GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin

Neuropharmacology

Volumn 55, Issue 7, 2008, Pages 1231-1237

  Wang, Feng ^a   Xu, Zhiwen ^a   Ren, Lihuan ^a   Tsang, Shui Ying ^a   Xue, Hong ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Amnesia; Anticonvulsant; Benzodiazepine; Flavonoids; Side effect

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BAICALIN; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; COMPLEMENTARY DNA; DIAZEPAM; FLAVONOID; FLUMAZENIL; FLUNITRAZEPAM; PICROTOXIN; RECEPTOR SUBTYPE; TRITIUM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; AVOIDANCE BEHAVIOR; BINDING AFFINITY; CELL STRAIN HEK293; CONVULSION; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; HUMAN; HUMAN CELL; INSTITUTE FOR CANCER RESEARCH MOUSE; LIGAND BINDING; MEMORY; MOTOR PERFORMANCE; NEUROBLASTOMA CELL; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; ROTAROD TEST; SEIZURE; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CELL LINE; CONVULSANTS; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGY; FLAVONOIDS; MALE; MICE; MICE, INBRED ICR; PATCH-CLAMP TECHNIQUES; PICROTOXIN; POSTURAL BALANCE; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; SEIZURES;

EID: 54049111741     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.07.040     Document Type: Article

References (32)

1. Akao T., Kawabata K., Yanagisawa E., Ishihara K., Mizuhara Y., Wakui Y., Skashita Y., and Kobashi K. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J. Pharm. Pharmacol. 52 (2000) 1563-1568
2. A receptors. Br. J. Pharmacol. 144 (2005) 357-366
3. A receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50 (1998) 291-313
4. Benson J.A., Low K., Keist R., Möhler H., and Rudolph U. Pharmacology of recombinant gamma-aminobutyric acid A receptors rendered diazepam-insensitive by point-mutated alpha-subunits. FEBS Lett. 431 (1998) 400-404
5. Braestrup C., Honore T., Nielsen M., Petersen E.N., and Jensen L.H. Ligands for benzodiazepine receptors with positive and negative efficacy. Biochem. Pharmacol. 33 (1984) 859-862
6. Crestani F., Low K., Keist R., Mandelli M., Möhler H., and Rudolph U. Molecular targets for the myorelaxant action of diazepam. Mol. Pharmacol. 59 (2001) 442-445
7. A receptors in mediating the anxiolytic effects of benzodiazepines. J. Neurosci. 25 (2005) 10682-10688
8. Gardner C.R., Tully W.R., and Hedgecock C.J. The rapidly expanding range of neuronal benzodiazepine receptor ligands. Prog. Neurobiol. 40 (1993) 1-61
9. Hadingham K.L., Wingrove P., Le Bourdelles B., Palmer K.J., Ragan C.I., and Whiting P.J. Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acid A receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. Mol. Pharmacol. 43 (1993) 970-975
10. Haefely W.E., Martin J.R., Richards J.G., and Schoch P. The multiplicity of actions of benzodiazepine receptor ligands. Can. J. Psychiatry 38 (1993) S102-S108
11. Hui K.M., Wang X.H., and Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med. 66 (2000) 91-93
12. Johnstone T.B., Hogenkamp D.J., Coyne L., Su J., Halliwell R.F., Tran M.B., Yoshimura R.F., Li W.Y., Wang J., and Gee K.W. Modifying quinolone antibiotics yields new anxiolytics. Nat. Med. 10 (2004) 31-32
13. A receptors. Prog. Neurobiol. 67 (2002) 113-159
14. A receptor subtypes: clinical efficacy and selectivity of benzodiazepine site ligands. Ann. Med. 29 (1997) 275-282
15. Lai M.Y., Hsiu S.L., Tsai S.Y., Hou Y.C., and Chao P.D. Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. J. Pharm. Pharmacol. 55 (2003) 205-209
16. Liao J.F., Hung W.Y., and Chen C.F. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Eur. J. Pharmacol. 464 (2003) 141-146
17. Low K., Crestani F., Keist T., Benke D., Brunig I., Benson J.A., Fritschy J.M., Rulicke T., Bluethmann H., Möhler H., and Rudolph U. Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290 (2000) 131-134
18. A receptor channels. Annu. Rev. Neurosci. 17 (1994) 569-602
19. A-receptor ligands of flavonoid structure. Curr. Top. Med. Chem. 2 (2002) 853-867
20. McKernan R.M., Rosahl T.W., Reynolds D.S., Sur C., Wafford K.A., Atack J.R., Farrar S., Myers J., Cook G., Ferris P., Garrett L., Bristow L., Marshall G., Macaulay A., Brown N., Howell O., Moore K.W., Carling R.W., Street L.J., Castro J.L., Ragan C.I., Dawson G.R., and Whiting P.J. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat. Neurosci. 3 (2000) 587-592
21. A-receptor subtypes really occur in the brain?. Trends. Neurosci. 19 (1996) 139-143
22. Möhler H., Fritschy J.M., and Rudolph U. A new benzodiazepine pharmacology. J. Pharmacol. Exp. Ther. 300 (2002) 2-8
23. A receptor research. Synapse 21 (1995) 189-274
24. Rudolph U., Crestani F., Benke D., Brunig I., Benson J.A., Fritschy J.M., Martin J.R., Bluethmann H., and Möhler H. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature 401 (1999) 796-800
25. Rudolph U., and Möhler H. GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr. Opin. Pharmacol. 6 (2006) 18-23
26. A receptor interactions: a comparison between cell lines and cerebellar Purkinje cells. J. Pharmacol. Exp. Ther. 284 (1998) 768-776
27. A receptor subtypes. Curr. Top. Med. Chem. 2 (2002) 795-816
28. A receptor complex. Curr. Drug Targets CNS Neurol. Disord. 4 (2005) 575-585
29. A receptor benzodiazepine site. Neuropharmacology 53 (2007) 574-582
30. Whiting P.J. GABA-A receptors: a viable target for novel anxiolytics?. Curr. Opin. Pharmacol. 6 (2006) 24-29
31. Xu Z., Wang F., Tsang S.Y., Ho K.H., Zheng H., Yuen C.T., Chow C.Y., and Xue H. Anxiolytic-like effect of baicalin and its additivity with other anxiolytics. Planta Med. 72 (2006) 189-192
32. Zhang L., Xing D., Wang W., Wang R., and Du L. Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract. J. Ethnopharmacol. 103 (2006) 120-125