Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection

Journal of Gene Medicine

Volumn 9, Issue 11, 2007, Pages 976-985

  Fukushima, Masayoshi ^a   Hattori, Yoshiyuki ^a   Tsukada, Hideo ^b   Koga, Kimiko ^a   Kajiwara, Eiichi ^a   Kawano, Kumi ^a   Kobayashi, Tsuneo ^a   Kamata, Katsuo ^a   Maitani, Yoshie ^a  

^a HOSHI UNIVERSITY   (Japan)

^b HAMAMATSU PHOTONICS K K   (Japan)

Author keywords

Adiponectin; Gene expression; Glucose uptake; Glucose lowering effect; Receptor targeting; STZ induced diabetic mice

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR; DEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; INSULIN; PLASMID DNA; SODIUM CHLORIDE; STREPTOZOCIN; TRIACYLGLYCEROL; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HYDRODYNAMICS BASED TRANSFECTION; HYPERGLYCEMIA; LIVER; MALE; MOUSE; NONHUMAN; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN TARGETING; SKELETAL MUSCLE; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL;

4-CHLORO-7-NITROBENZOFURAZAN; ADIPONECTIN; ANIMALS; CELL LINE, TUMOR; DEOXYGLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEPATOCYTES; HUMANS; INJECTIONS; LIVER; MICE; STREPTOZOCIN;

MUS;

EID: 36148965549     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1104     Document Type: Article

References (39)

1. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (Adipose Most abundant Gene transcript 1). Biochem Biophys Res Commun 1996; 221: 286-289.
2. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem (Tokyo) 1996; 120: 803-812.
3. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697-10703.
4. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746-26749.
5. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000; 106: 473-481.
6. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106: 171-176.
7. Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423: 762-769.
8. Yamauchi T, Kamon J, Waki H. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7: 941-946.
9. Shklyaev S, Aslanidi G, Tennant M, et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad Sci U S A 2003; 100: 14217-14222.
10. Satoh H, Nguyen MT, Trujillo M, et al. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes 2005; 54: 1304-1313.
11. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6: 1258-1266.
12. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737.
13. Jiang J, Yamato E. Miyazaki J. Long-term control of food intake and body weight by hydrodynamics-based delivery of plasmid DNA encoding leptin or CNTF. J Gene Med 2003; 5: 977-983.
14. He CX, Shi D, Wu WJ, et al. Insulin expression in livers of diabetic mice mediated by hydrodynamics-based administration. World J Gastroenterol 2004; 10: 567-572.
15. Park JH, Lee M, Kim SW. Non-viral adiponectin gene therapy into obese type 2 diabetic mice ameliorates insulin resistance. J Control Release 2006; 114: 118-125.
16. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8: 1288-1295.
17. Hattori Y, Maitani Y. Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase. Cancer Gene Ther 2005; 12: 796-809.
18. Kamata K, Sugiura M, Kojima S, Kasuya Y. Preservation of endothelium-dependent relaxation in cholesterol-fed and streptozotocin-induced diabetic mice by the chronic administration of cholestyramine. Br J Pharmacol 1996; 118: 385-391.
19. Takamatsu H, Kakiuchi T, Noda A, et al. An application of a new planar positron imaging system (PPIS) in a small animal: MPTP-induced parkinsonism in mouse. Ann Nucl Med 2004; 18: 427-431.
20. Uchida H, Okamoto T, Ohmura T, et al. A compact planar positron imaging system. Nucl Instrum Methods in Phys Res, Sect A 2004; 516: 564-574.
21. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83.
22. Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: 1930-1935.
23. Stefan N, Stumvoll M, Vozarova B, et al. Plasma adiponectin and endogenous glucose production in humans. Diabetes Care 2003; 26: 3315-3319.
24. Imagawa A, Funahashi T, Nakamura T, et al. Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes. Diabetes Care 2002; 25: 1665-1666.
25. Morales A, Wasserfall C, Brusko T, et al. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care 2004; 27: 2010-2014.
26. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001; 7: 947-953.
27. Inukai K, Nakashima Y, Watanabe M, et al. Regulation of adiponectin receptor gene expression in diabetic mice. Am J Physiol Endocrinol Metab 2005; 288: E876-E882.
28. Thule PM, Campbell AG, Kleinhenz DJ, et al. Hepatic insulin gene therapy prevents deterioration of vascular function and improves adipocytokine profile in STZ-diabetic rats. Am J Physiol Endocrinol Metab 2006; 290: E114-E122.
29. Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001; 108: 1875-1881.
30. Tsuchida A, Yamauchi T, Ito Y, et al. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 2004; 279: 30817-30822.
31. Tsuchida A, Yamauchi T, Kadowaki T. Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin. J Pharmacol Sci 2005; 97: 164-170.
32. Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 2001; 98: 2005-2010.
33. Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 1998; 67: 821-855.
34. Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999; 277: E1-E10.
35. Mu J, Brozinick JT Jr, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 2001; 7: 1085-1094.
36. Lochhead PA, Salt IP, Walker KS, Hardie DG, Sutherland C. 5-Aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes 2000; 49: 896-903.
37. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005; 26: 439-451.
38. Alino SF, Herrero MJ, Noguera I, Dasi F, Sanchez M. Pig liver gene therapy by noninvasive interventionist catheterism. Gene Ther 2007; 14: 334-343.
39. Tada M, Hatano E, Taura K, et al. High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. J Gene Med 2006; 8: 1018-1026.