PAK is regulated by PI3K, PIX, CDC42, and PP2Cα and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway

Journal of Biological Chemistry

Volumn 283, Issue 36, 2008, Pages 24949-24961

  Chan, Perry M ^a   Limsect, Louis ^a,b   Manser, Edward ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; AMINES; BRAIN; DISSOLUTION; FOCUSING; NUCLEIC ACIDS; PHOSPHORYLATION; RNA;

BIOCHEMICAL ACTIVITIES; BIOCHEMICAL ASSAYS; BRAIN EXTRACTS; DOMINANT NEGATIVES; EXCHANGE FACTORS; FOCAL ADHESIONS; GROWTH FACTORS; HYPEROSMOTIC SHOCKS; HYPEROSMOTIC STRESSES; INHIBITORY DOMAINS; INHIBITORY PEPTIDES; KINASE COMPLEXES; KINASE INHIBITORS; OVEREXPRESSION; POTENT ACTIVATORS; REDUCED STRESSES; RNA INTERFERENCES; SIGNALING PATHWAYS;

CHEMICAL ACTIVATION;

MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN CDC42; SORBITOL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; P21 ACTIVATED KINASE; PAK1 PROTEIN, HUMAN; PAK1 PROTEIN, RAT; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2CA PROTEIN, HUMAN; PPP2CA PROTEIN, RAT; PTEN PROTEIN, HUMAN; PTEN PROTEIN, RAT; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FOCAL ADHESION; HUMAN; HUMAN CELL; HYPEROSMOTIC STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RNA INTERFERENCE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; HELA CELL; METABOLISM; OSMOTIC PRESSURE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CDC42 GTP-BINDING PROTEIN; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; FOCAL ADHESIONS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; OSMOTIC PRESSURE; P21-ACTIVATED KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN PHOSPHATASE 2; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; RATS;

EID: 54049134839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801728200     Document Type: Article

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