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Unfortunately, under the same conditions, Grignard reagents (MeMgBr, MeMgI) did not react with imine 11. Phenylmagnesium bromide gradually reacted at -10°C in ther and toluene, but 20 was produced in low conversion (21-37%) and poor selectivity (ca. 56.0:44.0 er). [46] TMSCl, TBSCl, and TIPSCl (1.0 equiv.) were tested.
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Coordination of the imine to complex 12ac·MeLi can be achieved with MNDO if the optimization procedure is stopped at a gradient norm of 3
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Coordination of the imine to complex 12ac·MeLi can be achieved with MNDO if the optimization procedure is stopped at a gradient norm of 3. However, this geometry exhibits one imaginary frequency.
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However, this geometry exhibits one imaginary frequency
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