Replication-Dependent Radiosensitization of Human Glioma Cells by Inhibition of Poly(ADP-Ribose) Polymerase: Mechanisms and Therapeutic Potential

International Journal of Radiation Oncology Biology Physics

Volumn 72, Issue 4, 2008, Pages 1188-1197

  Dungey, Fiona A ^a   Löser, Dana A ^a   Chalmers, Anthony J ^a,b  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Glioblastoma multiforme; KU 0059436; Poly(ADP ribose) polymerase; Radiosensitizer; Radiotherapy

Indexed keywords

ABS RESINS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURE; CELLS; CYTOLOGY; DNA; FUNCTIONAL POLYMERS; GENES; IONIZING RADIATION; MAGNESIUM PRINTING PLATES; NUCLEIC ACIDS; ORGANIC ACIDS; RADIOTHERAPY;

CLINICAL TRIALS; EVALUATING; FRACTIONATED RADIATIONS; GLIOBLASTOMA MULTIFORME; GLIOMA CELL LINES; GLIOMA CELLS; KU-0059436; NONTOXIC INHIBITORS; NORMAL TISSUES; PHASE I'VE; PHASE II; POLY(ADP-RIBOSE) POLYMERASE; RADIATION SENSITIVITIES; RADIOSENSITIZATION; RADIOSENSITIZER; REPLICATION FORKS; S-PHASE; SINGLE AGENTS; STRAND BREAKS;

ANIMAL CELL CULTURE;

APHIDICOLIN; AZD 2281; GLYCOSYLTRANSFERASE INHIBITOR; HISTONE H2AX; KU 0059436; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; RAD51 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL SYNCHRONIZATION; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIOSENSITIZATION;

APOPTOSIS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLIOMA; HUMANS; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; RADIATION DOSAGE; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION;

EID: 54049112348     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.07.031     Document Type: Article

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