SONU20176289, a compound combining partial dopamine D2 receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression

European Journal of Pharmacology

Volumn 598, Issue 1-3, 2008, Pages 43-50

  Michael Titus, Adina T ^a   Albert, Monika ^b   Michael, Gregory J ^a   Michaelis, Thomas ^c   Watanabe, Takashi ^c   Frahm, Jens ^c   Pudovkina, Olga ^d   van der Hart, Marieke G C ^b   Hesselink, Mayke B ^d   Fuchs, Eberhard ^b   Czéh, Boldizsár ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b GERMAN PRIMATE CENTER   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Adult neurogenesis; AMPA; Antidepressant; GluR2; Prefrontal cortex; Proton magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CREATINE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR 2; N ACETYLASPARTIC ACID; PIPERAZINE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; SONU 20176289; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; DISEASE MODEL; DRUG MECHANISM; MALE; MENTAL STRESS; NERVE CELL PLASTICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SCANDENTIA;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BLOTTING, WESTERN; BRAIN CHEMISTRY; BROMODEOXYURIDINE; DENTATE GYRUS; DEPRESSION; DOPAMINE AGONISTS; IMMUNOHISTOCHEMISTRY; INDOLES; MAGNETIC RESONANCE IMAGING; MALE; NEURONAL PLASTICITY; NOREPINEPHRINE; PIPERAZINES; PREFRONTAL CORTEX; RECEPTORS, AMPA; RECEPTORS, DOPAMINE D2; SEROTONIN UPTAKE INHIBITORS; SOCIAL ENVIRONMENT; STRESS, PSYCHOLOGICAL; TESTIS; TESTOSTERONE; TUPAIIDAE;

EID: 54149086889     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.09.006     Document Type: Article

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