Soluble endothelial protein C receptor levels in Behçet patients with and without ocular involvement

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 246, Issue 11, 2008, Pages 1603-1608

  Yalçindaǧ, F Nilüfer ^a,b   Batioǧlu, Figen ^a   Özdemir, Özden ^a   Cansizoǧlu, Esra ^a   Eǧin, Yonca ^a   Akar, Nejat ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Beh et's disease; Endothelial cell activated protein C receptor; Ocular involvement; Soluble endothelial cell activated protein C receptor

Indexed keywords

ENDOTHELIAL PROTEIN C RECEPTOR;

ADULT; AGE DETERMINATION; ARTHRITIS; ARTICLE; BEHCET DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE DISEASE; EYE EXAMINATION; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; GENITAL ULCER; HUMAN; MAJOR CLINICAL STUDY; MALE; MOUTH ULCER; NEUROLOGIC DISEASE; ORCHITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION; RETINA VASCULITIS; SEX DIFFERENCE; SKIN DEFECT; SUPERFICIAL THROMBOPHLEBITIS; UVEITIS;

ADULT; BEHCET SYNDROME; BLOOD COAGULATION FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE DISEASES; FEMALE; HUMANS; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; RECEPTORS, CELL SURFACE; SOLUBILITY; YOUNG ADULT;

EID: 54049105245     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-008-0873-9     Document Type: Article

References (49)

1. Akar N, Gokdemir R, Ozel D, Akar E (2002) Endothelial cell protein C receptor (EPCR) gene exon III, 23-bp insertion mutation in the Turkish pediatric thrombotic patients. Thromb Haemost 88:1068-1069
2. Ates A, Duzgun N, Ulu A, Tiryaki AO, Akar N (2003) Factor V gene (1691A and 4070G) and prothrombin gene 20210A mutations in patients with Behcet's disease. Pathophysiol Haemost Thromb 33:157-163 doi: 10.1159/ 000077824
3. Batioglu F, Atmaca LS, Karabulut HG, Sayin DB (2003) Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease. Acta Ophthalmol Scand 81:283-285 doi: 10.1034/j.1600-0420.2003.00068.x
4. Biguzzi E, Merati G, Liaw PC, Bucciarelli P, Oganesyan N, Qu D, Gu JM, Fetiveau R, Esmon CT, Mannucci PM, Faioni EM (2001) A 23-bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. Thromb Haemost 86:945-948
5. Boomsma MM, Stearns-Kurosawa DJ, Stegeman CA, Raschi E, Meroni PL, Kurosawa S, Tervaert JW (2002) Plasma levels of soluble endothelial cell protein C receptor in patients with Wegener's granulomatosis. Clin Exp Immunol 128:187-194 doi: 10.1046/j.1365-2249.2002.01803.x
6. Chambers JC, Haskar DO, Kooner JS (2001) Vascular endothelial function and oxidative stress mechanism in patients with Behçet's syndrome. J Am Coll Cardiol 37:517-520 doi: 10.1016/S0735-1097(00)01137-2
7. Conway EM, Rosenberg RD (1988) Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 8:5588-5592
8. Esmon CT, Gu J, Xu J, Qu D, Stearns-Kurosawa DJ, Kurosawa S (1999) Regulation and functions of the protein C anticoagulant pathway. Haematologica 84:363-368
9. Esmon CT (2003) The protein C pathway. Chest 124:26-32 doi: 10.1378/ chest.124.3_suppl.26S
10. Esmon CT (2004) Crosstalk between inflammation and thrombosis. Maturitas 47:305-314 doi: 10.1016/j.maturitas.2003.10.015
11. Esmon CT (2004) Structure and functions of the endothelial cell protein C receptor. Crit Care Med 32:298-301 doi: 10.1097/ 01.CCM.0000126128.64614.81
12. Esmon CT (2005) Coagulation inhibitors in inflammation. Biochem Soc Trans 33:401-405 doi: 10.1042/BST0330401
13. Espinosa G, Font J, Tassies D, Vidaller A, Deulofeu R, Lopez-Soto A, Cervera R, Ordinas A, Ingelmo M, Reverter J (2002) Vascular involvement in Behçet's disease: Relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med 112:37-43 doi: 10.1016/S0002-9343(01)01048-8
14. Faioni EM, Ferrero S, Fontana G, Gianelli U, Ciulla MM, Vecchi M, Saibeni S, Biguzzi E, Cordani N, Franchi F, Bosari S, Cattaneo M (2004) Expression of endothelial protein C receptor and thrombomodulin in the intestinal tissue of patients with inflammatory bowel disease. Crit Care Med 32:266-270 doi: 10.1097/01.CCM.0000128032.85396.83
15. Fukudome K, Esmon CT (1994) Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 269:26486-26491
16. Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR, Esmon CT (1996) The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem 271:17491-17498 doi: 10.1074/jbc.271.29.17491
17. Galligan L, Livingstone W, Volkov Y, Hokamp K, Murphy C, Lawler M, Fukudome K, Smith O (2001) Characterization of protein C receptor expression in monocytes. Br J Haematol 115:408-414 doi: 10.1046/ j.1365-2141.2001.03187.x
18. Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW (1994) Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ or phorbol ester. J Immunol 153:3664-3672
19. Gul A, Ozbek U, Ozturk C, Inanc M, Koniçe M, Ozçelik T (1996) Coagulation factor V gene mutation increases the risk of venous thrombosis in Behçet's disease. Br J Rheumatol 35:1178-1180 doi: 10.1093/rheumatology/35.11.1178
20. Gumus K, Kadayifcilar S, Eldem B, Saracbasi O, Ozcebe O, Dundar S, Kirazli S (2006) Is elevated level of soluble endothelial protein C receptor a new risk factor for retinal vein occlusion. Clin Experiment Ophthalmol 34:305-311 doi: 10.1111/j.1442-9071.2006.01212.x
21. Haznedaroglu IC, Ozcebe O, Çelik I, Dündar SV, Kirazli S (1996) Haemostatic markers of procoagulant imbalance in Behçet's disease. Eur J Haematol 57:107-108
22. Kiraz S, Ertenli I, Ozturk MA, Haznedaroglu IC, Celik I, Calguneri M (1994) Pathological haemostasis and 'prothrombotic state' in Behçet's disease. Thromb Res 105:125-133 doi: 10.1016/ S0049-3848(02)00006-3
23. Kosar A, Haznedaroglu IC, Buyukasik Y, Kirazli S, Dundar SV (1998) Activated protein C resistance in Behçet's disease. Rheumatol Int 17:249-250 doi: 10.1007/s002960050043
24. Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT (1997) Identification of functional endothelial protein C receptor in human plasma. J Clin Invest 100:411-418 doi: 10.1172/JCI119548
25. Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Della Valle P, Esmon CT (1998) Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood 91:725-727
26. Laszik Z, Mitro A, Taylor FB Jr, Ferrell G, Esmon CT (1997) Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway. Circulation 96:3633-3640
27. Lee YJ, Kang SW, Yang JI, Choi YM, Sheen D, Lee EB, Choi SW, Song YW (1994) Coagulation parameters and plasma total homocysteine levels in Behcet's disease. Thromb Res 106:19-24 doi: 10.1016/S0049-3848(02)00085-3
28. Liaw PCY, Neuenschwander PF, Smirnov MD, Esmon CT (2000) Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem 275:5447-5452 doi: 10.1074/ jbc.275.8.5447
29. Lie JT (1992) Vascular involvement in Behçet's disease: Arterial and venous and vessels of all sizes. J Rheumatol 19:341-343
30. Murakami K, Okajima K, Uchiba M, Johno M, Nakagaki T, Okabe H, Takatsuki K (1996) Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood 87:642-647
31. Murakami K, Okajima K, Uchiba M, Johno M, Nakagaki T, Okabe H, Takatsuki K (1997) Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol 272:197-202
32. Murphy C, Livingstone WJ, White B (2001) Activated protein C inhibits upregulation of both tissue factor and TNF-α in endotoxin stimulated monocytes. Thromb Haemost Suppl: 509
33. Oner AF, Gurgey A, Gurler A, Mesci L (1998) Factor V Leiden mutation in patients with Behçet's disease. J Rheumatol 25:496-498
34. Regan LM, Mollica JS, Rezaie AR, Esmon CT (1997) The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. J Biol Chem 272:26279-26284 doi: 10.1074/jbc.272.42.26279
35. Rizzi R, Bruno S, Dammacco R (1997) Behçet's disease: An immune-mediated vasculitis involving vessels of all sizes. Int J Clin Lab Res 27:225-232 doi: 10.1007/s005990050002
36. Sakane T, Takeno M, Suzuki N, Inaba G (1999) Behçet's disease. N Eng J Med 341:1284-1291 doi: 10.1056/NEJM199910213411707
37. Saposnik B, Reny JL, Gaussem P, Emmerich J, Aiach M, Gandrille S (2004) EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood 103:1311-1318 doi: 10.1182/ blood-2003-07-2520
38. Simioni P, Morboeuf O, Tognin G, Gavasso S, Tormene D, Woodhams B, Pagnan A (2006) Soluble endothelial cell protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants. Thromb Res 117:523-528 doi: 10.1016/ j.thromres.2005.04.029
39. Simmonds RE, Lane DA (2001) The endothelial cell protein C receptor: A candidate genetic risk factor for thrombosis. Thromb Haemost 86:939-941
40. Sipahi T, Pocan H, Akar N (2006) Effects of various genetic polymorphisms on the incidence and outcome of severe sepsis. Clin Appl Thrombosis/Hemostasis 12:47-54 doi: 10.1177/107602960601200108
41. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT (1996) The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 93:10212-10216 doi: 10.1073/pnas.93.19.10212
42. Stearns-Kurosawa DJ, Swindle K, D'Angelo A, Della Valle P, Fattorini A, Caron N, Grimaux M, Woodhams B, Kurosawa S (2002) Plasma levels of endothelial protein C receptor respond to anticoagulant treatment. Blood 99:526-530 doi: 10.1182/blood.V99.2.526
43. Sturn DH, Kaneider NC, Feistritzer C, Djanani A, Fukudome K, Wiedermann CJ (2003) Expression and function of the endothelial protein C receptor in human neutrophils. Blood 102:1499-1505 doi: 10.1182/blood-2002-12-3880
44. Taylor FB Jr, Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang AC, Laszik Z, Kosanke S, Peer G, Esmon CT (2000) The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 95:1680-1686
45. Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT (2001) Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 97:1685-1688 doi: 10.1182/blood.V97.6.1685
46. Toydemir PB, Elhan AH, Tükün A, Toydemir R, Gürler A, Tüzüner A, Bokesoy I (2000) Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothrombin gene G20210A mutations on deep venous thrombosis in Behçet's disease. J Rheumatol 27:2849-2854
47. Uitte D Willige S, Van Marion V, Rosendaal FR, Vos HL, De Visser MCH, Bertina RM (2004) Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis. J Thromb Haemost 2:1305-1310 doi: 10.1046/j.1538-7836.2004.00855.x
48. Ulu A, Gunal D, Tiras S, Egin Y, Deda G, Akar N (2007) EPCR gene A3 haplotype and elevated soluble endothelial protein C receptor (sEPCR) levels in Turkish pediatric stroke patients. Thromb Res 120:47-52 doi: 10.1016/j.thromres.2006.08.004
49. Verity DH, Vaughan RW, Madanat W, Kondeatis E, Zureikat H, Fayyad F, Kanawati CA, Ayesh I, Stanford MR, Wallace GR (1999) Factor V Leiden mutation is associated with ocular involvement in Behçet's disease. Am J Ophthalmol 128:352-356 doi: 10.1016/S0002-9394(99)00184-1