbins M.C., Harrison P.T.C., and Waite S.J. Interlaboratory evaluation of the local lymph node assay with 25 chemicals and comparison with guinea pig test data. Toxicol. Methods 1 1 (1991) 30-43
9. Basketter D.A., and Scholes W. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food Chem. Toxicol. 30 1 (1992) 65-69
10. Basketter D. The value of animal assays and the quenching phenomenon. In: Frosch P.J., Johansen J.D., and White I.R. (Eds). Fragrances: Beneficial Adverse Effects (1998), Springer-Verlag, Berlin 166-174
11. Basketter D.A., Lea L.J., Dickens A., Briggs D., Pate I., Dearman R., and Kimber I. A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses. J. Appl. Toxicol. 19 (1999) 261-266
12. Basketter D. Quenching: fact or fiction?. Contact Dermatitis 43 5 (2000) 253-258
13. Basketter D.A., Blaikie L., Dearman R.J., Kimber I., Ryan C.A., Gerberick G.F., Harvey P., Evans P., White I.R., and Rycroft R.J.G. Use of the local lymph node assay for estimation of relative contact allergenic potential. Contact Dermatitis 42 (2000) 344-348
14. Basketter D.A., Wright Z., Gilmour N.J., Ryan C.A., Gerberick G.F., Robinson M.K., Dearman R.J., and Kimber I. Prediction of human sensitization potency using local lymph node assay EC3 values. Toxicologist 66 1-S (2002) 240
15. Basketter D., Clapp C., Safford B., Jefferies D., Kimber I., Dearman R., Ryan C., and Gerberick F. Correlation of LLNA and human skin sensitization thresholds. Toxicologist 84 S-1 (2005) 246
16. Bedoukian P.Z. Perfumery and Flavoring Synthetics. second ed. (1967), Elsiver Publishing Co., New York, NY pp. 182
17. Buehler E.V. Delayed contact hypersensitivity in the guinea pig. Arch. Dermatol. 91 (1965) 171-177
18. Cocchiara J., Letizia C.S., Lalko J., Lapczynski A., and Api A.M. Fragrance material review on cinnamaldehyde. Food Chem. Toxicol. 43 6 (2004) 867-923
19. DeGroot A.C., Coenraads P.J., Bruynzeel D.P., Jagtman B.A., Van Ginkel C.J.W., Noz K., Van der Valk P.G.M., Pavel S., Vink J., and Weyland J.W. Routine patch testing with fragrance chemicals in the Netherlands. Contact Dermatitis 42 (2000) 184-185
20. Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to Cosmetic Product. Official Journal of the European Union, L66, 26-35.
21. ECETOC (European Center for Ecotoxicology and Toxicology of Chemicals), 2003. Contact Sensitisation: Classification According to Potency. Technical Report No. 87, Brussels, Belgium.
22. Ford R.A., Domeyer B., Easterday O., Maier K., and Middleton J. Criteria for the development of a database for safety evaluation of fragrance ingredients. Reg. Toxicol. Pharmacol. 31 (2000) 161-181
23. Frosch P.J., Pilz B., Andersen K.E., Burrows D., Camarasa J.G., Dooms-Goossens A., Ducombs G., Fuchs T., Hannuksela M., Lachapelle J.M., Lahti A., Maibach H.I., Menne T., Rycroft R.J.G., Shaw S., Wahlberg J.E., White I.R., and Wilkinson J.D. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermatitis 33 5 (1995) 333-342
24. Frosch P.J., Johansen J.D., Menne T., Pirker C., Rastogi S.C., Andersen K.E., Bruze M., Goossens A., Lepoittevin J.P., and White R. Further important sensitizers in patients sensitive to fragrances. I. Reactivity to 14 frequently used chemicals. Contact Dermatitis 47 2 (2002) 78-85
25. Frosch P., Pirker C., Rastogi S., Andersen K.E., Bruze M., Goossens A., White I.R., Uter W., Johansen J.D., and Menne T. The new fragrance mix II-test results of a multicentre European study. Contact Dermatitis 50 3 (2004) 149
26. Frosch P.J., Rastogi S.C., Pirker C., Brinkmeier T., Andersen K.E., Bruze M., Svedman C., Goosens A., White I.R., Uter W., Arnau E.G., Lepoittevin J.-P., Johansen J.D., and Menne T. Patch testing with a new fragrance mix-reactivity to the individual constituents and chemical detection in relevant cosmetic products. Contact Dermatitis 52 4 (2005) 216-225
27. Gerberick G.F., Robinson M.K., Felter S.P., White I.R., and Basketter D.A. Understanding fragrance allergy using an exposure-based risk assessment approach. Contact Dermatitis 45 6 (2001) 333-340
28. Gerberick G.F., Vassallo J.D., Bailey R.E., Chaney J.G., Morrall S.W., and Lepoittevin J.-P. Development of a peptide reactivity assay for screening contact allergens. Toxicol. Sci. 81 2 (2004) 332-343
29. Goodwin B.F.J., and Johnson A.W. Single injection adjuvant test. Curr. Probl. Dermatol. 14 (1985) 201-207
30. Hanau D., Grosshans E., Barbier P., and Benezra C. The influence of limonene on induced delayed hypersensitivity to citral in guinea pigs. I. Histological study. Acta Derm. Venereol. 63 1 (1983) 1-7
31. Heydorn S., Johansen J.D., Andersen K.E., Basketter D., Bruze M., Karlberg A.T., White I., and Menne T. Identification of fragrances relevant to hand eczema. Contact Dermatitis 46 Suppl 4 (2002) 21-22
32. Heydorn S., Menne T., Andersen K.E., Bruze M., Svedman C., White I.R., and Basketter D.A. Citral a fragrance allergen and irritant. Contact Dermatitis 49 1 (2003) 32-36
33. Heydorn S., Johansen J.D., Andersen K.E., Bruze M., Svedman C., White I.R., Basketter D.A., and Menne T. Fragrance allergy in patients with hand eczema-a clinical study. Contact Dermatitis 48 6 (2003) 317-323
34. Hostynek J.J., Magee P.S., and Maibach H.I. Identification of fragrance sensitizers by QSAR. In: Frosch P.J., Johansen J.D., and White I.R. (Eds). Fragrances: Beneficial Adverse Effects (1998), Springer-Verlag, Berlin 57-65
35. IFRA (International Fragrance Association), 1980. Code of Practice, Standard on Citral, Brussels, Belgium.
36. IFRA (International Fragrance Association), 2003. Code of Practice, Standard on Cinnamaldehyde, Brussels, Belgium.
37. Ishihara M., Itoh M., Hosono K., and Nishimura M. Some problems with patch tests using fragrance materials. Skin Res. 23 6 (1981) 808-817
38. Ishihara M., Itoh M., Nishimura M., Kinoshita M., Kantoh H., Nogami T., and Yamada K. Closed epicutaneous test. Skin Res. 28 Suppl 2 (1986) 230-240
39. Itoh M., Ishihara M., Hosono K., Kantoh H., Kinoshita M., Yamada K., and Nishimura M. Results of patch tests conducted between 1978 and 1985 using cosmetic ingredients. Skin Res. 28 Suppl 2 (1986) 110-119
40. Itoh M., Hosono K., Kantoh H., Kinoshita M., Yamada K., Kurosaka R., and Nishimura M. Patch test results with cosmetic ingredients conducted between 1978 and 1986. J. Soc. Cosmet. Sci. 12 1 (1988) 27-41
41. Karlberg A.-T., Nilsson A.-M., Luthman K., and Nilsson J.L. Structural analogues inhibit the sensitizing capacity of carvone. Acta Derm. Venereol. 81 6 (2000) 398-402
42. Kligman A.M., and Epstein W. Updating the maximization test for identifying contact allergens. Contact Dermatitis 1 (1975) 231-239
43. Kligman, A.M., 1985. This Week's Citation Classic. Current Contents, ISI, 48, 18.
44. Kimber I., and Basketter D. The murine local lymph node assay: a commentary on collaborative studies and new directions. Food Chem. Toxicol. 30 (1992) 165-169
45. Kimber I., Dearman R.J., Scholes E.W., and Basketter D.A. The local lymph node assay: developments and applications. Toxicology 93 1 (1994) 13-31
46. Klecak G., Geleick H., and Frey J.R. Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. J. Soc. Cosmet. Sci. 28 (1977) 53-64
47. Kimber I., Basketter D.A., Butler M., Gamer A., Garrigue J.-.L., Gerberick G.F., Newsome C., Steiling W., and Vohr H.-W. Classification of contact allergens according to potency: proposals. Food Chem. Toxicol. 41 12 (2003) 1799-1809
48. Lalko J., and Api A.M. Potency of citral in the local lymph node assay. Int. J. Toxicol. 23 6 (2004) 393
49. Lalko J., and Api A.M. Potency estimations for several fragrance materials in the local lymph node assay and their correlation to human studies. Toxicologist 84 S-1 (2005) 246
50. Lalko J., and Api A.M. Investigation of the sensitization potential of various essential oils in the local lymph node assay (LLNA). Food Chem. Toxicol. 44 (2006) 739-746
51. Lawrence B.M. Progress in Essential Oils 1976-2000 (2003), Allured Publishing Corporation, Carol Stream, IL
52. Magnusson B., and Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol. 52 3 (1969) 268-276
53. Marzulli F.N., and Maibach H.I. Contact allergy: predictive testing in humans. In: Marzulli F.N., and Maibach H.I. (Eds). Advances in Modern Toxicology. Dermatotoxicology and Pharmacology, vol. 4 (1977), Hemisphere, London 353-371
54. Meyer F., and Meyer E. Absorption of ethereal oils and substances contained in them through the skin. Arzneimittel-Forschung 9 (1959) 516-519
55. McNamee P.M., Gilpin D.A., Robinson M.K., and Gerberick G.F. A review of critical factors in the conduct and interpretation of the human repeat insult patch test. Reg. Toxicol. Pharmacol. 52 (2008) 24-34
56. Mitchell J.C., Adams R.M., Glendenning W.E., Fisher A., Kanof N., Larsen W., Maibach H.I., Rudner E.J., Schnorr W., Storrs F., and Taylor J.S. Results of standard patch tests with substances abandoned. Contact Dermatitis 8 5 (1982) 336-337
57. Mutalik S., and Udupa N. Effect of some penetration enhancers on the permeation of glibenclamide and glipizide through mouse skin. Pharmazie 58 12 (2003) 891-894
58. NIH (National Institutes of Health), 1999. The murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals/compounds. Publication No. 99-4494, Bethesda, MD.
59. Nilsson A.-M., Luthman K., Nilsson J.L.G., and Karlberg A.-T. Structural analogues inhibit the sensitizing capacity of a contact allergen. Contact Dermatitis 46 Suppl 4 (2002) 37
60. Nishimura M., Ishihara M., Itoh M., Hosono K., and Kantoh H. Results of patch tests on cosmetic ingredients conducted between 1979 and 1982. Skin Res. 26 4 (1984) 945-954
61. Opdyke D.L.J. Inhibition of sensitization reactions induced by certain aldehydes. Food Cosmet. Toxicol. 14 3 (1976) 197-198
62. Opdyke D.L.J. Citral: fragrance raw material monograph. Food Chem. Toxicol. 17 3 (1979) 259-266
63. OECD (Organization for Economic Co-Operation and Development), 2002. Skin Sensitization: Local Lymph Node Assay. Guideline reference 429, Paris, France.
64. Ritz H.L., and Buehler E.V. Planning, conduct, and interpretation of guinea pig sensitization patch tests. In: Drill V.A., and Lazar P. (Eds). Current Concepts in Cutaneous Toxicity (1980), Academic Press, New York 25-40
65. RIFM (Research Institute for Fragrance Materials, Inc.), 1964a. Repeated insult patch test of citral in human subjects. Unpublished report from Flavors and Fragrances Inc., Report Number 14576. RIFM, Woodcliff Lake, NJ, USA.
66. RIFM (Research Institute for Fragrance Materials, Inc.), 1964b. Repeated insult patch test of citral in human subjects. Unpublished report from Flavors and Fragrances Inc., Report Number 14575. RIFM, Woodcliff Lake, NJ, USA.
67. RIFM (Research Institute for Fragrance Materials, Inc.), 1965. Repeated insult patch test of citral in human subjects. Unpublished report from Flavors and Fragrances Inc., Report Number 14577. RIFM, Woodcliff Lake, NJ, USA.
68. RIFM (Research Institute for Fragrance Materials, Inc.), 1971a. Repeated insult patch test on human subjects. RIFM Report Number 2730. RIFM, Woodcliff Lake, NJ, USA.
69. RIFM (Research Institute for Fragrance Materials, Inc.), 1971b. Appraisal of sensitizing powers by maximization testing in humans. RIFM Report Number 1805. RIFM, Woodcliff Lake, NJ, USA.
70. RIFM (Research Institute for Fragrance Materials, Inc.), 1971c. Appraisal of sensitizing powers by maximization testing in humans. RIFM Report Number 1805, June 9. RIFM, Woodcliff Lake, NJ, USA.
71. RIFM (Research Institute for Fragrance Materials, Inc.), 1972a. Maguire delayed hypersensitivity test of phenylacetaldehyde, citral & lemongrass in guinea pigs. RIFM Report Number 12479. RIFM, Woodcliff Lake, NJ, USA.
72. RIFM (Research Institute for Fragrance Materials, Inc.), 1972b. The contact-sensitization potential of fragrance materials by maximization testing in humans. RIFM Report Number 1804. RIFM, Woodcliff Lake, NJ, USA.
73. RIFM (Research Institute for Fragrance Materials, Inc.), 1972c. The contact-sensitization potential of fragrance materials by maximization testing in humans. RIFM Report Number 1804, March 14. RIFM, Woodcliff Lake, NJ, USA.
74. RIFM (Research Institute for Fragrance Materials, Inc.), 1972d. Sensitization study of citral on human skin. RIFM Report Number 12481. RIFM, Woodcliff Lake, NJ, USA.
75. RIFM (Research Institute for Fragrance Materials, Inc.), 1973. The determination of citral in cosmetic formulations. Unpublished report from Rodia. RIFM Report Number 12471. RIFM, Woodcliff Lake, NJ, USA.
76. RIFM (Research Institute for Fragrance Materials, Inc.), 1974a. Modified Maguire guinea pig maximization test of cinnamic aldehyde, phenylacetaldehyde, citral & eugenol for allergic contact dermatitis. RIFM Report Number 5746. RIFM, Woodcliff Lake, NJ, USA.
77. RIFM (Research Institute for Fragrance Materials, Inc.), 1974b. Report on human maximization studies. RIFM Report Number 1779, June 4. RIFM, Woodcliff Lake, NJ, USA.
78. RIFM (Research Institute for Fragrance Materials, Inc.), 1974c. Report on human maximization studies. RIFM Report Number 1779, June 5. RIFM, Woodcliff Lake, NJ, USA.
79. RIFM (Research Institute for Fragrance Materials, Inc.), 1974d. Report on human maximization studies. RIFM Report Number 1801, December 2. RIFM, Woodcliff Lake, NJ, USA.
80. RIFM (Research Institute for Fragrance Materials, Inc.), 1974e. Report on human maximization studies. RIFM Report Number 1779, August 22. RIFM, Woodcliff Lake, NJ, USA.
81. RIFM (Research Institute for Fragrance Materials, Inc.), 1982. Guinea pig skin sensitization test with citral. Unpublished report from Quest International, 12 February. Report Number 45768. RIFM, Woodcliff Lake, NJ, USA.
82. RIFM (Research Institute for Fragrance Materials, Inc.), 2003. Citral: the influence of ageing on sensitization potency. Overview report. RIFM Report Number 42022, March 21. RIFM, Woodcliff Lake, NJ, USA.
83. RIFM (Research Institute for Fragrance Materials, Inc.), 2004a. Local lymph node assay on citral. RIFM Report Number 45126. RIFM, Woodcliff Lake, NJ, USA.
84. RIFM (Research Institute for Fragrance Materials, Inc.), 2004b. Repeated insult patch test with citral. RIFM Report Number 47157. RIFM, Woodcliff Lake, NJ, USA.
85. RIFM (Research Institute for Fragrance Materials, Inc.), 2005a. Local lymph node assay with citral. RIFM Report Number 50882. RIFM, Woodcliff Lake, NJ, USA.
86. RIFM (Research Institute for Fragrance Materials, Inc.), 2005b. Local lymph node assay on with citral. RIFM Report Number 50883. RIFM, Woodcliff Lake, NJ, USA.
87. Sharp D.W. The sensitization potential of some perfume ingredients tested using a modified Draize procedure. Toxicology 9 3 (1978) 261-271
88. Smith C.K., and Hotchkiss S.A.M. Allergic Contact Dermatitis: Chemical and Metabolic Mechanisms (2001), Taylor & Francis Ltd., London pp. 151
89. Steltenkamp R.J., Booman K.A., Dorsky J., King T.O., Rothenstein A.S., Schwoeppe E.A., Sedlak R.I., Smith T.H.F., and Thompson G. Citral: a survey of consumer patch-test sensitization. Food Cosmet. Toxicol. 18 (1980) 413-417