-
1
-
-
0025863475
-
-
Lancet. 338:1991;131-137.
-
(1991)
Lancet
, vol.338
, pp. 131-137
-
-
-
2
-
-
0027080461
-
Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation
-
Cziezel A RE, Dudas I. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med. 327:1992;183-1835.
-
(1992)
N Engl J Med
, vol.327
, pp. 183-1835
-
-
Cziezel, A.R.1
Dudas, I.2
-
3
-
-
0019476413
-
Double-blind randimised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects
-
Laurence K M, James N, Miller M, Tennant G B, Campbell H. Double-blind randimised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. BMJ. 282:1981;1509-1511.
-
(1981)
BMJ
, vol.282
, pp. 1509-1511
-
-
Laurence, K.M.1
James, N.2
Miller, M.3
Tennant, G.B.4
Campbell, H.5
-
4
-
-
0020539902
-
Further experience of vitamin supplementation for prevention of neural tube defect recurrences
-
Smithells R W, Nevin N C, Seller M J, Sheppard S, Harris R, Read A P, Fielding D W, Walker S, Schorah C J, Wild J. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet. 1:1983;1027-1031.
-
(1983)
Lancet
, vol.1
, pp. 1027-1031
-
-
Smithells, R.W.1
Nevin, N.C.2
Seller, M.J.3
Sheppard, S.4
Harris, R.5
Read, A.P.6
Fielding, D.W.7
Walker, S.8
Schorah, C.J.9
Wild, J.10
-
5
-
-
0026618808
-
A randomised trial of low dose folic acid to prevent neural tube defects
-
Kirke P N, Daly L E, Elwood J H. A randomised trial of low dose folic acid to prevent neural tube defects. Arch Dis Child. 67:1992;1442-1446.
-
(1992)
Arch Dis Child
, vol.67
, pp. 1442-1446
-
-
Kirke, P.N.1
Daly, L.E.2
Elwood, J.H.3
-
6
-
-
0027145847
-
Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects
-
Kirke P N, Molloy A M, Daly L E, Burke H, Weir D G, Scott J M. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Quart J med. 86:1993;703-708.
-
(1993)
Quart J Med
, vol.86
, pp. 703-708
-
-
Kirke, P.N.1
Molloy, A.M.2
Daly, L.E.3
Burke, H.4
Weir, D.G.5
Scott, J.M.6
-
8
-
-
0028803474
-
A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects
-
Whitehead A S, Gallagher P, Mills J L, Kirke P N, Burke H, Molloy A M, Weir D G, Shields D C, Scott J M. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. Quart J Med. 88:1995;763-766.
-
(1995)
Quart J Med
, vol.88
, pp. 763-766
-
-
Whitehead, A.S.1
Gallagher, P.2
Mills, J.L.3
Kirke, P.N.4
Burke, H.5
Molloy, A.M.6
Weir, D.G.7
Shields, D.C.8
Scott, J.M.9
-
9
-
-
0031969348
-
Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-deydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate-synthetase) in patients with neural tube defects
-
Hol F A, van der Put N M, Geurds M P, Heil S G, Trijbels F J, Hamel C, Mariman E C, Blom H J. Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-deydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate-synthetase) in patients with neural tube defects. Clin Genet. 53:1998;119-125.
-
(1998)
Clin Genet
, vol.53
, pp. 119-125
-
-
Hol, F.A.1
Van Der Put, N.M.2
Geurds, M.P.3
Heil, S.G.4
Trijbels, F.J.5
Hamel, C.6
Mariman, E.C.7
Blom, H.J.8
-
11
-
-
0028844492
-
Mutated methylenetetrahaydrofolate reductase as a risk factor for spina bifida
-
Van der Put N JM, Steegers-Theunissen R PM, Frosst P, Trijbels F JM, Eskes T KAB, Van der Heuvel L P, Mariman E CM, den Heur M, Roger R, Blom H J. Mutated methylenetetrahaydrofolate reductase as a risk factor for spina bifida. Lancet. 346:1995;1070.
-
(1995)
Lancet
, vol.346
, pp. 1070
-
-
Van Der Put, N.J.1
Steegers-Theunissen, R.P.2
Frosst, P.3
Trijbels, F.J.4
Eskes, T.K.5
Van Der Heuvel, L.P.6
Mariman, E.C.7
Den Heur, M.8
Roger, R.9
Blom, H.J.10
-
12
-
-
0032856882
-
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
-
Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel R, Rozen R. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab. 67:1999;317-323.
-
(1999)
Mol Genet Metab
, vol.67
, pp. 317-323
-
-
Wilson, A.1
Platt, R.2
Wu, Q.3
Leclerc, D.4
Christensen, B.5
Yang, H.6
Gravel, R.7
Rozen, R.8
-
13
-
-
0031769901
-
Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy
-
Lucock M D, Daskalakis I, Lumb C H, Schorah C J, Levene M I. Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy. Mol Genet Metab. 65:1998;18-30.
-
(1998)
Mol Genet Metab
, vol.65
, pp. 18-30
-
-
Lucock, M.D.1
Daskalakis, I.2
Lumb, C.H.3
Schorah, C.J.4
Levene, M.I.5
-
14
-
-
13144282730
-
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
-
Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, heng H H, Rommens J M, Scherer S W, Rosenblatt D S, Gravel R A. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci. 95:1998;3059-3064.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 3059-3064
-
-
Leclerc, D.1
Wilson, A.2
Dumas, R.3
Gafuik, C.4
Song, D.5
Watkins, D.6
Heng, H.H.7
Rommens, J.M.8
Scherer, S.W.9
Rosenblatt, D.S.10
Gravel, R.A.11
-
15
-
-
0029937753
-
Homocysteine and neural tube defects
-
Mills J L, Scott J M, Kirke P N, McPartlin J M, Conley M R, Weir D G, Molloy A M, Lee Y J. Homocysteine and neural tube defects. J Nutr. 126:1996;7565-7605.
-
(1996)
J Nutr
, vol.126
, pp. 7565-7605
-
-
Mills, J.L.1
Scott, J.M.2
Kirke, P.N.3
McPartlin, J.M.4
Conley, M.R.5
Weir, D.G.6
Molloy, A.M.7
Lee, Y.J.8
-
16
-
-
0001241628
-
5,10methylenetetrahydrofolate reductase C677T Genotypes and folate related risk factors for neural tube defects
-
W. Pfleiderer, & H. Rokos. Blackwell Science
-
Molloy A M, Ramsbottom D, McPartlin J, Whitehead A S, Weir D G, Scott J M. 5,10methylenetetrahydrofolate reductase C677T Genotypes and folate related risk factors for neural tube defects. Pfleiderer W, Rokos H. Chemistry and Biology of Pteridines 1997. 1997;291-296 Blackwell Science.
-
(1997)
Chemistry and Biology of Pteridines 1997
, pp. 291-296
-
-
Molloy, A.M.1
Ramsbottom, D.2
McPartlin, J.3
Whitehead, A.S.4
Weir, D.G.5
Scott, J.M.6
-
17
-
-
0029068197
-
Non-enzymatic degradation and salvage of dietary folate: Physicochemical factors likely to influence bioavailability
-
Lucock M D, Priestnall M, Daskalakis I, Schorah C J, Wild J, Levene M I. Non-enzymatic degradation and salvage of dietary folate: physicochemical factors likely to influence bioavailability. Biochem Molec Med. 55:1995;43-53.
-
(1995)
Biochem Molec Med
, vol.55
, pp. 43-53
-
-
Lucock, M.D.1
Priestnall, M.2
Daskalakis, I.3
Schorah, C.J.4
Wild, J.5
Levene, M.I.6
-
18
-
-
0022412895
-
Channeling between the active sites of formiminotransferase-cyclodeaminase
-
Paquin J, Baugh C M, MacKenzie R E. Channeling between the active sites of formiminotransferase-cyclodeaminase. J Biol Chem. 260:1985;14925-14931.
-
(1985)
J Biol Chem.
, vol.260
, pp. 14925-14931
-
-
Paquin, J.1
Baugh, C.M.2
MacKenzie, R.E.3
-
19
-
-
0032790492
-
Folate-homocysteine interrelations: Potential new markers of folate status
-
Lucock M D, Daskalakis I, Schorah C J, Lumb C H, Oliver M, Devitt H, Wild J, Dowell A C, Levene M I. Folate-homocysteine interrelations: Potential new markers of folate status. Mol Genet Metab. 67:1999;23-35.
-
(1999)
Mol Genet Metab
, vol.67
, pp. 23-35
-
-
Lucock, M.D.1
Daskalakis, I.2
Schorah, C.J.3
Lumb, C.H.4
Oliver, M.5
Devitt, H.6
Wild, J.7
Dowell, A.C.8
Levene, M.I.9
-
20
-
-
0029813018
-
Determination of plasma total homocysteine and cysteine using hplc and fluorescence detection and an SBDF derivatisation protocol optimised for antioxidant concentration, derivatisation reagent concentration, temperature and matrix pH
-
Daskalakis I, Lucock M D, Anderson A, Wild J, Schorah C J, Levene M I. Determination of plasma total homocysteine and cysteine using hplc and fluorescence detection and an SBDF derivatisation protocol optimised for antioxidant concentration, derivatisation reagent concentration, temperature and matrix pH. Biomed Chromatogr. 10:1995;205-212.
-
(1995)
Biomed Chromatogr
, vol.10
, pp. 205-212
-
-
Daskalakis, I.1
Lucock, M.D.2
Anderson, A.3
Wild, J.4
Schorah, C.J.5
Levene, M.I.6
-
21
-
-
0029049553
-
A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
-
Frosst P, Blom H J, Milos R, Goyette P, Sheppard C A, Matthews R G, Boers G J, den Heijer M, Kluijtmans L A, Van den Heuvel L P. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nature Genet. 10:1995;111-113.
-
(1995)
Nature Genet
, vol.10
, pp. 111-113
-
-
Frosst, P.1
Blom, H.J.2
Milos, R.3
Goyette, P.4
Sheppard, C.A.5
Matthews, R.G.6
Boers, G.J.7
Den Heijer, M.8
Kluijtmans, L.A.9
Van Den Heuvel, L.P.10
-
22
-
-
0030804226
-
Sequence analysis of the coding region of human methionine synthase: Relevance to hyperhomocysteinaemia in NTD and vascular disease
-
Van der Put N JM, Van der Molen E F, Kluijtmans L AJ, Heil S G, Trijbels J MF, Eskes T KAB, Oppenraaij-Emmerzaal D V, Banerjee R, Blom H J. Sequence analysis of the coding region of human methionine synthase: Relevance to hyperhomocysteinaemia in NTD and vascular disease. Quart J Med. 90:1997;511-517.
-
(1997)
Quart J Med
, vol.90
, pp. 511-517
-
-
Van Der Put, N.J.1
Van Der Molen, E.F.2
Kluijtmans, L.A.3
Heil, S.G.4
Trijbels, J.M.5
Eskes, T.K.6
Oppenraaij-Emmerzaal, D.V.7
Banerjee, R.8
Blom, H.J.9
-
23
-
-
0023072389
-
Folyl polyglutamates as substrates and inhibitors of folate-dependent enzymes
-
Matthews R G, Ghose C, Green J M, Matthews K D, Dunlap R B. Folyl polyglutamates as substrates and inhibitors of folate-dependent enzymes. Adv Enzyme Reg. 26:1987;157-1171.
-
(1987)
Adv Enzyme Reg
, vol.26
, pp. 157-1171
-
-
Matthews, R.G.1
Ghose, C.2
Green, J.M.3
Matthews, K.D.4
Dunlap, R.B.5
-
24
-
-
0023815995
-
Substrate flux through methylenetetrahydrofolate dehydrogenase: Predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration
-
Green J M, Mackenzie R E, Matthews R G. Substrate flux through methylenetetrahydrofolate dehydrogenase: Predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration. Biochemistry. 27:1988;8014-8022.
-
(1988)
Biochemistry
, vol.27
, pp. 8014-8022
-
-
Green, J.M.1
MacKenzie, R.E.2
Matthews, R.G.3
-
25
-
-
4143088796
-
Spina bifida, 677ct mutation and role of folate
-
De franchis R, Seastio G, mandato C, Andria G, Mastroiacovo P. Spina bifida, 677ct mutation and role of folate. Lancet. 346:1995;1703.
-
(1995)
Lancet
, vol.346
, pp. 1703
-
-
De Franchis, R.1
Seastio, G.2
Mandato, C.3
Andria, G.4
Mastroiacovo, P.5
-
26
-
-
0029886679
-
Methylenetetrahydrofolate reductase and neural tube defects
-
Papapetrou C, Lynch S A, Burn J, Edwards Y H. Methylenetetrahydrofolate reductase and neural tube defects. Lancet. 348:1996;58.
-
(1996)
Lancet
, vol.348
, pp. 58
-
-
Papapetrou, C.1
Lynch, S.A.2
Burn, J.3
Edwards, Y.H.4
-
27
-
-
0023097820
-
Mammalian folyl-γ-glutmate synthetase: Substrate specificity and kinetic properties
-
Cichowitz D J, Shane B. Mammalian folyl-γ-glutmate synthetase: Substrate specificity and kinetic properties. Biochemistry. 26:1987;513-521.
-
(1987)
Biochemistry
, vol.26
, pp. 513-521
-
-
Cichowitz, D.J.1
Shane, B.2
-
28
-
-
0023129467
-
Mammalian folyl-γ-glutamate synthetase, 4: In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis
-
Cook J D, Cichowitz D J, George S, Lawler A, Shane B. Mammalian folyl-γ-glutamate synthetase, 4: In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis. Biochemistry. 26:1987;530-539.
-
(1987)
Biochemistry
, vol.26
, pp. 530-539
-
-
Cook, J.D.1
Cichowitz, D.J.2
George, S.3
Lawler, A.4
Shane, B.5
-
29
-
-
0015228022
-
Mammalian methylenetetrahydrofolate reductase: Partial purification, properties, and inhibition y S-adenosylmethionine
-
Kutzbach C, Stokstad E LR. Mammalian methylenetetrahydrofolate reductase: Partial purification, properties, and inhibition y S-adenosylmethionine. Biochim Biophys Acta. 250:1971;459-477.
-
(1971)
Biochim Biophys Acta
, vol.250
, pp. 459-477
-
-
Kutzbach, C.1
Stokstad, E.L.2
-
30
-
-
0021867328
-
Inhibition of glycine N-methyltransferase by folate derivatives: Implications for regulation of methyl group metabolism
-
Wagner C, Briggs W T, Cook R J. Inhibition of glycine N-methyltransferase by folate derivatives: Implications for regulation of methyl group metabolism. Biochem Biophys Res Commun. 127:1985;746-752.
-
(1985)
Biochem Biophys Res Commun
, vol.127
, pp. 746-752
-
-
Wagner, C.1
Briggs, W.T.2
Cook, R.J.3
-
31
-
-
0020484785
-
Interactions of pig liver serine hydroxymethyltransferase with methyltetrahydropteroyl polyglutamate inhibitors and with tetrahydropteroylpolyglutamate substrates
-
Matthews R G, Ross J, Baugh C M, Cook J D, Dvis L. Interactions of pig liver serine hydroxymethyltransferase with methyltetrahydropteroyl polyglutamate inhibitors and with tetrahydropteroylpolyglutamate substrates. Biochemistry. 21:1982;1230-1238.
-
(1982)
Biochemistry
, vol.21
, pp. 1230-1238
-
-
Matthews, R.G.1
Ross, J.2
Baugh, C.M.3
Cook, J.D.4
Dvis, L.5
-
32
-
-
0024430290
-
Biotransformation of pteroylmonoglutamic acid during absorption: Implications of Michaelis-Menten kinetics
-
Lucock M, Wild J, Smithells R, Hartley R. Biotransformation of pteroylmonoglutamic acid during absorption: Implications of Michaelis-Menten kinetics. Eur J Clin Nutr. 43:1989;631-635.
-
(1989)
Eur J Clin Nutr
, vol.43
, pp. 631-635
-
-
Lucock, M.1
Wild, J.2
Smithells, R.3
Hartley, R.4
-
33
-
-
0024448203
-
Invivo characterisation of the absorption and biotransformation of pteroylglutamic acid in man: A model for future studies
-
Lucock M D, Wild J, Smithells R, Hartley R. Invivo characterisation of the absorption and biotransformation of pteroylglutamic acid in man: A model for future studies. Biochem Med Metab iol. 42:1989;30-42.
-
(1989)
Biochem Med Metab Iol
, vol.42
, pp. 30-42
-
-
Lucock, M.D.1
Wild, J.2
Smithells, R.3
Hartley, R.4
-
34
-
-
0001226131
-
Folate and the prevention of disease
-
W. Pfleiderer, & H. Rokos. Blackwell Science
-
Scott J M. Folate and the prevention of disease. Pfleiderer W, Rokos H. Chemistry and Biology of Pteridines 1997. 1997;277-290 Blackwell Science.
-
(1997)
Chemistry and Biology of Pteridines 1997
, pp. 277-290
-
-
Scott, J.M.1
-
35
-
-
0031597388
-
Folate, vitamin B12 and serum total homocysteine levels in confirmed alzheimers disease
-
Clarke R. Folate, vitamin B12 and serum total homocysteine levels in confirmed alzheimers disease. Arch Neurol. 55:1998;1449-1455.
-
(1998)
Arch Neurol
, vol.55
, pp. 1449-1455
-
-
Clarke, R.1
-
36
-
-
0019323528
-
Interactions of pig liver methylene tetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors
-
Matthews R G, Baugh C M. Interactions of pig liver methylene tetrahydrofolate reductase with methylenetetrahydropteroylpolyglutamate substrates and with dihydropteroylpolyglutamate inhibitors. Biochemistry. 19:1980;2040-2045.
-
(1980)
Biochemistry
, vol.19
, pp. 2040-2045
-
-
Matthews, R.G.1
Baugh, C.M.2
-
37
-
-
0027513805
-
The metabolic role of leucovorin
-
Stover P, Schirch V. The metabolic role of leucovorin. TIBS. 18:1993;102-106.
-
(1993)
TIBS
, vol.18
, pp. 102-106
-
-
Stover, P.1
Schirch, V.2
-
38
-
-
0025228772
-
Cobalamin-dependent methionine synthase
-
Banerjee, R, V, Matthews, R, G, Cobalamin-dependent methionine synthase, FASEB J4:1450-1459, 1990.
-
(1990)
FASEB J
, vol.4
, pp. 1450-1459
-
-
Banerjee, R.V.1
Matthews, R.G.2
|