Etiologic theories of idiopathic scoliosis: Autonomic nervous system and the leptin-sympathetic nervous system concept for the pathogenesis of adolescent idiopathic scoliosis

Studies in Health Technology and Informatics

Volumn 140, Issue , 2008, Pages 197-207

  Burwell, R G ^a   Dangerfield, P H ^b   Moulton, A ^c   Anderson, S I ^d  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c KING S MILL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Hypothalamus; Idiopathic scoliosis; Leptin; Pathogenesis; Spine; Sympathetic nervous system

Indexed keywords

BIOCHEMISTRY; BONE; BRAIN; MAMMALS; METABOLISM; MUSCULOSKELETAL SYSTEM; NEUROPHYSIOLOGY;

HYPOTHALAMUS; IDIOPATHIC SCOLIOSIS; LEPTIN; PATHOGENESIS; SPINE; SYMPATHETIC NERVOUS SYSTEMS;

HORMONES;

LEPTIN; MELATONIN;

ADOLESCENT; ADRENERGIC SYSTEM; AUTONOMIC NERVOUS SYSTEM; BODY MASS; BODY POSTURE; FEMALE; HUMAN; PATHOPHYSIOLOGY; REVIEW; RISK FACTOR; SCOLIOSIS; SPINE; VERTEBRA;

ADOLESCENT; AUTONOMIC NERVOUS SYSTEM; BODY MASS INDEX; FEMALE; HUMANS; LEPTIN; MELATONIN; POSTURE; RISK FACTORS; SCOLIOSIS; SPINE; SYMPATHETIC NERVOUS SYSTEM; THORACIC VERTEBRAE;

EID: 54049138056     PISSN: 09269630     EISSN: 18798365     Source Type: Book Series    
DOI: 10.3233/978-1-58603-888-5-197     Document Type: Conference Paper

References (69)

1. Patel MS, Elefteriou F, The new field of neuroskeletal biology. Calc Tissue Int 2007, 80:337-347.
2. Schwartzman RJ, New treatments for reflex sympathetic dystrophy. New Eng J Med 2000, 343:654-656.
3. Pasco JA, Henry MJ, Sanders KM et al, Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong osteoporosis study. J Bone Miner Res 2004, 19:19-24
4. Rejnmark L, Vestergaard P, Kassem M et al, Fracture risk in perimenopausal women treated with beta-blockers Calc Tissue Int 2004, 75:365-372.
5. Cole AA, Burwell RG, Dangerfield, PH et al, Anthropometry, In: Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. State of the Art Reviews: Spine 2000, 14(2):411-421, Philadelphia, Hanley & Belfus Inc.
6. Sanders JO, Khoury JG, Kishan S et al, Predicting scoliosis progression from skeletal maturity; a simplified classification during adolescence. J Bone Joint Surg 2008, 90;540-553.
7. Skogland LB, Miller JA, Growth related hormones in idiopathic scoliosis. An endocrine basis of accelerated growth. Acta Orthop Scand 1980, 51(5):779-780.
8. Ahl T, Albertsson-Wikland K, Kalen R, Twenty-four hour growth hormone profiles in pubertal girls with idiopathic scoliosis. Spine 1988, 13(2):139-142.
9. Hagglund G, Karlberg J, Willner S, Growth in girls with adolescent idiopathic scoliosis. Spine 1992, 17:108-111.
10. Edelmann P, Gupta D, Hormonal investigations in adolescent idiopathic scoliosis. Acta Endocrinol (Kbh) 1971, 184 (Suppl):71.
11. Raczkowski JW, The concentrations of testosterone and estradiol in girls with adolescent idiopathic scoliosis. Neuroendocrinol Letters 2007, 28(3):302-304.
12. Castelein RM, Dieën JH van, Smit TH: The role of dorsal shear forces in the pathogenesis of adolescent idiopathic scoliosis - a hypothesis. Med Hypoth 2005, 65:501-508.
13. Burwell RG, Freeman BJC, Dangerfield PH et al, Etiologic theories of idiopathic scoliosis: neurodevelopmental concept of maturational delay of the CNS body schema ("body-in-the-brain"). In: Research into Spinal Deformities 5, Studies in Health Technology and Informatics Volume 123. Edited by Uyttendaele D and Dangerfield PH, Amsterdam, IOS Press; 2006, 72-79.
14. st SOSORT Instructional Course Lecture Book. The conservative scoliosis treatment, Studies in Health Technology and Informatics Volume 135, Edited by Grivas TB, Amsterdam IOS Press, 2008, 3-52.
15. Burwell RG, Dangerfield, PH, Freeman BJC. Etiologic theories of idiopathic scoliosis. Somatic nervous system and the NOTOM escalator concept as one component of the pathogenesis of adolescent idiopathic scoliosis. In: Research into Spinal Deformities 6, Studies in Health Technology and Informatics (This volume). Edited by Dangerfield PH, Amsterdam, IOS Press; 2008.
16. Machida M: Cause of idiopathic scoliosis. Spine 1999, 24:2576-2583.
17. Azeddine B, Letellier K, Wang DS et al, Molecular determinants of melatonin signaling dysfunction in adolescent idiopathic scoliosis. Clin Orthop Rel Res 2007, 462:45-52.
18. Brown SA, Kunz D, Dumas A et al, Molecular insights into human daily behavior. PNAS 2008, 105(5):1602-1607.
19. Cheung CSK, Lee WTK, Tse YK, Lee KM, Guo X, Qin L, Cheng JCY: Generalized osteopenia in adolescent idiopathic scoliosis. - association with abnormal pubertal growth, bone turnover, and calcium intake? Spine 2006, 31(2):330-338.
20. Suh KT, Lee S-S, Hwang SH et al, Elevated soluble receptor activity of nuclear factor-kB ligand and reduced bone mineral density in patients with adolescent idiopathic scoliosis. Eur Spine J 2007 16:1563-1569.
21. Smith FM, Latchford G, Hall RM et al, Indications of disordered eating behaviour in adolescents with idiopathic scoliosis. J Bone Joint Surg (Br) 2002, 84(3):392-394.
22. Davey RC, Cochrane T, Dangerfield PH et al, Anthropometry and body composition in females with adolescent idiopathic scoliosis. In International Research Society of Spinal Deformities Symposium 2004, Edited by Sawatzky BJ, University of British Columbia, 2004, 323-326.
23. Qiu Y, Sun X, Qiu X et al, Decreased circulating leptin level and its association with body and bone mass in girls with adolescent idiopathic scoliosis. Spine 2007,32(24):2703-2710.
24. Grivas TB, Arvaniti A, Maziotou C et al, Comparison of body weight and height between normal and scoliotic children. In Research into Spinal Deformities 4, Studies in Health Technology and Informatics Volume 91. Edited by Grivas TB. Amsterdam, IOS Press; 2002:47-53.
25. Burwell RG, Aujla RK, Kirby AS et al, Body mass index of girls in health influences menarche and skeletal maturation: a leptin-sympathetic nervous system focus on the trunk with hypothalamic asymmetric dysfunction in the pathogenesis of adolescent idiopathic scoliosis? In: Research into Spinal Deformities 6, Studies in Health Technology and Informatics (This volume). Edited by Dangerfield PH, Amsterdam, IOS Press; 2008.
26. Smith FM, Latchford GJ, Hall RM et al, Do chronic medical conditions increase the risk of eating disorder? A cross-sectional investigation of eating pathology in adolescent females with scoliosis and diabetes. Adol Health 2008, 42(1):58-63
27. Alborghetti A, Scimeca G, Costanzo G et al, The prevalence of eating disorders in adolescents with idiopathic scoliosis. Eat Disord 2008, 16(1):85-93.
28. Sevastik JA, The thoracospinal concept of the etiopathogenesis of idiopathic scoliosis. In: Etiology of Adolescent Idiopathic Scoliosis: Current Trends and Relevance to New Treatment Approaches, Edited by: Burwell RG, Dangerfield PH, Lowe TG, Margulies JY. State of the Art Reviews: Spine 2000, 14(2):391-400.
29. Sevastik J, Burwell RG, Dangerfield PH, A new concept for the etiopathogenesis of the thoracospinal deformity of idiopathic scoliosis: summary of an electronic focus group debate of the IBSE. Eur Spine J 2003. 12:440-450.
30. Sevastik J, Dysfunction of the autonomic nerve system (ANS) in the aetiopathogenesis of adolescent idiopathic scoliosis. In: Research into Spinal Deformities 3, Studies in Health Technology and Informatics Volume 88. Edited by Tanguy A, Peuchot B. Amsterdam, IOS Press; 2002:20-23.
31. Stokes IAF, Burwell RG, Dangerfield PH: Biomechanical spinal growth modulation and progressive adolescent scoliosis - a test of the 'vicious cycle' pathogenetic hypothesis: Summary of an electronic focus group debate of the IBSE. Scoliosis 2006,1:16 doi:10.1186/1748-7161-1-1
32. Iliopoulos P, Korovessis P, Koureas G et al, Asymmetric evolution of anterior chest wall blood supply in female adolescents with progressive right-convex thoracic idiopathic scoliosis. Eur Spine J 2007, 16:1343-1346.
33. Repko M, Horky D, Krbec M, Chaloupka R, Brichtova E, Lauschová I: The role of the autonomic nervous system in the etiology of idiopathic scoliosis: prospective electron microscopic and morphometric study. Childs Nerv Syst 2008, Jan 11 [EPub ahead of print].
34. Enslein K, Chan DPK, Multiparameter pilot study of adolescent idiopathic scoliosis. Spine 1987, 12(10):978-982.
35. Korr IM, Wright HM, Chace JA, Cutaneous patterns of sympathetic activity in clinical abnormalities of the musculoskeletal system. Acta Neurovegit 1964, 25:589-606.
36. Buijs RM, Scheer FA, Kreier F et al, Organization of circadian functions: integrartion with the body. Prog Brain Res 2006, 153:341-360.
37. Gil-Campos M, Aguilera CM, Canete R et al, Ghrelin: a hormone regulating food intake and energy homeostasis. Brit J Nutri 2006, 96(2):201-226.
38. Fekete C, Marks DL, Sarkar S et al, Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Endocrinol 2004, 145(11):4816-4821.
39. Song CK, Jackson PM, Harris RB et al, Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue. Am J Physiol, Regul Integr Comp. Physiol 2005, 289:R146-R1476.
40. Gomez JM, Serum leptin, insulin-like growth factor-1 components and sex hormone binding globulin. Relationship with sex, age and body composition in healthy population. Protein and Peptide Letters 2007,14(7):701-711.
41. Crown A, Clifton DK, Steiner RA. Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinol 2007, 86(3):175-182.
42. Ebling FJP, The neuroendocrine timing of puberty. Reproduction 2005, 129:675-683.
43. Kaplowitz PB, Link between body fat and the timing of puberty. Pediatrics 2008, 121, Supplement S208-S217.
44. Kauffman AS, Clifton DK, Steiner RA, Emerging ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci 2007, 30(10):504-51.
45. Plant TM, The role of KISS-1 in the regulation of puberty in higher primates. Eur J Endocrinol 2006, 155 Suppl 1:511-516.
46. Clayton PE, Gill MS, Hall CM et al, Serum leptin throughout childhood and adolescence. Clin Endocrinol 1997, 46:727-733.
47. Demerath EW, Towne B, Wisemandle W et al, Serun leptin concentration, body composition, and gonadal hormones during puberty. Intern J Obesity 1999, 23:678-685.
48. Gat-Yablonski, G, Phillip M, Leptin and regulation of linear growth. Curr Opin Clin Nutr Metab Care 2008, 11(3):303-308
49. Thomas T, The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol 2004, 4:295-300.
50. Iwaniec UT, Boghossian S, Lapke PD et al, Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice Peptides 2007, 28:1012-1019.
51. Lee NK, Sowa H, Hinoi, E et al, Endocrine regulation of energy metabolism by the skeleton. Cell 2007, 130:456-469.
52. Allison SJ, Baldock PA, Herzog H, The control of bone remodeling by neuropeptide Y receptors Peptides 2007, 28: 320-325.
53. Baldock PA, Allison SJ, Lundberg P et al, Novel role of Y1 receptors in the coordinated regulation of bone and energy. J Biol Chem 2007, 282(26):19092-19102.
54. Ducy P, Amling M, Takeda S et al, Leptin regulates bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000, 100:197-200.
55. Takeda S, Elefteriou F, Levasseur R et al, Leptin regulates bone formation by the sympathetic nervous system. Cell 2002, 111:303-317.
56. Semenkovich CF, Teitelbaum SL, Bone weighs in on obesity. Cell 2007, 130:409-411.
57. Bamshad M, Aoki VT, Adkison MG et al, Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol, Regul Integr Comp. Physiol 1998, 275:R291-R299.
58. Foster MT, Bartness TJ, Sympathetic but not sensory denervation stimulates white adipose proliferation. Am J Physiol Regul Integr Comp Physiol 2006, 291(6):R1630-1637.
59. Nissinen M, Heliovaara M, Seitsamo J et al, Trunk asymmetry, posture, growth, and risk of scoliosis. A three-year follow-up of Finnish prepubertal school children. Spine 1993, 19(1):8-13.
60. Guo X, Chau W-W, Chan Y-L, Cheng J-Y-C: Relative anterior spinal overgrowth in adolescent idiopathic scoliosis. Results of disproportionate endochondral-membranous bone growth. J Bone Joint Surg (Br) 2003, 85-B:1026-1031.
61. Burwell RG, Aujla RK, Freeman BJC et al, Patterns of extra-spinal left-right skeletal asymmetries in adolescent girls with lower spine scoliosis: relative lengthening of the ilium on the curve concavity and of right lower limb segments. In Research into Spinal Deformities 5, Studies in Health Technology and Informatics Volume 123. Edited by Uyttendaele D, Dangerfield PH, Amsterdam, IOS Press; 2006: 57-65.
62. Togari A, Adrenergic regulation of bone metabolism; possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells. Micros Res Techn 2002, 58(2):77-84.
63. Elmquist JK, Strewler GJ, Do neural signals remodel bone? Nature 2005,434:447-448.
64. Warren MP, Brooks-Gunn J, Hamilton LH et al, Scoliosis and fractures in young ballet dancers. Relation to delayed menarche and secondary amenorrhea. New Eng J Med 1986, 314(21):1348-1353.
65. Day G, Frawley K, Phillips B, McPhee TB, Labrom R, Askin G, Mueller P: The vertebral body growth plate in scoliosis: a primary disturbance in growth? Scoliosis 2008;3:3 doi 10.1186/1748-7161-3-3.
66. Azeddine B, Letellier K, Wang DS et al, Molecular determinants of melatonin signaling dysfunction in adolescent idiopathic scoliosis. Clin Orthop Rel Res 2007, 462:45-52.
67. Tanner JM, The interaction of hereditary and environment in the control of growth, Chapter 9 In Foetus into man. Physical growth from conception to maturity. Wells: Open Books Publ Co, 1978, pp150-153.
68. Finch CE, Nutrition and infection in developmental influences on aging. Chapter 4, In The biology of human longevity, inflammation, nutrition, and aging in the evolution of lifespan. Amsterdam: Elsevier, 2007, pp246-249.
69. Fogel RW, Costa DL, A theory of technophysio evolution, with some implications for forecasting population, health care costs, and pension costs. Demography 1997, 34(1):49-66.