Quantification of metabolic differences in the frontal brain of depressive patients and controls obtained by 1H-MRS at 3 Tesla

Investigative Radiology

Volumn 38, Issue 7, 2003, Pages 403-408

  Gruber, Stephan ^a   Frey, Richard ^a   Mlynárik, Vladimir ^a   Stadlbauer, Andreas ^a,b   Heiden, Angela ^a   Kasper, Siegfried ^a   Kemp, Graham J ^c   Moser, Ewald ^a,d  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

Absolute quantification; Brain; Creatine; Depression; High field; Proton magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CREATINE; INOSITOL; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; BRAIN LEVEL; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; FRONTAL LOBE; HIGH FIELD NUCLEAR MAGNETIC RESONANCE; HUMAN; MAGNETIC FIELD; MALE; METABOLIC RATIO; METABOLITE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS;

EID: 0037561211     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.rli.0000073446.43445.20     Document Type: Article

References (24)

1. Soares JC, Mann JJ. The anatomy of mood disorders - review of structural neuroimaging studies. Biol Psychiatry. 1997;41:86-106.
2. Frey R, Metzler D, Fischer P, et al. Myo-inositol in depressive and healthy subjects determined by frontal 1H-magnetic resonance spectroscopy at 1.5 Tesla. J Psych Res. 1998;32:411-420.
3. Frahm J, Bruhn H, Gyngell M, et al. Localized high-resolution proton NMR spectroscopy. NMR Biomed. 1988;1:1-10.
4. Kreis R, Ernst T, Ross BD. Absolute quantification of water and metabolites in the human brain. II. Metabolite concentrations. J Magn Reson B. 1993;102:9-19.
5. Keevil SF, Barbiroli B, Brooks JC, et al. Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localised proton studies of human brain. Magn Reson Imaging. 1998;16:1093-1106.
6. Barker BB, Soher BJ, Blackband SJ, et al. Quantification of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed. 1993;6:89-94.
7. 1H MRS using water as an internal standard. Magn Reson Imaging. 1993;11;107-118.
8. Büchli R, Boesiger P. Comparison of methods for the determination of absolute metabolite concentrations in human muscles by 31 P MRS. Magn Reson Med. 1993;30;552-558.
9. Gadian DG, Bates TE. Williams SR. Approaches of editing, assignment and interpretation of proton spectra. NMR Biomed. 1991;4:85-89.
10. Frahm J, Bruhn H, Gyngell ML, et al. Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites. Magn Reson Med. 1989; 11: 47-63.
11. Hänicke W, Michaelis T, Merboldt KD, et al. On the use of a fully automated data analysis method for in vivo MRS. Metabolite concentrations and relaxation times from proton spectra of human brain. Proc SMR. 1993;2:977.
12. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672-679.
13. Hájek M, Burian M, Dezortová M. Application of LCModel for quality control and quantitative in vivo 1H MR spectroscopy by short echo time STEAM sequence. MAGMA. 2000;10:6-17.
14. Hamilton M. Development of a rating scale for primary depressive illness. Br J Cos Clin Psychol. 1967;6:278-296.
15. Ernst T, Kreis R, Ross BD. Absolute quantification of water and metabolites in the human brain. I. Compartments and water. J Magn Reson B. 1993;102:1-8.
16. Gonen O, Gruber S, Li BS, et al. Multivoxel 3D proton spectroscopy in the brain at 1.5 versus 3.0 T:signal-to-noise ratio and resolution comparison. Am J Neuroradiol. 2001;22:1727-1731.
17. Mlynarik V, Gruber S, Moser E. Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla. NMR Biomed. 2001;14:325-331.
18. Hennig J, Pfister H, Ernst T, et al. Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy. NMR Biomed. 1992;5:193-199.
19. Deicken RF, Eliaz Y, Freiwell R, et al. Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder. Psychiatry Res. 2001;106:35-45
20. Auer DP, Schmid D, Meri Th, et al. Regional metabolic effects of sleep deprivation in depressed patients assessed by proton magnetic resonance spectroscopy. Proceedings of ISMRM, 2002.
21. Kemp GJ. Non-invasive methods for studying brain energy metabolism: What they show and what it means. Dev Neurosci. 2000;22:418-428.
22. Urenjak J, Williams SR, Gadian DG, et al. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci. 1993;13:981-989.
23. Chang L, Ernst T, Osborn D, et al. Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats. Arch Neurol. 1998;55: 291-293.
24. Soher BJ, van Zijl PC, Duyn JH, et al. Quantitative proton MR spectroscopic imaging of the human brain. Magn Reson Med. 1996; 35:356-363.