A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function

Thrombosis and Haemostasis

Volumn 86, Issue 4, 2001, Pages 945-948

  Biguzzi, E ^a   Merati, G ^a   Liaw, P C Y ^a   Bucciarelli, P ^a   Oganesyan, N ^a   Qu, D ^a   Gu, J M ^a   Fetiveau, R ^a   Esmon, C T ^a   Mannucci, P M ^a   Faioni, E M ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Deep vein thrombosis; Endothelial protein C receptor; Gene mutations; Myocardial infarction

Indexed keywords

ACTIVATED PROTEIN C; ENDOTHELIAL PROTEIN C RECEPTOR; MEMBRANE PROTEIN; PROTEIN C; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; DEEP VEIN THROMBOSIS; DISEASE PREDISPOSITION; GENE INSERTION; GENE MUTATION; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SURVIVAL;

EID: 0034774749     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616515     Document Type: Article

References (13)

1. Human protein C receptor is present primarily on endothelium of large vessels: Implications in the control of the protein C pathway
2. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
3. Endothelial cell protein C receptor plays an important role in protein C activation in vivo
4. Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function
5. Metalloproteolytic release of Endothelial Cell Protein C Receptor
6. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
7. The soluble endothelial protein C receptor binds to activated neutrophils: Involvement of proteinase-3 and CD11b/CD18
8. Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: Comparison with the structure of CD1/major histocompatibility complex α1 and α2 domains
9. International diagnostic criteria for acute myocardial infarction and acute stroke
10. The endothelial cell protein C receptor: Cell surface expression and direct ligand binding by the soluble receptor
11. Identification of functional endothelial protein C receptor in human plasma
12. Active site selective labeling of serine proteases with spectroscopic probes using thioester peptide chloromethyl ketones: Demonstration of thrombin labeling using N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl
13. Endothelial cell protein C receptor (EPCR) constituvely translocates into the nucleus and also mediates activated protein C, but not protein C, nuclear translocation